PMID- 32368686
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240328
IS  - 2451-8301 (Electronic)
IS  - 2451-8301 (Linking)
VI  - 8
DP  - 2020 Jun
TI  - Neuroprotective potential of solanesol in a combined model of intracerebral and 
      intraventricular hemorrhage in rats.
PG  - 101-114
LID - 10.1016/j.ibror.2020.03.001 [doi]
AB  - Intracerebral hemorrhage (ICH) may be caused by trauma, aneurysm and 
      arteriovenous malformation, as can any bleeding within the intracranial vault, 
      including brain parenchyma and adjacent meningeal spaces (aneurism and 
      atreovenous malformation). ICH is the cerebral stroke with the least treatable 
      form. Over time, intraventricular hemorrhage (IVH) is associated with ICH, which 
      contributes to hydrocephalus, and the major cause of most hemorrhagic death (Due 
      to the cerebral hemorrhage and post hemorrhagic surgeries). Most patients suffer 
      from memory impairment, grip strength, posture, and cognitive dysfunctions 
      attributable to cerebral hemorrhage or post-brain hemorrhagic surgery. 
      Nevertheless, a combined model of ICH based IVH is not present pre-clinically. 
      Autologous blood (ALB) injection (20 mul/5 min) in the rat brain triggers 
      hemorrhage, such as factors that further interfere with the normal functioning of 
      neuroinflammatory cytokines, oxidative stress, and neurotransmitter dysfunction, 
      such as CoQ10 insufficiency and dysregulation of mitochondrial ETC-complexes. For 
      the prevention of post-brain hemorrhagic behavioral and neurochemical 
      dysfunctions, there is no specific drug treatment available, only available 
      therapy used to provide symptomatic relief. The current study reveals that 
      long-term administration of Solanesol (SNL) 40 and 60 mg/kg alone and in 
      combination with available drug therapy Donepezil (DNP) 3 mg/kg, Memantine (MEM) 
      20 mg/kg, Celecoxib (CLB) 20 mg/kg, Pregabalin (PGB) 30 mg/kg, may provide the 
      neuroprotective effect by improving behavioral and neurochemical deficits, and 
      gross pathological changes in ALB induced combined experimental model of ICH-IVH 
      in post brain hemorrhagic conditions in rats. Thus, SNL can be a potential 
      therapeutic approach to improve neuronal mitochondrial dysfunction associated 
      with post brain hemorrhagic behavioral and neurochemical alterations.
CI  - (c) 2020 The Author(s).
FAU - Rajdev, Kajal
AU  - Rajdev K
AD  - Neuropharmacology Division, ISF College of Pharmacy, Moga, 142001 Punjab, India.
FAU - Siddiqui, Ehraz Mehmood
AU  - Siddiqui EM
AD  - Neuropharmacology Division, ISF College of Pharmacy, Moga, 142001 Punjab, India.
FAU - Jadaun, Kuldeep Singh
AU  - Jadaun KS
AD  - Neuropharmacology Division, ISF College of Pharmacy, Moga, 142001 Punjab, India.
FAU - Mehan, Sidharth
AU  - Mehan S
AD  - Neuropharmacology Division, ISF College of Pharmacy, Moga, 142001 Punjab, India.
LA  - eng
PT  - Journal Article
DEP - 20200422
PL  - England
TA  - IBRO Rep
JT  - IBRO reports
JID - 101691215
PMC - PMC7184235
OTO - NOTNLM
OT  - Celecoxib
OT  - Intracerebral-Intraventricular hemorrhage
OT  - Memantine
OT  - Mitochondrial dysfunction
OT  - Oxidative stress
OT  - Pregabalin
OT  - Solanesol
COIS- The authors have no conflict of interest to report.
EDAT- 2020/05/06 06:00
MHDA- 2020/05/06 06:01
PMCR- 2020/04/22
CRDT- 2020/05/06 06:00
PHST- 2019/07/17 00:00 [received]
PHST- 2020/03/13 00:00 [accepted]
PHST- 2020/05/06 06:00 [entrez]
PHST- 2020/05/06 06:00 [pubmed]
PHST- 2020/05/06 06:01 [medline]
PHST- 2020/04/22 00:00 [pmc-release]
AID - S2451-8301(20)30007-8 [pii]
AID - 10.1016/j.ibror.2020.03.001 [doi]
PST - epublish
SO  - IBRO Rep. 2020 Apr 22;8:101-114. doi: 10.1016/j.ibror.2020.03.001. eCollection 
      2020 Jun.