PMID- 32361944
OWN - NLM
STAT- MEDLINE
DCOM- 20210427
LR  - 20210427
IS  - 1931-7565 (Electronic)
IS  - 1931-7557 (Linking)
VI  - 15
IP  - 2
DP  - 2021 Apr
TI  - Enhanced cerebro-cerebellar functional connectivity reverses cognitive impairment 
      following electroconvulsive therapy in major depressive disorder.
PG  - 798-806
LID - 10.1007/s11682-020-00290-x [doi]
AB  - Electroconvulsive therapy (ECT), a rapidly acting and effective treatment for 
      major depressive disorder (MDD), is frequently accompanied by cognitive 
      impairment. Recent studies have documented that ECT reorganizes dysregulated 
      inter/intra- connected cerebral networks, including the affective network, the 
      cognitive control network(CCN) and default mode network (DMN).Moreover, 
      cerebellum is thought to play an important role in emotion regulation and 
      cognitive processing. However, little is known about the relationship between 
      cerebro-cerebellar connectivity alterations following ECT and antidepressant 
      effects or cognitive impairment. We performed seed-based resting-state functional 
      connectivity (RSFC) analyses in 28 MDD patients receiving ECT and 20 healthy 
      controls to identify cerebro-cerebellar connectivity differences related to MDD 
      and changes induced by ECT. Six seed regions (three per hemisphere) in the 
      cerebrum were selected for RSFC, corresponding to the affective network, CCN and 
      DMN, to establish cerebro-cerebellar functional connectivity with cerebellum. MDD 
      patients showed increased RSFC between left sgACC and left cerebellar lobule VI 
      after ECT. Ggranger causality analyses (GCA) identified the causal interaction is 
      from left cerebellar lobule VI to left sgACC. Furthermore, increased effective 
      connectivity from left cerebellar lobule VI to left sgACC exhibited positively 
      correlated with the change in verbal fluency test (VFT) score following ECT 
      (r = 0.433, p = 0.039). Our findings indicate that the enhanced 
      cerebro-cerebellar functional connectivity from left lobule VI to left sgACC may 
      ameliorate cognitive impairment induced by ECT. This study identifies a potential 
      neural pathway for mitigation of cognitive impairment following ECT.
FAU - Wei, Qiang
AU  - Wei Q
AD  - Department of Neurology, the First Affiliated Hospital of Anhui Medical 
      University, 230022, Hefei, Anhui Province, China.
AD  - Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, 
      Hefei, China.
FAU - Ji, Yang
AU  - Ji Y
AD  - Department of Neurology, the First Affiliated Hospital of Anhui Medical 
      University, 230022, Hefei, Anhui Province, China.
FAU - Bai, Tongjian
AU  - Bai T
AD  - Department of Neurology, the First Affiliated Hospital of Anhui Medical 
      University, 230022, Hefei, Anhui Province, China.
AD  - Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, 
      Hefei, China.
FAU - Zu, Meidan
AU  - Zu M
AD  - Department of Neurology, the First Affiliated Hospital of Anhui Medical 
      University, 230022, Hefei, Anhui Province, China.
FAU - Guo, Yuanyuan
AU  - Guo Y
AD  - Department of Neurology, the First Affiliated Hospital of Anhui Medical 
      University, 230022, Hefei, Anhui Province, China.
FAU - Mo, Yuting
AU  - Mo Y
AD  - Department of Neurology, the First Affiliated Hospital of Anhui Medical 
      University, 230022, Hefei, Anhui Province, China.
FAU - Ji, Gongjun
AU  - Ji G
AD  - Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, 
      Hefei, China.
FAU - Wang, Kai
AU  - Wang K
AD  - Department of Neurology, the First Affiliated Hospital of Anhui Medical 
      University, 230022, Hefei, Anhui Province, China. wangkai1964@126.com.
AD  - Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, 
      Hefei, China. wangkai1964@126.com.
AD  - Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, 
      230022, Hefei, China. wangkai1964@126.com.
AD  - Department of Medical Psychology, Anhui Medical University, 230022, Hefei, China. 
      wangkai1964@126.com.
FAU - Tian, Yanghua
AU  - Tian Y
AD  - Department of Neurology, the First Affiliated Hospital of Anhui Medical 
      University, 230022, Hefei, Anhui Province, China. ayfytyh@126.comY.T.
AD  - Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, 
      Hefei, China. ayfytyh@126.comY.T.
LA  - eng
GR  - 81601187/National Natural Science Foundation of China/
GR  - 81671354/National Natural Science Foundation of China/
PT  - Journal Article
PL  - United States
TA  - Brain Imaging Behav
JT  - Brain imaging and behavior
JID - 101300405
SB  - IM
MH  - Cerebellum/diagnostic imaging
MH  - *Cognitive Dysfunction
MH  - *Depressive Disorder, Major/diagnostic imaging/therapy
MH  - *Electroconvulsive Therapy
MH  - Humans
MH  - Magnetic Resonance Imaging
OTO - NOTNLM
OT  - Cerebellum
OT  - Cognitive impairment
OT  - Electroconvulsive therapy
OT  - Major depressive disorder
OT  - Resting-state fMRI
EDAT- 2020/05/04 06:00
MHDA- 2021/04/28 06:00
CRDT- 2020/05/04 06:00
PHST- 2020/05/04 06:00 [pubmed]
PHST- 2021/04/28 06:00 [medline]
PHST- 2020/05/04 06:00 [entrez]
AID - 10.1007/s11682-020-00290-x [pii]
AID - 10.1007/s11682-020-00290-x [doi]
PST - ppublish
SO  - Brain Imaging Behav. 2021 Apr;15(2):798-806. doi: 10.1007/s11682-020-00290-x.