PMID- 32364939
OWN - NLM
STAT- MEDLINE
DCOM- 20210208
LR  - 20210208
IS  - 1873-4235 (Electronic)
IS  - 0956-5663 (Linking)
VI  - 159
DP  - 2020 Jul 1
TI  - Enhancement of cortisol measurement sensitivity by laser illumination for 
      AlGaN/GaN transistor biosensor.
PG  - 112186
LID - S0956-5663(20)30183-4 [pii]
LID - 10.1016/j.bios.2020.112186 [doi]
AB  - In this study, high electron mobility transistor (HEMT) device was used as an 
      immuno biosensor to measure concentration of a stress hormone, cortisol, by using 
      selective binding on cortisol monoclonal antibody (c-Mab). Also, the HEMT sensor 
      was enhanced in its sensitivity through light illumination to generate 
      photocurrent. The optical pumping could assist the biosensor to discriminate more 
      detailed change, which could result in an increment of limit of detection (LOD) 
      to 1.0 pM cortisol level. It was the lowest level of detection with semiconductor 
      device-based cortisol biosensors and the enhancement of surface potential 
      sensitivity was induced by laser light (532 nm). Output current amplificated by 
      photocurrent was higher than dark original current at about 3.39% when gate 
      voltage is applied with -3 V. Since the device could be applied to not only 
      standard cortisol solution but also real human salivary sample, it is expected to 
      apply for in vitro direct diagnosis of point-of-care test (POCT).
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Woo, Kyoungmin
AU  - Woo K
AD  - Department of Chemical Engineering, Myongji University, Yongin, 17058, Republic 
      of Korea.
FAU - Kang, Wonkyu
AU  - Kang W
AD  - Department of Chemical Engineering, Myongji University, Yongin, 17058, Republic 
      of Korea.
FAU - Lee, Kyungmin
AU  - Lee K
AD  - Department of Chemical Engineering, Myongji University, Yongin, 17058, Republic 
      of Korea.
FAU - Lee, Pilwoo
AU  - Lee P
AD  - Department of Chemical Engineering, Myongji University, Yongin, 17058, Republic 
      of Korea.
FAU - Kim, Yoonjae
AU  - Kim Y
AD  - Department of Chemical Engineering, Myongji University, Yongin, 17058, Republic 
      of Korea.
FAU - Yoon, Tae-Sik
AU  - Yoon TS
AD  - Department of Material Science and Engineering, Myongji University, Yongin, 
      17058, Republic of Korea.
FAU - Cho, Chu-Young
AU  - Cho CY
AD  - Korea Advanced Nano Fab Center (KANC), Suwon, 16229, Republic of Korea.
FAU - Park, Kyung-Ho
AU  - Park KH
AD  - Korea Advanced Nano Fab Center (KANC), Suwon, 16229, Republic of Korea.
FAU - Ha, Min-Woo
AU  - Ha MW
AD  - Department of Electrical Engineering, Myongji University, Yongin, 17058, Republic 
      of Korea. Electronic address: isobar@mju.ac.kr.
FAU - Lee, Hyun Ho
AU  - Lee HH
AD  - Department of Chemical Engineering, Myongji University, Yongin, 17058, Republic 
      of Korea. Electronic address: hyunho@mju.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20200412
PL  - England
TA  - Biosens Bioelectron
JT  - Biosensors & bioelectronics
JID - 9001289
RN  - 0 (Aluminum Compounds)
RN  - 0 (aluminum gallium nitride)
RN  - CH46OC8YV4 (Gallium)
RN  - VRA0C6810N (gallium nitrate)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - *Aluminum Compounds/chemistry
MH  - Biosensing Techniques/*instrumentation/*methods
MH  - *Gallium/chemistry
MH  - Humans
MH  - Hydrocortisone/*analysis
MH  - *Lasers
MH  - Microfluidic Analytical Techniques/methods
MH  - *Transistors, Electronic
OTO - NOTNLM
OT  - AlGaN/GaN
OT  - Biosensor
OT  - Cortisol
OT  - HEMT
OT  - Laser illumination
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/05/05 06:00
MHDA- 2021/02/09 06:00
CRDT- 2020/05/05 06:00
PHST- 2020/02/10 00:00 [received]
PHST- 2020/03/30 00:00 [revised]
PHST- 2020/04/01 00:00 [accepted]
PHST- 2020/05/05 06:00 [entrez]
PHST- 2020/05/05 06:00 [pubmed]
PHST- 2021/02/09 06:00 [medline]
AID - S0956-5663(20)30183-4 [pii]
AID - 10.1016/j.bios.2020.112186 [doi]
PST - ppublish
SO  - Biosens Bioelectron. 2020 Jul 1;159:112186. doi: 10.1016/j.bios.2020.112186. Epub 
      2020 Apr 12.