PMID- 32373969
OWN - NLM
STAT- MEDLINE
DCOM- 20210329
LR  - 20210329
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 24
IP  - 8
DP  - 2020 Apr
TI  - Circ_0067934 correlates with poor prognosis and promotes laryngeal squamous cell 
      cancer progression by sponging miR-1324.
PG  - 4320-4327
LID - 21013 [pii]
LID - 10.26355/eurrev_202004_21013 [doi]
AB  - OBJECTIVE: As a kind of non-coding RNA, circular RNA (circRNA) plays a regulatory 
      role in many tumors. Our intention was to investigate the clinical significance, 
      biological function, and molecular regulation mechanisms of circ_0067934 in 
      laryngeal squamous cell cancer (LSCC) progression. PATIENTS AND METHODS: The 
      expression levels of circ_0067934 in LSCC tumor samples and cells were determined 
      by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). The associations 
      of circ_0067934 expression with clinicopathological features and overall survival 
      in LSCC patients were statistically analyzed. The biological function of 
      circ_0067934 in LSCC cells was analyzed by CCK-8, colony formation, EdU, and 
      transwell assays. Dual-Luciferase reporter assay was conducted to verify that 
      circ_0067934 may sponge miR-1324 to regulate proliferation and migration of LSCC. 
      RESULTS: Circ_0067934 expression was remarkably upregulated in LSCC tissues and 
      cells. High level of circ_0067934 was significantly related to tumor size, lymph 
      node status, and distant metastasis of LSCC. Furthermore, highly expressed 
      circ_0067934 could result in notably worse survival. In vitro experiments showed 
      that down-regulation of circ_0067934 inhibited proliferation and migration of 
      LSCC cells. Mechanism analysis revealed that circ_0067934 regulated LSCC 
      development by sponging miR-1324. CONCLUSIONS: Circ_0067934 may function as an 
      oncogene in LSCC, which provided a feasible prognostic biomarker and therapeutic 
      target for LSCC.
FAU - Chu, Y-L
AU  - Chu YL
AD  - Department of Otorhinolaryngology, Air Force Hospital of the Northern Theater of 
      the People's Liberation Army, Shenyang, China. 283598876@qq.com.
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (MIRN1324 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Circular)
SB  - IM
MH  - Carcinoma, Squamous Cell/diagnosis/*genetics/*pathology
MH  - Cell Movement
MH  - Cell Proliferation
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/diagnosis/*genetics/*pathology
MH  - Male
MH  - MicroRNAs/*genetics/metabolism
MH  - Middle Aged
MH  - Prognosis
MH  - RNA, Circular/genetics/*metabolism
EDAT- 2020/05/07 06:00
MHDA- 2021/03/30 06:00
CRDT- 2020/05/07 06:00
PHST- 2020/05/07 06:00 [entrez]
PHST- 2020/05/07 06:00 [pubmed]
PHST- 2021/03/30 06:00 [medline]
AID - 21013 [pii]
AID - 10.26355/eurrev_202004_21013 [doi]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2020 Apr;24(8):4320-4327. doi: 
      10.26355/eurrev_202004_21013.