PMID- 32372062
OWN - NLM
STAT- MEDLINE
DCOM- 20201009
LR  - 20210313
IS  - 1759-507X (Electronic)
IS  - 1759-5061 (Linking)
VI  - 16
IP  - 7
DP  - 2020 Jul
TI  - Kidney dendritic cells: fundamental biology and functional roles in health and 
      disease.
PG  - 391-407
LID - 10.1038/s41581-020-0272-y [doi]
AB  - Dendritic cells (DCs) are chief inducers of adaptive immunity and regulate local 
      inflammatory responses across the body. Together with macrophages, the other main 
      type of mononuclear phagocyte, DCs constitute the most abundant component of the 
      intrarenal immune system. This network of functionally specialized immune cells 
      constantly surveys its microenvironment for signs of injury or infection, which 
      trigger the initiation of an immune response. In the healthy kidney, DCs 
      coordinate effective immune responses, for example, by recruiting neutrophils for 
      bacterial clearance in pyelonephritis. The pro-inflammatory actions of DCs can, 
      however, also contribute to tissue damage in various types of acute kidney injury 
      and chronic glomerulonephritis, as DCs recruit and activate effector T cells, 
      which release toxic mediators and maintain tubulointerstitial immune infiltrates. 
      These actions are counterbalanced by DC subsets that promote the activation and 
      maintenance of regulatory T cells to support resolution of the immune response 
      and allow kidney repair. Several studies have investigated the multiple roles for 
      DCs in kidney homeostasis and disease, but it has become clear that current tools 
      and subset markers are not sufficient to accurately distinguish DCs from 
      macrophages. Multidimensional transcriptomic analysis studies promise to improve 
      mononuclear phagocyte classification and provide a clearer view of DC ontogeny 
      and subsets.
FAU - Kurts, Christian
AU  - Kurts C
AUID- ORCID: 0000-0002-6620-2401
AD  - Institute of Experimental Immunology, Rheinische Friedrich-Wilhelms-Universitat, 
      Venusbergcampus, Bonn, Germany. ckurts@web.de.
FAU - Ginhoux, Florent
AU  - Ginhoux F
AUID- ORCID: 0000-0002-2857-7755
AD  - Singapore Immunology Network (SIgN), Agency for Science Technology and Research 
      (A*STAR), Singapore, Singapore.
AD  - Shanghai Institute of Immunology, Shanghai JiaoTong University School of 
      Medicine, Shanghai, China.
AD  - Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre, 
      Singapore, Singapore.
FAU - Panzer, Ulf
AU  - Panzer U
AD  - Division of Translational Immunology, III Medizinische Klinik, 
      Universitatsklinikum Hamburg-Eppendorf, Hamburg, Germany.
AD  - Hamburg Center of Translational Immunology, Universitatsklinikum 
      Hamburg-Eppendorf, Hamburg, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200505
PL  - England
TA  - Nat Rev Nephrol
JT  - Nature reviews. Nephrology
JID - 101500081
SB  - IM
MH  - Acute Kidney Injury/*immunology
MH  - Dendritic Cells/cytology/*immunology/metabolism
MH  - Gene Expression Profiling
MH  - Glomerulonephritis/*immunology
MH  - Humans
MH  - Inflammation/*immunology
MH  - Kidney/cytology/*immunology
MH  - Lymphocyte Activation/immunology
MH  - Macrophages/immunology
MH  - Neutrophils/immunology
MH  - Pyelonephritis/immunology
MH  - T-Lymphocytes/immunology
MH  - T-Lymphocytes, Regulatory/immunology
EDAT- 2020/05/07 06:00
MHDA- 2020/10/10 06:00
CRDT- 2020/05/07 06:00
PHST- 2020/03/18 00:00 [accepted]
PHST- 2020/05/07 06:00 [pubmed]
PHST- 2020/10/10 06:00 [medline]
PHST- 2020/05/07 06:00 [entrez]
AID - 10.1038/s41581-020-0272-y [pii]
AID - 10.1038/s41581-020-0272-y [doi]
PST - ppublish
SO  - Nat Rev Nephrol. 2020 Jul;16(7):391-407. doi: 10.1038/s41581-020-0272-y. Epub 
      2020 May 5.