PMID- 32361369
OWN - NLM
STAT- MEDLINE
DCOM- 20210614
LR  - 20210614
IS  - 1872-6968 (Electronic)
IS  - 0303-8467 (Linking)
VI  - 195
DP  - 2020 Aug
TI  - Risk factors for the recurrence of world health organization grade Ⅱ ependymomas 
      of spinal cord in adults after microsurgical resections: A retrospective study of 
      118 patients in a single center.
PG  - 105856
LID - S0303-8467(20)30199-2 [pii]
LID - 10.1016/j.clineuro.2020.105856 [doi]
AB  - OBJECTIVE: To identify the risk factors for recurrence of World Health 
      Organization (WHO) grade Ⅱ ependymomas of spinal cord in adults after 
      microsurgical resections. PATIENTS AND METHODS: A total of 118 adult patients 
      diagnosed with WHO grade Ⅱ ependymomas of spinal cord at west china hospital from 
      January 2010 to December 2016 were reviewed retrospectively. To identify the risk 
      factors for recurrence, we performed univariate analyses and multivariate 
      logistic regression analyses successively. RESULTS: Twelve patients had a 
      recurrence with a median recurrence time of 30 months [inter-quartile range (IQR) 
      23.5-75.5 months]. Univariate analysis showed that age (p = 0.030), STR 
      (p < 0.001), index of Ki-67 (p = 0.004), and Vimentin (+, p = 0.004) were 
      associated with postoperative recurrence of ependymomas of spinal cord in adults, 
      while univariate analysis showed that only STR [odds ratio (OR) = 18.838, 95 % 
      confidence interval (CI): 3.068-115.673; p = 0.002], index of Ki-67 (OR = 1.381, 
      95 % CI: 1.021-1.868; p = 0.036), Vimentin (+; OR = 6.706, 95 % CI: 1.218-36.928; 
      p = 0.029) were independent risk factors for recurrence. CONCLUSIONS: The 
      recurrence rate of WHO grade Ⅱ ependymomas of spinal cord in adults was about 
      13.6 %. Subtotal resection is a critical risk factor for recurrence. A high index 
      of Ki-67 is another independent risk factor for recurrence. Positive Vimentin may 
      also play a role in this process. GTR is very important to prevent recurrence 
      after operation if it is safe to conduct. In cases with higher index Ki-67 and 
      Vimentin (+), close follow-ups are necessary.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Deng, Yong
AU  - Deng Y
AD  - Departments of Neurosurgery, West China Hospital of Sichuan University, PR China.
FAU - Chen, Haifeng
AU  - Chen H
AD  - Departments of Neurosurgery, West China Hospital of Sichuan University, PR China.
FAU - Wang, Chenghong
AU  - Wang C
AD  - Departments of Neurosurgery, West China Hospital of Sichuan University, PR China.
FAU - Zhang, Yuekang
AU  - Zhang Y
AD  - Departments of Neurosurgery, West China Hospital of Sichuan University, PR China. 
      Electronic address: 2012zykyx@sina.cn.
LA  - eng
PT  - Journal Article
DEP - 20200418
PL  - Netherlands
TA  - Clin Neurol Neurosurg
JT  - Clinical neurology and neurosurgery
JID - 7502039
SB  - IM
MH  - Adult
MH  - Disease-Free Survival
MH  - Ependymoma/mortality/pathology/*surgery
MH  - Female
MH  - Humans
MH  - Male
MH  - Microsurgery/methods
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/*epidemiology
MH  - Neurosurgical Procedures/methods
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Spinal Cord Neoplasms/mortality/pathology/*surgery
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Ependymomas of spinal cord
OT  - Ki-67
OT  - Microsurgical resection
OT  - Recurrence
OT  - Risk factor
OT  - Vimentin
EDAT- 2020/05/04 06:00
MHDA- 2021/06/16 06:00
CRDT- 2020/05/04 06:00
PHST- 2020/01/16 00:00 [received]
PHST- 2020/04/11 00:00 [revised]
PHST- 2020/04/13 00:00 [accepted]
PHST- 2020/05/04 06:00 [pubmed]
PHST- 2021/06/16 06:00 [medline]
PHST- 2020/05/04 06:00 [entrez]
AID - S0303-8467(20)30199-2 [pii]
AID - 10.1016/j.clineuro.2020.105856 [doi]
PST - ppublish
SO  - Clin Neurol Neurosurg. 2020 Aug;195:105856. doi: 10.1016/j.clineuro.2020.105856. 
      Epub 2020 Apr 18.