PMID- 32361292 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240227 IS - 1618-095X (Electronic) IS - 0944-7113 (Linking) VI - 70 DP - 2020 Apr 22 TI - Modulation of interleukin expression by medicinal plants and their secondary metabolites: A systematic review on anti-asthmatic and immunopharmacological mechanisms. PG - 153229 LID - S0944-7113(20)30060-X [pii] LID - 10.1016/j.phymed.2020.153229 [doi] AB - BACKGROUND: Asthma is one of the most common chronic inflammatory conditions of the lungs in modern society. Asthma is associated with airway hyperresponsiveness and remodeling of the airways, with typical symptoms of cough, wheezing, shortness of breath and chest tightness. Interleukins (IL) play an integral role in its inflammatory pathogenesis. Medicinal herbs and secondary metabolites are gaining considerable attention due to their potential therapeutic role and pharmacological mechanisms as adjunct tools to synthetic bronchodilator drugs. PURPOSE: To systematically review the literature on the use of single or mixed plants extracts therapy in vivo experimental systems for asthma, emphasizing their regulations on IL production to improve lung. METHODS: Literature searches were performed on PubMed, EMBASE, Scopus and Web of Science databases. All articles in English were extracted from 1999 up to September 2019, assessed critically for data extraction. Studies investigating the effectiveness and safety of plant extracts administered; inflammatory cell count, immunoglobulin E (IgE) production and regulation of pro-inflammatory cytokine and T helper (Th) 1 and Th2-driven cytokine expression in bronchoalveolar lavage fluid (BALF) and lung of asthmatic animals were included. RESULTS: Four hundred and eighteen publications were identified and 51 met the inclusion criteria. Twenty-six studies described bioactive compounds from plant extracts. The most frequent immunopharmacological mechanisms described included reduction in IgE and eosinophilic recruitment, decreased mucus hypersecretion and airway hyperreactivity, enhancement of the balance of Th1/Th2 cytokine ratio, suppression of matrix metallopeptidase 9 (MMP-9) and reversal of structural alterations. CONCLUSION: Plant extract therapies have potential control activities on asthma symptoms by modulating the secretion of pro-inflammatory (IL-1beta, IL-8), Th17 (IL-17), anti-inflammatory (IL-10, IL-23, IL-31, IL-33), Th1 (IL-2, IL-12) and Th2 (IL-4, IL-5, IL-6, IL-13) cytokines, reducing the level of biomarkers of airway inflammation. CI - Copyright (c) 2020 Elsevier GmbH. All rights reserved. FAU - Gandhi, Gopalsamy Rajiv AU - Gandhi GR AD - Graduate Program in Health Sciences, Federal University of Sergipe, Rua Claudio Batista, s/n, Cidade Nova, Aracaju, 49.100-000 Sergipe, Brazil. FAU - Leao, Gabriel Campos de Sousa AU - Leao GCS AD - Department of Medicine, Federal University of Sergipe, Rua Claudio Batista, s/n, Cidade Nova, Aracaju, 49.100-000, Sergipe, Brazil. FAU - Calisto, Valdete Kaliane da Silva AU - Calisto VKDS AD - Graduate Program in Health Sciences, Federal University of Sergipe, Rua Claudio Batista, s/n, Cidade Nova, Aracaju, 49.100-000 Sergipe, Brazil. FAU - Vasconcelos, Alan Bruno Silva AU - Vasconcelos ABS AD - Graduate Program in Physiological Sciences, Federal University of Sergipe, Sao Cristovao, 49.100-000, Sergipe, Brazil. FAU - Almeida, Maria Luiza Doria AU - Almeida MLD AD - Graduate Program in Health Sciences, Federal University of Sergipe, Rua Claudio Batista, s/n, Cidade Nova, Aracaju, 49.100-000 Sergipe, Brazil; Department of Medicine, Federal University of Sergipe, Rua Claudio Batista, s/n, Cidade Nova, Aracaju, 49.100-000, Sergipe, Brazil. FAU - Quintans, Jullyana de Souza Siqueira AU - Quintans JSS AD - Graduate Program in Health Sciences, Federal University of Sergipe, Rua Claudio Batista, s/n, Cidade Nova, Aracaju, 49.100-000 Sergipe, Brazil; Laboratory of Neurosciences and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, Sao Cristovao, 49.100-000 Sergipe, Brazil. FAU - Barreto, Emiliano AU - Barreto E AD - Laboratory of Molecular Biology, Institute of Biological Sciences, Federal University of Alagoas, Maceio, 57.072-900 Alagoas, Brazil. FAU - Narain, Narendra AU - Narain N AD - Laboratory of Flavor and Chromatographic Analysis, Federal University of Sergipe, Sao Cristovao, Aracaju, 49.100-000 Sergipe, Brazil. FAU - Junior, Lucindo Jose Quintans AU - Junior LJQ AD - Graduate Program in Health Sciences, Federal University of Sergipe, Rua Claudio Batista, s/n, Cidade Nova, Aracaju, 49.100-000 Sergipe, Brazil; Laboratory of Neurosciences and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, Sao Cristovao, 49.100-000 Sergipe, Brazil. FAU - Gurgel, Ricardo Queiroz AU - Gurgel RQ AD - Graduate Program in Health Sciences, Federal University of Sergipe, Rua Claudio Batista, s/n, Cidade Nova, Aracaju, 49.100-000 Sergipe, Brazil; Department of Medicine, Federal University of Sergipe, Rua Claudio Batista, s/n, Cidade Nova, Aracaju, 49.100-000, Sergipe, Brazil. Electronic address: ricardoqgurgel@gmail.com. LA - eng PT - Journal Article PT - Review DEP - 20200422 PL - Germany TA - Phytomedicine JT - Phytomedicine : international journal of phytotherapy and phytopharmacology JID - 9438794 SB - IM OTO - NOTNLM OT - Airway hyperresponsiveness OT - Asthma OT - Cytokine OT - Interleukin OT - Medicinal plants COIS- Declaration of Competing Interest The authors declare that there is no conflict of interest on the publication of this paper. EDAT- 2020/05/04 06:00 MHDA- 2020/05/04 06:01 CRDT- 2020/05/04 06:00 PHST- 2019/10/23 00:00 [received] PHST- 2020/03/09 00:00 [revised] PHST- 2020/04/13 00:00 [accepted] PHST- 2020/05/04 06:01 [medline] PHST- 2020/05/04 06:00 [pubmed] PHST- 2020/05/04 06:00 [entrez] AID - S0944-7113(20)30060-X [pii] AID - 10.1016/j.phymed.2020.153229 [doi] PST - aheadofprint SO - Phytomedicine. 2020 Apr 22;70:153229. doi: 10.1016/j.phymed.2020.153229.