PMID- 32359741
OWN - NLM
STAT- MEDLINE
DCOM- 20210924
LR  - 20210924
IS  - 2405-4577 (Electronic)
IS  - 2405-4577 (Linking)
VI  - 37
DP  - 2020 Jun
TI  - The effects of vitamin D and curcuminoids supplementation on anthropometric 
      measurements and blood pressure in type 2 diabetic patients with coexisting 
      hypovitaminosis D: A double-blind, placebo-controlled randomized clinical trial.
PG  - 178-186
LID - S2405-4577(20)30037-1 [pii]
LID - 10.1016/j.clnesp.2020.02.017 [doi]
AB  - BACKGROUND AND AIMS: Curcuminoids and vitamin D have been shown to improve blood 
      pressure and body weight in diabetic animals; however, consistent findings in 
      type 2 diabetes mellitus (T2DM) patients are limited. This study was performed to 
      evaluate the effects of curcuminoids and vitamin D, simultaneously or singly on 
      anthropometric measurements and blood pressure in T2DM patients with insufficient 
      vitamin D level. METHODS: In this randomized, placebo-controlled clinical trial, 
      eighty T2DM patients were randomly assigned into 4 groups receiving (1) 
      500 mg/day curcuminoids; (2) 50,000 IU/week vitamin D(3); (3) 50,000 IU/week 
      vitamin D(3) plus 500 mg/d curcuminoids; or (4) placebos for 12 weeks. Blood 
      pressure and anthropometric measurements were evaluated before and after 
      intervention. RESULTS: Intergroup comparisons showed that Vitamin D (main effect) 
      significantly reduced systolic blood pressure (SBP) and diastolic blood pressure 
      (DBP) (P = 0/000). Curcuminoids (main effect) significantly reduced DBP 
      (P = 0/001). Interaction effects showed that curcuminoids significantly prevented 
      the effect of vitamin D on the reduction of SBP (P = 0.006). Whereas, vitamin D 
      and curcuminoids had a synergistic effect on DBP reduction (P = 0.006). The 
      comparison of changes in anthropometric measurements between the four groups 
      showed no significant differences in the raw and adjusted models. In-group 
      comparisons showed that SBP, DBP, waist to hip circumference (WHR), body fat mass 
      (BFM), percent body fat (PBF) and visceral fat area (VFA) values were 
      significantly reduced in all groups except the placebo group compared to baseline 
      values. Only in the CR-D group, there was a significant reduction in body weight 
      (P = 0/047). CONCLUSIONS: Curcuminoids and vitamin D may have beneficial effects 
      on blood pressure and anthropometric measurements in T2DM patients. CLINICAL 
      REGISTRATION: http://www.IRCT.ir:IRCT2017041213678N22.
CI  - Copyright (c) 2020 European Society for Clinical Nutrition and Metabolism. 
      Published by Elsevier Ltd. All rights reserved.
FAU - Ebrahimkhani, Shirin
AU  - Ebrahimkhani S
AD  - Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran; 
      Department of Human Nutrition, Faculty of Medicine, Urmia University of Medical 
      Sciences, Urmia, Iran.
FAU - Ghavamzadeh, Saeid
AU  - Ghavamzadeh S
AD  - Department of Human Nutrition, Faculty of Medicine, Urmia University of Medical 
      Sciences, Urmia, Iran; Food and Beverages Safety Research Center, Urmia 
      University of Medical Sciences, Urmia, Iran. Electronic address: 
      Ghavamzadeh.saeid2019@gmail.com.
FAU - Mehdizadeh, Alireza
AU  - Mehdizadeh A
AD  - Department of Internal Medicine, Imam-Khomeini Training Hospital, Urmia 
      University of Medical Sciences, Urmia, Iran.
LA  - eng
SI  - IRCT/IRCT2017041213678N22
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20200320
PL  - England
TA  - Clin Nutr ESPEN
JT  - Clinical nutrition ESPEN
JID - 101654592
RN  - 0 (Diarylheptanoids)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Blood Pressure
MH  - *Diabetes Mellitus, Type 2/complications/drug therapy
MH  - Diarylheptanoids
MH  - Dietary Supplements
MH  - Humans
MH  - Vitamin D
MH  - *Vitamin D Deficiency/complications/drug therapy
OTO - NOTNLM
OT  - Anthropometric measurements
OT  - Blood pressure
OT  - Curcuminoids
OT  - Type 2 diabetes
OT  - Vitamin D
COIS- Declaration of Competing Interest None.
EDAT- 2020/05/04 06:00
MHDA- 2021/09/25 06:00
CRDT- 2020/05/04 06:00
PHST- 2019/12/02 00:00 [received]
PHST- 2020/02/20 00:00 [revised]
PHST- 2020/02/25 00:00 [accepted]
PHST- 2020/05/04 06:00 [entrez]
PHST- 2020/05/04 06:00 [pubmed]
PHST- 2021/09/25 06:00 [medline]
AID - S2405-4577(20)30037-1 [pii]
AID - 10.1016/j.clnesp.2020.02.017 [doi]
PST - ppublish
SO  - Clin Nutr ESPEN. 2020 Jun;37:178-186. doi: 10.1016/j.clnesp.2020.02.017. Epub 
      2020 Mar 20.