PMID- 32359340
OWN - NLM
STAT- MEDLINE
DCOM- 20210318
LR  - 20210318
IS  - 1875-6417 (Electronic)
IS  - 1573-3998 (Linking)
VI  - 17
IP  - 2
DP  - 2021
TI  - MicroRNA 21 Emerging Role in Diabetic Complications: A Critical Update.
PG  - 122-135
LID - 10.2174/1573399816666200503035035 [doi]
AB  - BACKGROUND: Diabetes Mellitus is a multifactorial disease encompassing various 
      pathogenic pathways. To avoid morbidity and mortality related to diabetic 
      complications, early detection of disease complications as well as targeted 
      therapeutic strategies are essential. INTRODUCTION: MicroRNAs (miRs) are short 
      non-coding RNA molecules that regulate eukaryotic posttranscriptional gene 
      expression. MicroRNA-21 has diverse gene regulatory functions and plays a 
      significant role in various complications of Type 2 diabetes mellitus (T2DM). 
      METHODS: The study included electronic database searches on Pubmed, Embase, and 
      Web of Science with the search items MicroRNA21 and each of the diabetic 
      complications. The search was carried out up to November, 2019. RESULTS: 
      MicroRNA-21 modulates diabetic cardiomyopathy by affecting vascular smooth muscle 
      cell proliferation and apoptosis, cardiac cell growth and death, and cardiac 
      fibroblast functions. At the renal tubules, miR-21 can regulate the mesangial 
      expansion, interstitial fibrosis, macrophage infiltration, podocyte loss, 
      albuminuria and fibrotic and inflammatory gene expression related to diabetic 
      nephropathy. Overexpression of miR-21 has been seen to play a pivotal role in the 
      pathogenesis of diabetic retinopathy by contributing to diabetes-induced 
      endothelial dysfunction as well as low-grade inflammation. CONCLUSION: 
      Considering the raised levels of miR-21 in various diabetic complications, it may 
      prove to be a candidate biomarker for diabetic complications. Further, miR-21 
      antagonists have shown great potential in the treatment of diabetic 
      cardiomyopathy, diabetic nephropathy, diabetic retinopathy, and diabetic 
      neuropathy related complications in the future. The current review is the first 
      of its kind encompassing the roles miR-21 plays in various diabetic 
      complications, with a critical discussion of its future potential role as a 
      biomarker and therapeutic target.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Roy, Dipayan
AU  - Roy D
AD  - Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), 
      Jodhpur, India.
FAU - Modi, Anupama
AU  - Modi A
AD  - Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), 
      Jodhpur, India.
FAU - Khokhar, Manoj
AU  - Khokhar M
AD  - Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), 
      Jodhpur, India.
FAU - Sankanagoudar, Shrimanjunath
AU  - Sankanagoudar S
AD  - Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), 
      Jodhpur, India.
FAU - Yadav, Dharamveer
AU  - Yadav D
AD  - Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), 
      Jodhpur, India.
FAU - Sharma, Shailja
AU  - Sharma S
AD  - Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), 
      Jodhpur, India.
FAU - Purohit, Purvi
AU  - Purohit P
AD  - Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), 
      Jodhpur, India.
FAU - Sharma, Praveen
AU  - Sharma P
AD  - Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), 
      Jodhpur, India.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Diabetes Rev
JT  - Current diabetes reviews
JID - 101253260
RN  - 0 (MIRN21 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Albuminuria
MH  - *Diabetes Mellitus, Type 2/complications/genetics
MH  - *Diabetic Nephropathies/genetics
MH  - *Diabetic Retinopathy/genetics
MH  - Humans
MH  - *MicroRNAs/genetics
OTO - NOTNLM
OT  - MicroRNA-21
OT  - Type 2 diabetes mellitus
OT  - diabetic neuropathy
OT  - diabetic cardiomyopathy
OT  - diabetic nephropathy
OT  - diabetic retinopathy
EDAT- 2020/05/04 06:00
MHDA- 2021/03/19 06:00
CRDT- 2020/05/04 06:00
PHST- 2019/12/25 00:00 [received]
PHST- 2020/03/13 00:00 [revised]
PHST- 2020/04/13 00:00 [accepted]
PHST- 2020/05/04 06:00 [pubmed]
PHST- 2021/03/19 06:00 [medline]
PHST- 2020/05/04 06:00 [entrez]
AID - CDR-EPUB-106300 [pii]
AID - 10.2174/1573399816666200503035035 [doi]
PST - ppublish
SO  - Curr Diabetes Rev. 2021;17(2):122-135. doi: 10.2174/1573399816666200503035035.