PMID- 32371243
OWN - NLM
STAT- MEDLINE
DCOM- 20200925
LR  - 20200925
IS  - 1534-4436 (Electronic)
IS  - 1081-1206 (Linking)
VI  - 125
IP  - 3
DP  - 2020 Sep
TI  - Association of IL13 genetic polymorphisms with atopic dermatitis: Fine mapping 
      and haplotype analysis.
PG  - 287-293
LID - S1081-1206(20)30271-4 [pii]
LID - 10.1016/j.anai.2020.04.023 [doi]
AB  - BACKGROUND: Although previous studies had reported an important role of 
      interleukin 13 (IL13) and its genetic polymorphisms in atopic dermatitis (AD), 
      many of these previous reports focused on the missense variant rs20541 
      (Gln144Arg) without fine mapping of the gene region. OBJECTIVE: To analyze the 
      potential associations of other IL13 variants and their haplotypes with AD and 
      assess total serum immunoglobulin E (IgE) levels. METHODS: We performed fine 
      mapping of single-nucleotide polymorphisms (SNPs) within the IL13 gene in a pilot 
      study of 495 children with AD and 444 healthy controls. Then, we conducted a 
      replication study of 757 children with AD and 1620 healthy controls to evaluate 
      the association between the rs20541 variant of IL13 and AD. RESULTS: In the pilot 
      study, the rs20541 and rs1295685 SNPs in the 3'-untranslated region of IL13 had 
      significant associations with AD (P < .001 and .01, respectively). In addition, 2 
      haplotypes (BL2_ht1 and BL2_ht2), which harbored the significant rs20541 and 
      rs1295685 SNPs, had an association with AD (minimum P = .006). BL2_ht1 and 
      BL2_ht2 had nominal signals associated with the total serum IgE levels (P < .05) 
      but not with the severity of AD (P > .05). In the replication study, rs20541 was 
      associated with the total serum IgE levels but not with the severity of AD. 
      CONCLUSION: An additional IL13 gene SNP, rs1295685, has a strong linkage 
      disequilibrium with rs20541, and its haplotypes are associated with AD and the 
      total serum IgE levels.
CI  - Copyright (c) 2020 American College of Allergy, Asthma & Immunology. Published by 
      Elsevier Inc. All rights reserved.
FAU - Lee, Eun
AU  - Lee E
AD  - Department of Pediatrics, Chonnam National University Hospital, Chonnam National 
      University Medical School, Gwangju, Republic of Korea.
FAU - Kim, Jeong-Hyun
AU  - Kim JH
AD  - Department of Medicine, University of Ulsan College of Medicine, Seoul, Republic 
      of Korea.
FAU - Lee, So-Yeon
AU  - Lee SY
AD  - Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health 
      Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 
      Republic of Korea.
FAU - Kang, Mi-Jin
AU  - Kang MJ
AD  - Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, 
      Republic of Korea.
FAU - Park, Yoon Mee
AU  - Park YM
AD  - Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, 
      Republic of Korea.
FAU - Park, Min Jee
AU  - Park MJ
AD  - Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health 
      Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 
      Republic of Korea.
FAU - Rhee, Eun-Sang
AU  - Rhee ES
AD  - Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health 
      Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 
      Republic of Korea.
FAU - Ahn, Kangmo
AU  - Ahn K
AD  - Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Environmental Health Center for Atopic Diseases, Seoul, Republic of 
      Korea.
FAU - Kim, Kyung Won
AU  - Kim KW
AD  - Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic 
      of Korea.
FAU - Shin, Youn Ho
AU  - Shin YH
AD  - Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of 
      Medicine, Seoul, Republic of Korea.
FAU - Suh, Dong In
AU  - Suh DI
AD  - Department of Pediatrics, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Hong, Soo-Jong
AU  - Hong SJ
AD  - Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health 
      Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 
      Republic of Korea. Electronic address: sjhong@amc.seoul.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200501
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American 
      College of Allergy, Asthma, & Immunology
JID - 9503580
RN  - 0 (Interleukin-13)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Case-Control Studies
MH  - Child
MH  - Dermatitis, Atopic/blood/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Haplotypes/*genetics
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Interleukin-13/*genetics
MH  - Male
MH  - Pilot Projects
MH  - Polymorphism, Single Nucleotide/*genetics
EDAT- 2020/05/07 06:00
MHDA- 2020/09/26 06:00
CRDT- 2020/05/07 06:00
PHST- 2020/03/05 00:00 [received]
PHST- 2020/04/16 00:00 [revised]
PHST- 2020/04/22 00:00 [accepted]
PHST- 2020/05/07 06:00 [pubmed]
PHST- 2020/09/26 06:00 [medline]
PHST- 2020/05/07 06:00 [entrez]
AID - S1081-1206(20)30271-4 [pii]
AID - 10.1016/j.anai.2020.04.023 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2020 Sep;125(3):287-293. doi: 
      10.1016/j.anai.2020.04.023. Epub 2020 May 1.