PMID- 32359646
OWN - NLM
STAT- MEDLINE
DCOM- 20210623
LR  - 20210623
IS  - 1557-7988 (Electronic)
IS  - 0076-6879 (Linking)
VI  - 637
DP  - 2020
TI  - Natural ligands of RXR receptors.
PG  - 209-234
LID - S0076-6879(20)30084-7 [pii]
LID - 10.1016/bs.mie.2020.02.006 [doi]
AB  - Given the role of retinoid X receptors (RXRs) as promiscuous partners of 
      heterodimeric complexes with other members of the Nuclear Receptor (NR) 
      superfamily, RXR ligands (rexinoids) play fundamental roles in gene 
      transcription, since upon ligand binding either transcriptionally activate the 
      "permissive" subclass of heterodimers or synergize with partner ligands in the 
      "non-permissive" subclass of heterodimers. The collection of natural products 
      thus far reported to bind RXR are described, including those discovered by 
      high-throughput screening (HTS), mere serendipity, and a combination of those. 
      Detailed protocols for the diastereo- and enantioselective synthesis of 
      (R)-9-cis-13,14-dihydroretinoic acid, a putative natural RXR ligand, are 
      provided.
CI  - (c) 2020 Elsevier Inc. All rights reserved.
FAU - Garcia, Patricia
AU  - Garcia P
AD  - Departamento de Quimica Organica, Facultade de Quimica, CINBIO and IBIV, 
      Universidade de Vigo, Campus As Lagoas-Marcosende, Vigo, Spain.
FAU - Lorenzo, Paula
AU  - Lorenzo P
AD  - Departamento de Quimica Organica, Facultade de Quimica, CINBIO and IBIV, 
      Universidade de Vigo, Campus As Lagoas-Marcosende, Vigo, Spain.
FAU - de Lera, Angel R
AU  - de Lera AR
AD  - Departamento de Quimica Organica, Facultade de Quimica, CINBIO and IBIV, 
      Universidade de Vigo, Campus As Lagoas-Marcosende, Vigo, Spain. Electronic 
      address: qolera@uvigo.es.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200319
PL  - United States
TA  - Methods Enzymol
JT  - Methods in enzymology
JID - 0212271
RN  - 0 (Ligands)
RN  - 0 (Retinoid X Receptors)
SB  - IM
MH  - Ligands
MH  - *Retinoid X Receptors/genetics
OTO - NOTNLM
OT  - Agonists
OT  - Natural ligands
OT  - RXR
OT  - RXR heterodimers
OT  - Rexinoids
OT  - Synthesis
EDAT- 2020/05/04 06:00
MHDA- 2021/06/24 06:00
CRDT- 2020/05/04 06:00
PHST- 2020/05/04 06:00 [entrez]
PHST- 2020/05/04 06:00 [pubmed]
PHST- 2021/06/24 06:00 [medline]
AID - S0076-6879(20)30084-7 [pii]
AID - 10.1016/bs.mie.2020.02.006 [doi]
PST - ppublish
SO  - Methods Enzymol. 2020;637:209-234. doi: 10.1016/bs.mie.2020.02.006. Epub 2020 Mar 
      19.