PMID- 32375918
OWN - NLM
STAT- MEDLINE
DCOM- 20220124
LR  - 20220124
IS  - 1469-8978 (Electronic)
IS  - 0033-2917 (Linking)
VI  - 51
IP  - 14
DP  - 2021 Oct
TI  - Changes in visual memory in mild cognitive impairment: a longitudinal study with 
      CANTAB.
PG  - 2465-2475
LID - 10.1017/S0033291720001142 [doi]
AB  - BACKGROUND: Mild cognitive impairment (MCI), as a stage in the cognitive 
      continuum between normal ageing and dementia, is mainly characterized by memory 
      impairment. The aims of this study were to examine CANTAB measures of temporal 
      changes of visual memory in MCI and to evaluate the usefulness of the baseline 
      scores for predicting changes in cognitive status. METHODS: The study included 
      201 participants aged over 50 years with subjective cognitive complaints. Visual 
      memory was assessed with four CANTAB tests [paired associates learning (PAL), 
      delayed matching to sample (DMS), pattern recognition memory (PRM) and spatial 
      span (SSP)] administered at baseline and on two further occasions, with a 
      follow-up interval of 18-24 months. Participants were divided into three groups 
      according to the change in their cognitive status: participants with subjective 
      cognitive complaints who remained stable, MCI participants who remained stable 
      (MCI-Stable) and MCI participants whose cognitive deterioration continued 
      (MCI-Worsened). Linear mixed models were used to model longitudinal changes, with 
      evaluation time as a fixed variable, and multinomial regression models were used 
      to predict changes in cognitive status. RESULTS: Isolated significant effects 
      were obtained for age and group with all CANTAB tests used. Interactions between 
      evaluation time and group were identified in the PAL and DMS tests, indicating 
      different temporal patterns depending on the changes in cognitive status. 
      Regression models also indicated that CANTAB scores were good predictors of 
      changes in cognitive status. CONCLUSIONS: Decline in visual memory measured by 
      PAL and DMS tests can successfully distinguish different types of MCI, and 
      considered together PAL, DMS, PRM and SSP can predict changes in cognitive 
      status.
FAU - Campos-Magdaleno, Maria
AU  - Campos-Magdaleno M
AUID- ORCID: 0000-0002-1785-0736
AD  - Department of Developmental Psychology, University of Santiago de Compostela, 
      Galicia, Spain.
FAU - Leiva, David
AU  - Leiva D
AD  - Department of Methodology of Behavioural Sciences, University of Barcelona, 
      Catalunya, Spain.
FAU - Pereiro, Arturo X
AU  - Pereiro AX
AUID- ORCID: 0000-0002-7842-5565
AD  - Department of Developmental Psychology, University of Santiago de Compostela, 
      Galicia, Spain.
FAU - Lojo-Seoane, Cristina
AU  - Lojo-Seoane C
AUID- ORCID: 0000-0002-1034-972X
AD  - Department of Developmental Psychology, University of Santiago de Compostela, 
      Galicia, Spain.
FAU - Mallo, Sabela C
AU  - Mallo SC
AUID- ORCID: 0000-0001-5750-2608
AD  - Department of Developmental Psychology, University of Santiago de Compostela, 
      Galicia, Spain.
FAU - Facal, David
AU  - Facal D
AUID- ORCID: 0000-0001-6230-0090
AD  - Department of Developmental Psychology, University of Santiago de Compostela, 
      Galicia, Spain.
FAU - Juncos-Rabadan, Onesimo
AU  - Juncos-Rabadan O
AUID- ORCID: 0000-0002-2485-1171
AD  - Department of Developmental Psychology, University of Santiago de Compostela, 
      Galicia, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200507
PL  - England
TA  - Psychol Med
JT  - Psychological medicine
JID - 1254142
SB  - IM
MH  - Aged
MH  - Aging/physiology
MH  - Cognitive Dysfunction/*diagnosis
MH  - Humans
MH  - Longitudinal Studies
MH  - Memory Disorders/*diagnosis
MH  - Middle Aged
MH  - Neuropsychological Tests/*statistics & numerical data
MH  - Pattern Recognition, Visual/physiology
OTO - NOTNLM
OT  - CANTAB tests
OT  - linear mixed models
OT  - longitudinal assessment
OT  - mild cognitive impairment
OT  - visual memory
EDAT- 2020/05/08 06:00
MHDA- 2022/01/27 06:00
CRDT- 2020/05/08 06:00
PHST- 2020/05/08 06:00 [pubmed]
PHST- 2022/01/27 06:00 [medline]
PHST- 2020/05/08 06:00 [entrez]
AID - S0033291720001142 [pii]
AID - 10.1017/S0033291720001142 [doi]
PST - ppublish
SO  - Psychol Med. 2021 Oct;51(14):2465-2475. doi: 10.1017/S0033291720001142. Epub 2020 
      May 7.