PMID- 32364029
OWN - NLM
STAT- MEDLINE
DCOM- 20201224
LR  - 20201224
IS  - 1944-0057 (Electronic)
IS  - 1944-0057 (Linking)
VI  - 37
IP  - 7
DP  - 2020 Jul
TI  - Quantification of persistent organic pollutants in dietary supplements using stir 
      bar sorptive extraction coupled with GC-MS/MS and isotope dilution mass 
      spectrometry.
PG  - 1202-1215
LID - 10.1080/19440049.2020.1749315 [doi]
AB  - In this work, we describe a method developed to quantify persistent organic 
      pollutants (POPs) including polycyclic aromatic hydrocarbons (PAHs) and 
      organochlorine pesticides (OCPs) in dietary supplement samples using stir-bar 
      sorptive extraction (SBSE)-GC-MS/MS-isotope dilution mass spectrometry (IDMS). 
      This method enables accurate, precise, and sensitive quantification of POPs in 
      plant-extract based dietary supplement products commercially available in the 
      United States. When compared with calibration curves, IDMS provided more accurate 
      and precise measurements. The mean error of measurements using this method was 
      7.24% with a mean RSD of 8.26%. The application of GC-MS/MS enabled approximately 
      two-order-of-magnitude lower limit of quantifications compared with GC-MS. 12 
      commercially available plant-extract based dietary supplement samples were 
      analysed using this method. PAHs including naphthalene, acenaphthene, fluorene, 
      phenanthrene, fluoranthene, pyrene, chrysene, and benzo[a]pyrene were detected in 
      most of the products and had average concentrations over 1 ng/g. OCPs were 
      detected less frequently than PAHs in these products, and none of the OCPs had 
      mean concentrations over 1 ng/g. The mean toxin concentration of each product was 
      calculated, and the highest value was 3.20 ng/g. These results were compared with 
      existing guidelines and none of the analytes in the samples were found to be 
      above the daily allowable limits.
FAU - Hao, Weier
AU  - Hao W
AUID- ORCID: 0000-0003-2313-4936
AD  - Department of Chemistry and Biochemistry, Duquesne University , Pittsburgh, PA, 
      USA.
FAU - Kingston, H M 'Skip'
AU  - Kingston HM'
AD  - Department of Chemistry and Biochemistry, Duquesne University , Pittsburgh, PA, 
      USA.
FAU - Dillard, Ashley
AU  - Dillard A
AD  - Department of Chemistry and Biochemistry, Duquesne University , Pittsburgh, PA, 
      USA.
FAU - Stuff, John
AU  - Stuff J
AD  - GERSTEL, Inc. , Linthicum, MD, USA.
FAU - Pamuku, Matt
AU  - Pamuku M
AD  - Applied Isotope Technologies , Sunnyvale, CA, USA.
LA  - eng
PT  - Journal Article
DEP - 20200503
PL  - England
TA  - Food Addit Contam Part A Chem Anal Control Expo Risk Assess
JT  - Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & 
      risk assessment
JID - 101485040
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
SB  - IM
MH  - Chromatography, Gas
MH  - Dietary Supplements/*analysis
MH  - Environmental Monitoring
MH  - Hydrocarbons, Chlorinated/*analysis
MH  - Indicator Dilution Techniques
MH  - Isotope Labeling
MH  - Mass Spectrometry
MH  - Pesticides/*analysis
MH  - Polycyclic Aromatic Hydrocarbons/*analysis
OTO - NOTNLM
OT  - GC-MS/MS
OT  - Persistent organic pollutants
OT  - dietary supplements
OT  - isotope dilution mass spectrometry
OT  - stir-bar sorptive extraction
EDAT- 2020/05/05 06:00
MHDA- 2020/12/29 06:00
CRDT- 2020/05/05 06:00
PHST- 2020/05/05 06:00 [pubmed]
PHST- 2020/12/29 06:00 [medline]
PHST- 2020/05/05 06:00 [entrez]
AID - 10.1080/19440049.2020.1749315 [doi]
PST - ppublish
SO  - Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2020 
      Jul;37(7):1202-1215. doi: 10.1080/19440049.2020.1749315. Epub 2020 May 3.