PMID- 32363609
OWN - NLM
STAT- MEDLINE
DCOM- 20210818
LR  - 20210818
IS  - 1521-1878 (Electronic)
IS  - 0265-9247 (Linking)
VI  - 42
IP  - 6
DP  - 2020 Jun
TI  - Lipophilic Environmental Chemical Mixtures Released During Weight-Loss: The Need 
      to Consider Dynamics.
PG  - e1900237
LID - 10.1002/bies.201900237 [doi]
AB  - Intentional weight loss can increase health risk in the long-term, despite 
      short-term benefits, because human adipose tissue is widely contaminated with 
      various lipophilic environmental contaminants, especially persistent organic 
      pollutants (POPs). Recently, chronic exposure to low POPs has emerged as a new 
      risk factor for common metabolic diseases and cardiovascular diseases. The amount 
      of POPs released from adipocytes to the circulation increases during weight loss, 
      thereby increasing POPs exposure of other critical organs. Possible harmful 
      effects due to release of POPs during weight loss are opposite to those usually 
      expected from losing weight. It is speculated that this tradeoff can explain 
      recent puzzling findings on intensive weight loss. The presence of POPs in 
      adipose tissue adds a challenge to weight management and an optimal strategy of 
      weight management needs to consider both fat mass and dynamics of POPs.
CI  - (c) 2020 WILEY Periodicals, Inc.
FAU - Lee, Duk-Hee
AU  - Lee DH
AUID- ORCID: 0000-0003-1596-9968
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, Daegu, 41944, Korea.
FAU - Jacobs, David R Jr
AU  - Jacobs DR Jr
AD  - Division of Epidemiology and Community Health, School of Public Health, 
      University of Minnesota, Minneapolis, Minnesota, 55454, USA.
FAU - Lind, Lars
AU  - Lind L
AD  - Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, 
      Uppsala, 75237, Sweden.
FAU - Lind, P Monica
AU  - Lind PM
AD  - Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala 
      University, Uppsala, 75185, Sweden.
LA  - eng
GR  - Ministry of Science and ICT of the Republic of Korea/International
GR  - 2019R1A2C1008958/National Research Foundation of Korea/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200504
PL  - United States
TA  - Bioessays
JT  - BioEssays : news and reviews in molecular, cellular and developmental biology
JID - 8510851
RN  - 0 (Environmental Pollutants)
SB  - IM
CIN - Bioessays. 2020 Jun;42(6):e2000069. PMID: 32363575
MH  - Adipose Tissue
MH  - *Environmental Pollutants/analysis
MH  - Humans
MH  - Obesity
MH  - Risk Factors
MH  - *Weight Loss
OTO - NOTNLM
OT  - cardiovascular diseases
OT  - diabetes
OT  - obesity
OT  - persistent organic pollutants
OT  - weight loss
EDAT- 2020/05/05 06:00
MHDA- 2021/08/19 06:00
CRDT- 2020/05/05 06:00
PHST- 2019/12/05 00:00 [received]
PHST- 2020/03/06 00:00 [revised]
PHST- 2020/05/05 06:00 [pubmed]
PHST- 2021/08/19 06:00 [medline]
PHST- 2020/05/05 06:00 [entrez]
AID - 10.1002/bies.201900237 [doi]
PST - ppublish
SO  - Bioessays. 2020 Jun;42(6):e1900237. doi: 10.1002/bies.201900237. Epub 2020 May 4.