PMID- 32359
OWN - NLM
STAT- MEDLINE
DCOM- 19790313
LR  - 20190710
IS  - 0022-3573 (Print)
IS  - 0022-3573 (Linking)
VI  - 31
IP  - 1
DP  - 1979 Jan
TI  - A comparison of the cardiovascular effects of centrally administered clonidine 
      and adrenaline in the anaesthetized rat.
PG  - 16-9
AB  - Intracerebroventricular (i.c.v.) injections of clonidine and adrenaline-induced 
      hypotension and bradycardia in urethane anaesthetized spontaneous hypertensive 
      rats. The hypotension induced by clonidine (3 microgram i.c.v.) was antagonized 
      by pretreatment with the alpha-antagonists piperoxan, which also antagonized 
      clonidine-induced bradycardia, and yohimbine. The hypotension and bradycardia 
      induced by adrenaline (10 microgram i.c.v.) were unaffected by alpha-antagonist 
      pretreatment, while beta-antagonist pretreatment with (--)-propranolol or 
      metoprolol was effective against adrenaline but not clonidine-induced hypotension 
      and bradycardia. Pretreatments with the histamine H2-receptor antagonists 
      metiamide and cimetidine antagonized clonidine but not adrenaline-induced 
      hypotension. These data indicate that different central mechanisms are involved 
      in mediating the hypotension and bradycardia induced by centrally administered 
      clonidine and adrenaline and do not, therefore, support the hypothesis that the 
      hypotensive effects of clonidine (i.c.v.) are mediated by central adrenaline 
      receptor activation in urethane-anaesthetized spontaneous hypertensive rats.
FAU - Borkowski, K R
AU  - Borkowski KR
FAU - Finch, L
AU  - Finch L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - J Pharm Pharmacol
JT  - The Journal of pharmacy and pharmacology
JID - 0376363
RN  - MN3L5RMN02 (Clonidine)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Anesthesia
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Clonidine/administration & dosage/*pharmacology
MH  - Epinephrine/administration & dosage/*pharmacology
MH  - Heart Rate/drug effects
MH  - Hemodynamics/*drug effects
MH  - Injections, Intraventricular
MH  - Male
MH  - Rats
MH  - Time Factors
EDAT- 1979/01/01 00:00
MHDA- 1979/01/01 00:01
CRDT- 1979/01/01 00:00
PHST- 1979/01/01 00:00 [pubmed]
PHST- 1979/01/01 00:01 [medline]
PHST- 1979/01/01 00:00 [entrez]
AID - 10.1111/j.2042-7158.1979.tb13413.x [doi]
PST - ppublish
SO  - J Pharm Pharmacol. 1979 Jan;31(1):16-9. doi: 10.1111/j.2042-7158.1979.tb13413.x.