PMID- 32359431 OWN - NLM STAT- MEDLINE DCOM- 20210810 LR - 20221207 IS - 1879-0445 (Electronic) IS - 0960-9822 (Linking) VI - 30 IP - 11 DP - 2020 Jun 8 TI - Origin and Health Status of First-Generation Africans from Early Colonial Mexico. PG - 2078-2091.e11 LID - S0960-9822(20)30482-6 [pii] LID - 10.1016/j.cub.2020.04.002 [doi] AB - The forced relocation of several thousand Africans during Mexico's historic period has so far been documented mostly through archival sources, which provide only sparse detail on their origins and lived experience. Here, we employ a bioarchaeological approach to explore the life history of three 16(th) century Africans from a mass burial at the San Jose de los Naturales Royal Hospital in Mexico City. Our approach draws together ancient genomic data, osteological analysis, strontium isotope data from tooth enamel, delta(13)C and delta(15)N isotope data from dentine, and ethnohistorical information to reveal unprecedented detail on their origins and health. Analyses of skeletal features, radiogenic isotopes, and genetic data from uniparental, genome-wide, and human leukocyte antigen (HLA) markers are consistent with a Sub-Saharan African origin for all three individuals. Complete genomes of Treponema pallidum sub. pertenue (causative agent of yaws) and hepatitis B virus (HBV) recovered from these individuals provide insight into their health as related to infectious disease. Phylogenetic analysis of both pathogens reveals their close relationship to strains circulating in current West African populations, lending support to their origins in this region. The further relationship between the treponemal genome retrieved and a treponemal genome previously typed in an individual from Colonial Mexico highlights the role of the transatlantic slave trade in the introduction and dissemination of pathogens into the New World. Putting together all lines of evidence, we were able to create a biological portrait of three individuals whose life stories have long been silenced by disreputable historical events. CI - Copyright (c) 2020 Elsevier Inc. All rights reserved. FAU - Barquera, Rodrigo AU - Barquera R AD - Department of Archaeogenetics (DAG), Max-Planck Institute for the Science of Human History (MPI-SHH), Kahlaische Str. 10, 07745 Jena, Germany; Molecular Genetics Laboratory, Escuela Nacional de Antropologia e Historia (ENAH), Periferico Sur y Zapote s/n. Col. Isidro Fabela, Tlalpan, 14030 Mexico City, Mexico. FAU - Lamnidis, Thiseas C AU - Lamnidis TC AD - Department of Archaeogenetics (DAG), Max-Planck Institute for the Science of Human History (MPI-SHH), Kahlaische Str. 10, 07745 Jena, Germany. FAU - Lankapalli, Aditya Kumar AU - Lankapalli AK AD - Department of Archaeogenetics (DAG), Max-Planck Institute for the Science of Human History (MPI-SHH), Kahlaische Str. 10, 07745 Jena, Germany. FAU - Kocher, Arthur AU - Kocher A AD - Transmission, Infection, Diversification & Evolution Group (TIDE), Max-Planck Institute for the Science of Human History (MPI-SHH), Kahlaische Str. 10, 07745 Jena, Germany. FAU - Hernandez-Zaragoza, Diana I AU - Hernandez-Zaragoza DI AD - Molecular Genetics Laboratory, Escuela Nacional de Antropologia e Historia (ENAH), Periferico Sur y Zapote s/n. Col. Isidro Fabela, Tlalpan, 14030 Mexico City, Mexico; Immunogenetics Unit, Tecnicas Geneticas Aplicadas a la Clinica (TGAC), Calz. del Hueso 714, Coapa, Los Sauces, Coyoacan, 04940 Mexico City, CDMX, Mexico. FAU - Nelson, Elizabeth A AU - Nelson EA AD - Department of Archaeogenetics (DAG), Max-Planck Institute for the Science of Human History (MPI-SHH), Kahlaische Str. 10, 07745 Jena, Germany; Institute for the Archaeological Sciences, University of Tubingen, Geschwister-Scholl-Platz, 72074 Tubingen, Germany. FAU - Zamora-Herrera, Adriana C AU - Zamora-Herrera AC AD - Osteology Laboratory, Post Graduate Studies Division, Escuela Nacional de Antropologia e Historia (ENAH), Periferico Sur y Zapote s/n. Col. Isidro Fabela, Tlalpan, 14030 Mexico City, Mexico. FAU - Ramallo, Patxi AU - Ramallo P AD - Department of Archaeology (DA), Max-Planck Institute for the Science of Human History (MPI-SHH), Kahlaische Str. 10, 07745 Jena, Germany; Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Arriola Pasealekua, 2, 20018 Donostia, Gipuzkoa, Spain. FAU - Bernal-Felipe, Natalia AU - Bernal-Felipe N AD - Escuela Nacional de Antropologia e Historia (ENAH), Periferico Sur y Zapote s/n. Col. Isidro Fabela, Tlalpan, 14030 Mexico City, Mexico. FAU - Immel, Alexander AU - Immel A AD - Department of Archaeogenetics (DAG), Max-Planck Institute for the Science of Human History (MPI-SHH), Kahlaische Str. 10, 07745 Jena, Germany; Institute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105 Kiel, Germany. FAU - Bos, Kirsten AU - Bos K AD - Department of Archaeogenetics (DAG), Max-Planck Institute for the Science of Human History (MPI-SHH), Kahlaische Str. 10, 07745 Jena, Germany. FAU - Acuna-Alonzo, Victor AU - Acuna-Alonzo V AD - Molecular Genetics Laboratory, Escuela Nacional de Antropologia e Historia (ENAH), Periferico Sur y Zapote s/n. Col. Isidro Fabela, Tlalpan, 14030 Mexico City, Mexico. FAU - Barbieri, Chiara AU - Barbieri C AD - Department of Linguistic and Cultural Evolution (DLCE), Max-Planck Institute for the Science of Human History (MPI-SHH), Kahlaische Str. 10, 07745 Jena, Germany; Department of Evolutionary Biology and Environmental Studies, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. FAU - Roberts, Patrick AU - Roberts P AD - Department of Archaeology (DA), Max-Planck Institute for the Science of Human History (MPI-SHH), Kahlaische Str. 10, 07745 Jena, Germany. FAU - Herbig, Alexander AU - Herbig A AD - Department of Archaeogenetics (DAG), Max-Planck Institute for the Science of Human History (MPI-SHH), Kahlaische Str. 10, 07745 Jena, Germany. FAU - Kuhnert, Denise AU - Kuhnert D AD - Transmission, Infection, Diversification & Evolution Group (TIDE), Max-Planck Institute for the Science of Human History (MPI-SHH), Kahlaische Str. 10, 07745 Jena, Germany. Electronic address: kuehnert@shh.mpg.de. FAU - Marquez-Morfin, Lourdes AU - Marquez-Morfin L AD - Osteology Laboratory, Post Graduate Studies Division, Escuela Nacional de Antropologia e Historia (ENAH), Periferico Sur y Zapote s/n. Col. Isidro Fabela, Tlalpan, 14030 Mexico City, Mexico. Electronic address: rlmorfin@gmail.com. FAU - Krause, Johannes AU - Krause J AD - Department of Archaeogenetics (DAG), Max-Planck Institute for the Science of Human History (MPI-SHH), Kahlaische Str. 10, 07745 Jena, Germany. Electronic address: krause@shh.mpg.de. LA - eng PT - Historical Article PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200430 PL - England TA - Curr Biol JT - Current biology : CB JID - 9107782 RN - 0 (DNA, Ancient) RN - Treponema pallidum subsp. pertenue SB - IM MH - Adult MH - Archaeology MH - Black People/history MH - DNA, Ancient/*analysis MH - Enslaved Persons/*history MH - *Health Status MH - Hepatitis B/*history MH - Hepatitis B virus/isolation & purification MH - History, 16th Century MH - Humans MH - Male MH - Mexico MH - Treponema/isolation & purification MH - Yaws/*history MH - Young Adult OTO - NOTNLM OT - African ancestry OT - New Spain OT - Treponema pallidum OT - ancient DNA OT - hepatitis B virus OT - transatlantic slave trade COIS- Declaration of Interests The authors declare no competing interests. EDAT- 2020/05/04 06:00 MHDA- 2021/08/11 06:00 CRDT- 2020/05/04 06:00 PHST- 2020/01/17 00:00 [received] PHST- 2020/03/03 00:00 [revised] PHST- 2020/04/01 00:00 [accepted] PHST- 2020/05/04 06:00 [pubmed] PHST- 2021/08/11 06:00 [medline] PHST- 2020/05/04 06:00 [entrez] AID - S0960-9822(20)30482-6 [pii] AID - 10.1016/j.cub.2020.04.002 [doi] PST - ppublish SO - Curr Biol. 2020 Jun 8;30(11):2078-2091.e11. doi: 10.1016/j.cub.2020.04.002. Epub 2020 Apr 30.