PMID- 32369679
OWN - NLM
STAT- MEDLINE
DCOM- 20210712
LR  - 20210712
IS  - 1756-5391 (Electronic)
IS  - 1756-5391 (Linking)
VI  - 13
IP  - 3
DP  - 2020 Aug
TI  - Vitamin D deficiency is not associated with graft versus host disease after 
      hematopoietic stem cell transplantation: A meta-analysis.
PG  - 183-191
LID - 10.1111/jebm.12383 [doi]
AB  - OBJECTIVE: Vitamin D status plays an important role in immunoregulation, and a 
      deficiency is believed to be related to Graft Versus Host Disease (GVHD) in 
      patients after hematopoietic stem cell transplantation (HSCT). We aim to study 
      the association between vitamin D deficiency and GVHD after HSCT. METHODS: A 
      literature search was conducted utilizing MEDLINE, EMBASE, and The Cochrane 
      Library Database from inception to July 2019. Eligible studies were required 
      to(1) be clinical trials or observational studies (cohort, case-control, or 
      cross-sectional studies);(2) provide data to calculate the odds ratios (OR) of 
      GVHD in HSCT patients with vitamin D deficiency. Two reviewers independently 
      extracted the data and assessed the risk of bias. Pooled odds ratios (OR) with 
      95% confidence interval (CI) were estimated using random-effects meta-analysis 
      through the Comprehensive Meta-Analysis 3.3 software. RESULTS: In total, 8 
      observational studies consisting of 1335 HSCT patients were enrolled in this 
      systematic review. Overall, there was no significant association between vitamin 
      D deficiency and acute GVHD (OR = 1.06, 95% CI 0.74-1.53, P > 0.05). There was no 
      significant association between vitamin D deficiency and chronic GVHD (OR = 1.75, 
      95% CI 0.72-4.26, P > 0.05). Funnel plots and Egger regression asymmetry test 
      were performed and showed no publication bias. CONCLUSION: There is not a 
      statistically significant association between vitamin D deficiency and neither 
      acute nor chronic GVHD.
CI  - (c) 2020 Chinese Cochrane Center, West China Hospital of Sichuan University and 
      John Wiley & Sons Australia, Ltd.
FAU - Chiengthong, Kanhatai
AU  - Chiengthong K
AD  - Division of Pediatric Hematology and Oncology, Department of Pediatrics, Faculty 
      of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, 
      Bangkok, Thailand.
AD  - King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
FAU - Cheungpasitporn, Wisit
AU  - Cheungpasitporn W
AD  - Department of Medicine, University of Mississippi Medical Center, Mississippi, 
      Jackson.
FAU - Thongprayoon, Charat
AU  - Thongprayoon C
AD  - Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
FAU - Lertjitbanjong, Ploypin
AU  - Lertjitbanjong P
AD  - Department of Internal Medicine, Bassett Medical Center, Cooperstown, New York.
FAU - Cato, Liam D
AU  - Cato LD
AD  - University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
FAU - Bathini, Tarun
AU  - Bathini T
AD  - Department of Internal Medicine, University of Arizona, Tucson, Arizona.
FAU - Ungprasert, Patompong
AU  - Ungprasert P
AD  - Clinical Epidemiology Unit, Department of Research and Development, Faculty of 
      Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
FAU - Mao, Michael A
AU  - Mao MA
AD  - Department of Internal Medicine, Mayo Clinic, Jacksonville, Florida.
FAU - Chokesuwattanaskul, Ronpichai
AU  - Chokesuwattanaskul R
AD  - King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
AD  - Division of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, 
      Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, 
      Thailand.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20200505
PL  - England
TA  - J Evid Based Med
JT  - Journal of evidence-based medicine
JID - 101497477
SB  - IM
MH  - Graft vs Host Disease/*etiology
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Humans
MH  - Vitamin D Deficiency/*complications
OTO - NOTNLM
OT  - graft versus host disease (GVHD)
OT  - hematopoietic stem cell transplantation (HSCT)
OT  - vitamin D
OT  - vitamin D deficiency
EDAT- 2020/05/06 06:00
MHDA- 2021/07/13 06:00
CRDT- 2020/05/06 06:00
PHST- 2020/01/28 00:00 [received]
PHST- 2020/03/04 00:00 [accepted]
PHST- 2020/05/06 06:00 [pubmed]
PHST- 2021/07/13 06:00 [medline]
PHST- 2020/05/06 06:00 [entrez]
AID - 10.1111/jebm.12383 [doi]
PST - ppublish
SO  - J Evid Based Med. 2020 Aug;13(3):183-191. doi: 10.1111/jebm.12383. Epub 2020 May 
      5.