PMID- 32368623
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220414
IS  - 2405-6308 (Electronic)
IS  - 2405-6308 (Linking)
VI  - 23
DP  - 2020 Jul
TI  - Long-term patient-reported distress in locally advanced cervical cancer patients 
      treated with definitive chemoradiation.
PG  - 1-8
LID - 10.1016/j.ctro.2020.04.005 [doi]
AB  - BACKGROUND AND PURPOSE: To evaluate longitudinal patient-reported distress in 
      cervical cancer patients treated with definitive chemoradiation (CRT). MATERIALS 
      AND METHODS: Between 2011 and 2016, consenting cervical cancer patients treated 
      with definitive CRT who completed >/= 2 revised Edmonton Symptom Assessment System 
      (ESAS-r) questionnaires at clinical visits, including baseline, were included. A 
      linear mixed model was used to assess the longitudinal trend in ESAS-r. A minimal 
      clinically important difference (MCID) for total ESAS-r score was defined as a 
      change of 3-points for improvement and 4-points for deterioration. The proportion 
      of patients with an MCID over time was described using moving averages. To test 
      for changes, mixed effects logistic models were fitted, each of which included 
      patient-specific random intercepts and random slopes. RESULTS: 67 patients were 
      eligible for analysis (736 ESAS-r assessments). Median (range) follow-up was 
      24 months (range: 15-45) and compliance at 12 months was 60% (40/67). There was a 
      significant decrease in ESAS-r scores over time. Baseline ESAS-r was strongly 
      predictive of ESAS-r at follow-up (p < 0.001). The proportion of patients with an 
      MCID for improvement from baseline significantly increased over time (p < 0.001) 
      and the proportion with an MCID for deterioration significantly decreased over 
      time (p < 0.001). No predictors for distress were found. CONCLUSIONS: Long-term 
      cervical cancer survivors experience distress that significantly improves over 
      time to an extent expected to be clinically meaningful for patients. Implementing 
      cervical cancer specific patient-reported outcome tools into practice could 
      better inform patient needs.
CI  - (c) 2020 Published by Elsevier B.V. on behalf of European Society for Radiotherapy 
      and Oncology.
FAU - Conway, Jessica L
AU  - Conway JL
AD  - Department of Radiation Oncology, University of Toronto, Ontario, Canada.
AD  - University Health Network, Princess Margaret Cancer Centre, Ontario, Canada.
FAU - Felder, Shira
AU  - Felder S
AD  - Department of Radiation Oncology, University of Toronto, Ontario, Canada.
AD  - University Health Network, Princess Margaret Cancer Centre, Ontario, Canada.
FAU - Tang, Jiayin
AU  - Tang J
AD  - Department of Radiation Oncology, University of Toronto, Ontario, Canada.
AD  - University Health Network, Princess Margaret Cancer Centre, Ontario, Canada.
FAU - Lukovic, Jelena
AU  - Lukovic J
AD  - Department of Radiation Oncology, University of Toronto, Ontario, Canada.
AD  - University Health Network, Princess Margaret Cancer Centre, Ontario, Canada.
FAU - Han, Kathy
AU  - Han K
AD  - Department of Radiation Oncology, University of Toronto, Ontario, Canada.
AD  - University Health Network, Princess Margaret Cancer Centre, Ontario, Canada.
FAU - Liu, Zhihui
AU  - Liu Z
AD  - University Health Network, Princess Margaret Cancer Centre, Ontario, Canada.
AD  - Dalla Lana School of Public Health, University of Toronto, Ontario, Canada.
FAU - Milosevic, Michael
AU  - Milosevic M
AD  - Department of Radiation Oncology, University of Toronto, Ontario, Canada.
AD  - University Health Network, Princess Margaret Cancer Centre, Ontario, Canada.
FAU - Fyles, Anthony
AU  - Fyles A
AD  - Department of Radiation Oncology, University of Toronto, Ontario, Canada.
AD  - University Health Network, Princess Margaret Cancer Centre, Ontario, Canada.
FAU - Croke, Jennifer
AU  - Croke J
AD  - Department of Radiation Oncology, University of Toronto, Ontario, Canada.
AD  - University Health Network, Princess Margaret Cancer Centre, Ontario, Canada.
LA  - eng
PT  - Journal Article
DEP - 20200416
PL  - Ireland
TA  - Clin Transl Radiat Oncol
JT  - Clinical and translational radiation oncology
JID - 101713416
PMC - PMC7186264
OTO - NOTNLM
OT  - Brachytherapy
OT  - Cervical cancer
OT  - Distress
OT  - Patient-reported outcomes
OT  - Survivorship
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2020/05/06 06:00
MHDA- 2020/05/06 06:01
PMCR- 2020/04/16
CRDT- 2020/05/06 06:00
PHST- 2019/06/11 00:00 [received]
PHST- 2020/04/10 00:00 [revised]
PHST- 2020/04/11 00:00 [accepted]
PHST- 2020/05/06 06:00 [entrez]
PHST- 2020/05/06 06:00 [pubmed]
PHST- 2020/05/06 06:01 [medline]
PHST- 2020/04/16 00:00 [pmc-release]
AID - S2405-6308(20)30029-X [pii]
AID - 10.1016/j.ctro.2020.04.005 [doi]
PST - epublish
SO  - Clin Transl Radiat Oncol. 2020 Apr 16;23:1-8. doi: 10.1016/j.ctro.2020.04.005. 
      eCollection 2020 Jul.