PMID- 32367427
OWN - NLM
STAT- MEDLINE
DCOM- 20210108
LR  - 20210108
IS  - 1573-6792 (Electronic)
IS  - 0896-0267 (Print)
IS  - 0896-0267 (Linking)
VI  - 33
IP  - 4
DP  - 2020 Jul
TI  - Spatiotemporal Dynamics of Single and Paired Pulse TMS-EEG Responses.
PG  - 425-437
LID - 10.1007/s10548-020-00773-6 [doi]
AB  - For physiological brain function a particular balance between excitation and 
      inhibition is essential. Paired pulse transcranial magnetic stimulation (TMS) can 
      estimate cortical excitability and the relative contribution of inhibitory and 
      excitatory networks. Combining TMS with electroencephalography (EEG) enables 
      additional assessment of the spatiotemporal dynamics of neuronal responses in the 
      stimulated brain. This study aims to evaluate the spatiotemporal dynamics and 
      stability of single and paired pulse TMS-EEG responses, and assess long 
      intracortical inhibition (LICI) at the cortical level. Twenty-five healthy 
      subjects were studied twice, approximately one week apart. Manual coil 
      positioning was applied in sixteen subjects and robot-guided positioning in nine. 
      Both motor cortices were stimulated with 50 single pulses and 50 paired pulses at 
      each of the five interstimulus intervals (ISIs): 100, 150, 200, 250 and 300 ms. 
      To assess stability and LICI, the intraclass correlation coefficient and 
      cluster-based permutation analysis were used. We found great resemblance in the 
      topographical distribution of the characteristic TMS-EEG components for single 
      and paired pulse TMS. Stimulation of the dominant and non-dominant hemisphere 
      resulted in a mirrored spatiotemporal dynamics. No significant effect on the 
      TMS-EEG responses was found for either stimulated hemisphere, time or coil 
      positioning method, indicating the stability of both single and paired pulse 
      TMS-EEG responses. For all ISIs, LICI was characterized by significant 
      suppression of the late N100 and P180 components in the central areas, without 
      affecting the early P30, N45 and P60 components. These observations in healthy 
      subjects can serve as reference values for future neuropsychiatric and 
      pharmacological studies.
FAU - de Goede, Annika A
AU  - de Goede AA
AUID- ORCID: 0000-0002-1549-6753
AD  - Department of Clinical Neurophysiology, Technical Medical Centre, University of 
      Twente, P.O. Box 217, Technohal 3385, 7500 AE, Enschede, The Netherlands. 
      a.a.degoede@utwente.nl.
FAU - Cumplido-Mayoral, Irene
AU  - Cumplido-Mayoral I
AD  - Department of Clinical Neurophysiology, Technical Medical Centre, University of 
      Twente, P.O. Box 217, Technohal 3385, 7500 AE, Enschede, The Netherlands.
AD  - Biomedical Engineering, Technical Medical Centre, University of Twente, Enschede, 
      The Netherlands.
FAU - van Putten, Michel J A M
AU  - van Putten MJAM
AD  - Department of Clinical Neurophysiology, Technical Medical Centre, University of 
      Twente, P.O. Box 217, Technohal 3385, 7500 AE, Enschede, The Netherlands.
AD  - Department of Neurology and Clinical Neurophysiology, Medisch Spectrum Twente, 
      Enschede, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200504
PL  - United States
TA  - Brain Topogr
JT  - Brain topography
JID - 8903034
SB  - IM
MH  - Adult
MH  - *Electroencephalography
MH  - Evoked Potentials, Motor
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Motor Cortex
MH  - Neural Inhibition
MH  - *Transcranial Magnetic Stimulation
MH  - Young Adult
PMC - PMC7293671
OTO - NOTNLM
OT  - Electroencephalography
OT  - Long intracortical inhibition
OT  - Spatiotemporal dynamics
OT  - Stability
OT  - TMS-EEG
OT  - Transcranial magnetic stimulation
COIS- Michel J.A.M. van Putten is co-founder of Clinical Science Systems, Leiden, the 
      Netherlands.
EDAT- 2020/05/06 06:00
MHDA- 2021/01/09 06:00
PMCR- 2020/05/04
CRDT- 2020/05/06 06:00
PHST- 2019/07/05 00:00 [received]
PHST- 2020/04/21 00:00 [accepted]
PHST- 2020/05/06 06:00 [pubmed]
PHST- 2021/01/09 06:00 [medline]
PHST- 2020/05/06 06:00 [entrez]
PHST- 2020/05/04 00:00 [pmc-release]
AID - 10.1007/s10548-020-00773-6 [pii]
AID - 773 [pii]
AID - 10.1007/s10548-020-00773-6 [doi]
PST - ppublish
SO  - Brain Topogr. 2020 Jul;33(4):425-437. doi: 10.1007/s10548-020-00773-6. Epub 2020 
      May 4.