PMID- 32362824
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220414
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 11
DP  - 2020
TI  - Shenmai Injection Improves Energy Metabolism in Patients With Heart Failure: A 
      Randomized Controlled Trial.
PG  - 459
LID - 10.3389/fphar.2020.00459 [doi]
LID - 459
AB  - BACKGROUND: In recent years, the application of Shenmai (SM) injection, a 
      traditional Chinese medicine (TCM), to treat heart failure (HF) has been 
      gradually accepted in China. However, whether SM improves energy metabolism in 
      patients with HF has not been determined due to the lack of high-quality studies. 
      We aimed to investigate the influence of SM on energy metabolism in patients with 
      HF. METHODS: This single-blind, controlled study randomly assigned 120 eligible 
      patients equally into three groups receiving SM, trimetazidine (TMZ), or control 
      in addition to standard medical treatment for HF for 7 days. The primary 
      endpoints were changes in free fatty acids (FFAs), glucose, lactic acid (LA), 
      pyroracemic acid (pyruvate, PA) and branched chain amino acids (BCAAs) in serum. 
      The secondary outcomes included the New York Heart Association (NYHA) functional 
      classification, TCM syndrome score (TCM-s), left ventricular injection fraction 
      (LVEF), left ventricular internal diastolic diameter (LVIDd), left ventricular 
      internal dimension systole (LVIDs), and B-type natriuretic peptide (BNP). 
      RESULTS: After treatment for 1 week, the NYHA functional classification, TCM-s, 
      and BNP level gradually decreased in the patients in all three groups, but these 
      metrics were significantly increased in the patients in the SM group compared 
      with those in the patients in the TMZ and control groups (P < 0.05). Moreover, 
      energy metabolism was improved in the NYHA III-IV patients in the SM group 
      compared with those in the patients in the TMZ and control groups as evidenced by 
      changes in the serum levels of FFA, LA, PA, and BCAA. CONCLUSIONS: Integrative 
      treatment with SM in addition to standard medical treatment for HF was associated 
      with improved cardiac function compared to standard medical treatment alone. The 
      benefit of SM in HF may be related to an improvement in energy metabolism, which 
      seems to be more remarkable than that following treatment with TMZ.
CI  - Copyright (c) 2020 Wang, Ye and Wang.
FAU - Wang, Shao-Mei
AU  - Wang SM
AD  - Cardiovascular Medicine Department, People's Hospital of Hangzhou Medical 
      College, Hangzhou, China.
AD  - Bengbu Medical College, Bengbu, China.
FAU - Ye, Li-Fang
AU  - Ye LF
AD  - Cardiovascular Medicine Department, People's Hospital of Hangzhou Medical 
      College, Hangzhou, China.
FAU - Wang, Li-Hong
AU  - Wang LH
AD  - Cardiovascular Medicine Department, People's Hospital of Hangzhou Medical 
      College, Hangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20200417
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC7181884
OTO - NOTNLM
OT  - Shenmai injection
OT  - cardiac function
OT  - energy metabolism
OT  - heart failure
OT  - traditional Chinese medicine
EDAT- 2020/05/05 06:00
MHDA- 2020/05/05 06:01
PMCR- 2020/04/17
CRDT- 2020/05/05 06:00
PHST- 2019/12/09 00:00 [received]
PHST- 2020/03/24 00:00 [accepted]
PHST- 2020/05/05 06:00 [entrez]
PHST- 2020/05/05 06:00 [pubmed]
PHST- 2020/05/05 06:01 [medline]
PHST- 2020/04/17 00:00 [pmc-release]
AID - 10.3389/fphar.2020.00459 [doi]
PST - epublish
SO  - Front Pharmacol. 2020 Apr 17;11:459. doi: 10.3389/fphar.2020.00459. eCollection 
      2020.