PMID- 32362164
OWN - NLM
STAT- MEDLINE
DCOM- 20210927
LR  - 20210927
IS  - 1473-0766 (Electronic)
IS  - 0951-3590 (Linking)
VI  - 36
IP  - 12
DP  - 2020 Dec
TI  - Ovarian reserve markers and endocrine profile during oral contraception: Is there 
      a link between the degree of ovarian suppression and AMH?
PG  - 1090-1095
LID - 10.1080/09513590.2020.1756250 [doi]
AB  - The ovarian reserve markers anti-Mullerian hormone (AMH) and antral follicle 
      count (AFC) are suppressed in varying degree during the use of combined oral 
      contraceptives (COC). Further, long-term use of COC can mask a condition of 
      premature ovarian insufficiency. A desirable clinical tool that could distinguish 
      true low ovarian reserve markers from COC-induced low levels during use of COC is 
      warranted. The aim of this multicenter study including 235 COC users was to 
      assess whether low age-adjusted AMH levels during COC use were linked to 
      concomitant low levels of LH, FSH, estradiol and androgens - as a potential 
      future tool to differentiate between 'false', COC-induced low AMH levels vs. true 
      low AMH. Study population and methods: In total, 235 COC users from the general 
      population aged 19-40 years were included. AMH, AFC and a reproductive hormonal 
      profile were measured during COC intake. Age-adjusted AMH levels (Z-scores) were 
      calculated from a comparison group of 983 non-users of COC. Differences in 
      hormonal profile were tested between women with low versus high age-adjusted 
      AMH-quartiles based on non-parametric Wilcoxon rank sum tests. The outcomes of 
      interest were levels of gonadotropins, estradiol and androgens according to the 
      four the age-adjusted AMH quartiles to find out if women with low age-adjusted 
      AMH levels had a stronger gonadotropin suppression compared with women with 
      higher age-adjusted AMH levels. Mean age of COC users was 30.2 years (SD 3.8), 
      median AMH 14 pmol/l (inter-quartile range (IQR) 8.7-23)), median AFC 16 (IQR 
      11-25). We found no significant differences across the age-adjusted AMH quartiles 
      in either the levels of gonadotropins, estrogens or androgens, respectively. 
      Thus, the degree of suppression of FSH, LH, androgens and estradiol are unlikely 
      to be a useful tool to differentiate between false low and true low ovarian 
      reserve markers during COC use. Presently, there seems to be no alternative to 
      withdrawal of the COC and to re-test the ovarian reserve after 2-3 months. Trial 
      registration Trial no. NCT02785809 (www.clinicaltrials.gov).
FAU - Landersoe, Selma Kloeve
AU  - Landersoe SK
AD  - The Fertility Clinic, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 
      Denmark.
FAU - Larsen, Elisabeth Clare
AU  - Larsen EC
AD  - The Fertility Clinic, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 
      Denmark.
FAU - Forman, Julie Lyng
AU  - Forman JL
AD  - Section of Biostatistics, Department of Public Health, University of Copenhagen, 
      Copenhagen, Denmark.
FAU - Birch Petersen, Kathrine
AU  - Birch Petersen K
AD  - The Fertility Clinic, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 
      Denmark.
AD  - The Fertility Clinic, Zealand University Hospital, Koge, Denmark.
FAU - Kroman, Mie Stougaard
AU  - Kroman MS
AD  - The Fertility Clinic, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 
      Denmark.
FAU - Frederiksen, Hanne
AU  - Frederiksen H
AD  - Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, 
      Copenhagen, Denmark.
FAU - Juul, Anders
AU  - Juul A
AD  - Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, 
      Copenhagen, Denmark.
FAU - Nohr, Bugge
AU  - Nohr B
AD  - The Fertility Clinic, Herlev Hospital, Herlev, Denmark.
FAU - Lossl, Kristine
AU  - Lossl K
AD  - The Fertility Clinic, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 
      Denmark.
FAU - Nielsen, Henriette Svarre
AU  - Nielsen HS
AD  - The Fertility Clinic, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 
      Denmark.
FAU - Nyboe Andersen, Anders
AU  - Nyboe Andersen A
AD  - The Fertility Clinic, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 
      Denmark.
LA  - eng
SI  - ClinicalTrials.gov/NCT02785809
PT  - Journal Article
DEP - 20200502
PL  - England
TA  - Gynecol Endocrinol
JT  - Gynecological endocrinology : the official journal of the International Society 
      of Gynecological Endocrinology
JID - 8807913
RN  - 0 (Androgens)
RN  - 0 (Contraceptives, Oral, Combined)
RN  - 4TI98Z838E (Estradiol)
RN  - 80497-65-0 (Anti-Mullerian Hormone)
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Androgens/blood
MH  - Anti-Mullerian Hormone/*blood
MH  - Contraceptives, Oral, Combined/*therapeutic use
MH  - Cross-Sectional Studies
MH  - Estradiol/blood
MH  - Female
MH  - Follicle Stimulating Hormone/blood
MH  - Humans
MH  - Luteinizing Hormone/blood
MH  - Ovarian Follicle/*diagnostic imaging
MH  - *Ovarian Reserve
OTO - NOTNLM
OT  - AMH
OT  - antral follicle count
OT  - oral contraceptives
OT  - ovarian reserve markers
EDAT- 2020/05/05 06:00
MHDA- 2021/09/28 06:00
CRDT- 2020/05/05 06:00
PHST- 2020/05/05 06:00 [pubmed]
PHST- 2021/09/28 06:00 [medline]
PHST- 2020/05/05 06:00 [entrez]
AID - 10.1080/09513590.2020.1756250 [doi]
PST - ppublish
SO  - Gynecol Endocrinol. 2020 Dec;36(12):1090-1095. doi: 
      10.1080/09513590.2020.1756250. Epub 2020 May 2.