PMID- 32372315
OWN - NLM
STAT- MEDLINE
DCOM- 20210208
LR  - 20210208
IS  - 2589-0409 (Electronic)
IS  - 1110-0362 (Linking)
VI  - 32
IP  - 1
DP  - 2020 Jan 30
TI  - Unmasking lymphoma immune reconstitution inflammatory syndrome in a patient with 
      pyrexia of unknown origin: a case report.
PG  - 8
LID - 10.1186/s43046-020-0019-7 [doi]
AB  - BACKGROUND: Immune reconstitution inflammatory syndrome (IRIS) is a constellation 
      of inflammatory disorders that are unmasked after the initiation of 
      anti-retroviral therapy (ART) in Human immunodeficiency virus (HIV) infected 
      patients. Unmasking lymphoma IRIS is a relatively rare manifestation after 
      initiation of anti-retroviral therapy. CASE PRESENTATION: We report a 44-year-old 
      male with HIV on 4 months of ART presenting with pyrexia of unknown origin with a 
      diagnosis of unmasking Hodgkin's lymphoma IRIS stage IV with B symptoms. This 
      case portrays the importance of recognizing the possibility of Hodgkin's lymphoma 
      as a possible manifestation of IRIS within the first 6 months of initiation of 
      ART. CONCLUSION: Patients presenting with pyrexia of unknown origin and 
      lymphadenopathy within the first 6 months of initiation of ART, lymphoma 
      diagnosis should be on the high threshold of suspicion as portrayed by our case.
FAU - Mahajan, Mansi
AU  - Mahajan M
AD  - School of Medicine, Wayne State University, Detroit, MI, USA.
FAU - Venkatesulu, Bhanu Prasad
AU  - Venkatesulu BP
AUID- ORCID: 0000-0003-2541-2055
AD  - Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA. 
      bpmmc24@gmail.com.
FAU - Sallam, Omar
AU  - Sallam O
AD  - Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.
FAU - Taneja, Kanika
AU  - Taneja K
AD  - Department of Pathology, Henry Ford Hospital, Detroit, MI, USA.
FAU - Scott, Megan
AU  - Scott M
AD  - Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.
FAU - Brar, Indira
AU  - Brar I
AD  - Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20200130
PL  - England
TA  - J Egypt Natl Canc Inst
JT  - Journal of the Egyptian National Cancer Institute
JID - 9424566
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Adult
MH  - Anti-HIV Agents/*therapeutic use
MH  - Diagnosis, Differential
MH  - Fever/*diagnosis/immunology
MH  - HIV Infections/complications/*drug therapy/immunology
MH  - Hodgkin Disease/*diagnosis/immunology/pathology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*diagnosis/immunology
MH  - Lymph Nodes/pathology
MH  - Male
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - HIV
OT  - IRIS
OT  - Lymphoma
OT  - PUO
EDAT- 2020/05/07 06:00
MHDA- 2021/02/09 06:00
CRDT- 2020/05/07 06:00
PHST- 2019/10/10 00:00 [received]
PHST- 2020/01/20 00:00 [accepted]
PHST- 2020/05/07 06:00 [entrez]
PHST- 2020/05/07 06:00 [pubmed]
PHST- 2021/02/09 06:00 [medline]
AID - 10.1186/s43046-020-0019-7 [pii]
AID - 10.1186/s43046-020-0019-7 [doi]
PST - epublish
SO  - J Egypt Natl Canc Inst. 2020 Jan 30;32(1):8. doi: 10.1186/s43046-020-0019-7.