PMID- 32359533
OWN - NLM
STAT- MEDLINE
DCOM- 20200713
LR  - 20221207
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Print)
IS  - 0002-9629 (Linking)
VI  - 359
IP  - 5
DP  - 2020 May
TI  - Five-Year Glycemic Trajectories Among Healthy African-American and 
      European-American Offspring of Parents With Type 2 Diabetes.
PG  - 266-270
LID - S0002-9629(20)30078-1 [pii]
LID - 10.1016/j.amjms.2020.03.005 [doi]
AB  - BACKGROUND: Cross-sectional surveys report a higher prevalence of diagnosed type 
      2 diabetes mellitus (T2DM) in African Americans (AA) than European Americans 
      (EA). We studied 5-year glycemic excursions among AA and EA in the Pathobiology 
      of Prediabetes in A Biracial Cohort study, to assess ethnic disparities. 
      MATERIALS AND METHODS: Pathobiology of Prediabetes in A Biracial Cohort followed 
      normoglycemic offspring of parents with T2DM for 5 years, with serial assessments 
      of oral glucose tolerance test , anthropometry, body fat, insulin sensitivity and 
      beta-cell function. The primary outcome was progression to prediabetes (impaired 
      fasting glucose and/or impaired glucose tolerance). We further analyzed 5-year 
      changes in fasting (FPG) and 2-hour plasma glucose (2hrPG). RESULTS: One hundred 
      and one (52 AA, 49 EA) out of 343 subjects developed prediabetes during 
      follow-up. The change in FPG ranged from -24 mg/dl to +38 mg/dl. The FPG remained 
      stable (+/- 5 mg/dl from baseline) in 50% of EA and 46.8% of AA and the 2hrPG 
      remained stable (+/- 25 mg/dl from baseline) in 73.7% of EA and 71.0 % of AA during 
      follow-up. The proportions with change in FPG of 5mg/dl to >25 mg/dl and 2hrPG of 
      25 mg/dl to >50 mg/dl were similar in EA and AA offspring, as were the 10th - 
      90th percentiles of the distribution of 5-year changes in FPG and 2hrPG. 
      CONCLUSIONS: During 5 years of follow-up, black and white offspring of parents 
      with T2DM exhibited remarkable phenotypic concordance of glycemic trajectories. 
      Thus, parental history of T2DM may be a stronger factor than race/ethnicity in 
      the prediction of longitudinal glycemic trends.
CI  - Copyright (c) 2020 Southern Society for Clinical Investigation. Published by 
      Elsevier Inc. All rights reserved.
FAU - Razavi, Laleh N
AU  - Razavi LN
AD  - Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, 
      University of Tennessee Health Science Center, Memphis, Tennessee; Division of 
      Endocrinology, Case Western Reserve University, Cleveland, Ohio.
FAU - Ebenibo, Sotonte
AU  - Ebenibo S
AD  - Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, 
      University of Tennessee Health Science Center, Memphis, Tennessee.
FAU - Edeoga, Chimaroke
AU  - Edeoga C
AD  - Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, 
      University of Tennessee Health Science Center, Memphis, Tennessee.
FAU - Wan, Jim
AU  - Wan J
AD  - Department of Preventive Medicine, University of Tennessee Health Science Center, 
      Memphis, Tennessee.
FAU - Dagogo-Jack, Samuel
AU  - Dagogo-Jack S
AD  - Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, 
      University of Tennessee Health Science Center, Memphis, Tennessee; General 
      Clinical Research Center, University of Tennessee Health Science Center, Memphis, 
      Tennessee. Electronic address: sdj@uthsc.edu.
LA  - eng
GR  - R01 DK067269/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200309
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Black or African American
MH  - Anthropometry
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/blood/*ethnology
MH  - Family Health
MH  - Female
MH  - Follow-Up Studies
MH  - Glucose Intolerance/diagnosis
MH  - Glucose Tolerance Test
MH  - Glycated Hemoglobin/analysis
MH  - Healthcare Disparities
MH  - Humans
MH  - Hyperglycemia/blood
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Insulin-Secreting Cells/cytology
MH  - Male
MH  - Middle Aged
MH  - Parents
MH  - Phenotype
MH  - Prediabetic State/blood/*ethnology
MH  - Prevalence
MH  - Treatment Outcome
MH  - United States/epidemiology
MH  - White People
PMC - PMC7246091
MID - NIHMS1581377
OTO - NOTNLM
OT  - Dysglycemia
OT  - Impaired fasting glucose
OT  - Impaired glucose tolerance
OT  - Prediabetes
OT  - Race/Ethnicity
COIS- Conflict of Interest: The authors have no conflict of interest to disclose 
      regarding the content of this manuscript.
EDAT- 2020/05/04 06:00
MHDA- 2020/07/14 06:00
PMCR- 2021/05/01
CRDT- 2020/05/04 06:00
PHST- 2019/11/13 00:00 [received]
PHST- 2020/03/02 00:00 [revised]
PHST- 2020/03/04 00:00 [accepted]
PHST- 2020/05/04 06:00 [entrez]
PHST- 2020/05/04 06:00 [pubmed]
PHST- 2020/07/14 06:00 [medline]
PHST- 2021/05/01 00:00 [pmc-release]
AID - S0002-9629(20)30078-1 [pii]
AID - 10.1016/j.amjms.2020.03.005 [doi]
PST - ppublish
SO  - Am J Med Sci. 2020 May;359(5):266-270. doi: 10.1016/j.amjms.2020.03.005. Epub 
      2020 Mar 9.