PMID- 32372954
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220414
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 11
DP  - 2020
TI  - Pain Following the Use of Anesthesia Formulation Among Individuals Undergoing 
      Cataract Surgery: A Randomized Controlled Trial.
PG  - 440
LID - 10.3389/fphar.2020.00440 [doi]
LID - 440
AB  - PURPOSE: To assess the pain intensity of two intracameral anesthetic solutions in 
      patients undergoing cataract surgery and evaluate the factors influencing the 
      patients' postoperative activities. METHODS: Sixty-two patients undergoing 
      cataract surgery were randomized to receive the study drug - a manufactured 
      solution of 0.02% tropicamide/0.31% phenylephrine/1% lidocaine (Mydrane) or a 
      traditional anesthetic formulation - solution of 1% lidocaine/0.025% adrenaline 
      as an intraocular anesthetic. The pain intensity was assessed by Visual Analog 
      Scale for Pain (VAS Pain) and Brief Pain Inventory-short form (BPI) on the next 
      day after the surgery. RESULTS: The mean pain score measured preoperatively with 
      VAS Pain was 0.34 in Mydrane group and 0.09 in the reference group (p = 0.51). 
      There were no statistically significant differences between the two anesthetic 
      methods with respect to pain intensity during the surgery (p = 0.94) and the 
      influence of pain during the last 24 h on activity (p = 0.79), mood (p = 0.31), 
      social contacts (p = 0.29), sleep (p = 0.5) and the joy of life (p = 0.39). 
      Additionally, there was no statistically significant influence of age, sex, 
      lateralization, co-existing ophthalmological diseases (p = 0.98) and 
      post-operative complications (p = 0.4) on the experienced pain measured during 
      the surgery and in the last 24 h. CONCLUSIONS: New commercially available 
      intraocular anesthetic solution (Mydrane) seems to be as effective as off-label 
      traditional anesthetic formulation, in reducing the pain experienced during 
      cataract surgery under topical anesthesia.
CI  - Copyright (c) 2020 Toro, Nowakowska, Brzozowska, Reibaldi, Avitabile, Bucolo, 
      Murabito, Chisari, Nowomiejska and Rejdak.
FAU - Toro, Mario D
AU  - Toro MD
AD  - Department of General Ophthalmology, Medical University of Lublin, Lublin, 
      Poland.
AD  - Faculty of Medicine, Collegium Medicum, Cardinal Stefan Wyszynski University, 
      Warsaw, Poland.
FAU - Nowakowska, Dominika
AU  - Nowakowska D
AD  - Department of General Ophthalmology, Medical University of Lublin, Lublin, 
      Poland.
FAU - Brzozowska, Agnieszka
AU  - Brzozowska A
AD  - Department of Mathematics and Medical Biostatistics, Medical University of 
      Lublin, Lublin, Poland.
FAU - Reibaldi, Michele
AU  - Reibaldi M
AD  - Department of Ophthalmology, School of Medicine, University of Catania, Catania, 
      Italy.
FAU - Avitabile, Teresio
AU  - Avitabile T
AD  - Department of Ophthalmology, School of Medicine, University of Catania, Catania, 
      Italy.
FAU - Bucolo, Claudio
AU  - Bucolo C
AD  - Department of Biomedical and Biotechnological Sciences, School of Medicine, 
      University of Catania, Catania, Italy.
FAU - Murabito, Paolo
AU  - Murabito P
AD  - Department of General Surgery and Surgical Specialties, Division of 
      Anesthesiology, Azienda Ospedaliero-Universitaria Policlinico, Catania, Italy.
FAU - Chisari, Clara
AU  - Chisari C
AD  - Department "GF. Ingrassia", Section of Neurosciences, University of Catania, 
      Catania, Italy.
FAU - Nowomiejska, Katarzyna
AU  - Nowomiejska K
AD  - Department of General Ophthalmology, Medical University of Lublin, Lublin, 
      Poland.
FAU - Rejdak, Robert
AU  - Rejdak R
AD  - Department of General Ophthalmology, Medical University of Lublin, Lublin, 
      Poland.
LA  - eng
PT  - Journal Article
DEP - 20200416
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC7176993
OTO - NOTNLM
OT  - cataract surgery
OT  - intraocular anesthesia
OT  - lidocaine
OT  - ophthalmologic anesthesia
OT  - pain
OT  - phenylephrine
OT  - tropicamide
EDAT- 2020/05/07 06:00
MHDA- 2020/05/07 06:01
PMCR- 2020/04/16
CRDT- 2020/05/07 06:00
PHST- 2019/11/24 00:00 [received]
PHST- 2020/03/20 00:00 [accepted]
PHST- 2020/05/07 06:00 [entrez]
PHST- 2020/05/07 06:00 [pubmed]
PHST- 2020/05/07 06:01 [medline]
PHST- 2020/04/16 00:00 [pmc-release]
AID - 10.3389/fphar.2020.00440 [doi]
PST - epublish
SO  - Front Pharmacol. 2020 Apr 16;11:440. doi: 10.3389/fphar.2020.00440. eCollection 
      2020.