PMID- 32362066
OWN - NLM
STAT- MEDLINE
DCOM- 20210623
LR  - 20210623
IS  - 1864-0648 (Electronic)
IS  - 1864-063X (Linking)
VI  - 13
IP  - 8
DP  - 2020 Aug
TI  - Transcranial photobiomodulation attenuates pentylenetetrazole-induced status 
      epilepticus in peripubertal rats.
PG  - e202000095
LID - 10.1002/jbio.202000095 [doi]
AB  - Convulsive status epilepticus is the most common neurological emergency in 
      children. Transcranial photobiomodulation (tPBM) reverses elevated rodent 
      neurotransmitters after status epilepticus (SE) yet whether tPBM can attenuate 
      seizure behaviors remains unknown. Here, we applied near-infrared laser at 
      wavelength 808 nm transcranially to peripubertal Sprague-Dawley rats prior to 
      pentylenetetrazole (PTZ) injection. Hematoxylin-eosin, immunofluorescence (IF) 
      staining with anti-parvalbumin (PV) and terminal deoxynucleotidyl transferase 
      dUTP nick-end labeling (TUNEL) assay after IF staining was performed. 
      Behaviorally, tPBM attenuated the mean seizure score and reduced the incidence of 
      SE and mortality. Histochemically, tPBM reduced dark neurons in the cortex, 
      hippocampus, thalamus and hypothalamus, lessened the apoptotic ratio of 
      parvalbumin-positive interneurons (PV-INs) and alleviated the aberrant extent of 
      PV-positive unstained somata of PCs in the hippocampus. Conclusively, tPBM 
      attenuated PTZ-induced seizures, SE and mortality in peripubertal rats and 
      reduced PTZ-induced neuronal injury, apoptosis of PV-INs and preserved PV 
      positive perisomatic inhibitory network in the hippocampus.
CI  - (c) 2020 The Authors. Journal of Biophotonics published by WILEY-VCH Verlag GmbH & 
      Co. KGaA, Weinheim.
FAU - Tsai, Chung-Min
AU  - Tsai CM
AUID- ORCID: 0000-0001-8761-5101
AD  - Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical 
      University, Taipei, Taiwan.
FAU - Chang, Shwu-Fen
AU  - Chang SF
AD  - Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical 
      University, Taipei, Taiwan.
FAU - Chang, Hsi
AU  - Chang H
AUID- ORCID: 0000-0003-1151-005X
AD  - Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical 
      University, Taipei, Taiwan.
AD  - Department of Pediatrics, Taipei Medical University Hospital, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20200518
PL  - Germany
TA  - J Biophotonics
JT  - Journal of biophotonics
JID - 101318567
RN  - WM5Z385K7T (Pentylenetetrazole)
SB  - IM
MH  - Animals
MH  - Hippocampus
MH  - *Pentylenetetrazole
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Seizures/chemically induced
MH  - *Status Epilepticus/chemically induced
OTO - NOTNLM
OT  - PTZ
OT  - apoptosis
OT  - hippocampus
OT  - parvalbumin-positive interneurons
OT  - seizures
OT  - transcranial photobiomodulation
EDAT- 2020/05/04 06:00
MHDA- 2021/06/24 06:00
CRDT- 2020/05/04 06:00
PHST- 2020/03/15 00:00 [received]
PHST- 2020/04/25 00:00 [revised]
PHST- 2020/04/28 00:00 [accepted]
PHST- 2020/05/04 06:00 [pubmed]
PHST- 2021/06/24 06:00 [medline]
PHST- 2020/05/04 06:00 [entrez]
AID - 10.1002/jbio.202000095 [doi]
PST - ppublish
SO  - J Biophotonics. 2020 Aug;13(8):e202000095. doi: 10.1002/jbio.202000095. Epub 2020 
      May 18.