PMID- 32376503
OWN - NLM
STAT- MEDLINE
DCOM- 20210129
LR  - 20210129
IS  - 1521-7035 (Electronic)
IS  - 1521-6616 (Linking)
VI  - 215
DP  - 2020 Jun
TI  - Circulating dendritic cells are severely decreased in idiopathic pulmonary 
      fibrosis with a potential value for prognosis prediction.
PG  - 108454
LID - S1521-6616(19)30676-X [pii]
LID - 10.1016/j.clim.2020.108454 [doi]
AB  - Dendritic cells (DCs) accumulate in the lung of patients affected by idiopathic 
      pulmonary fibrosis (IPF). We measured the frequencies of circulating conventional 
      CD1c + and CD141+ cells (namely, cDC2 and cDC1) and of plasmacytoid CD303+ DCs in 
      a cohort of 60 therapy naive IPF patients by flow cytometry. Peripheral levels of 
      reactive oxygen species (ROS) and of pro-inflammatory and Th1/Th2 polarizing 
      cytokines were also analyzed. All blood DC subtypes were significantly reduced in 
      IPF patients in comparison to age- and sex-matched controls, while ROS and 
      interleukin (IL-6) levels were augmented. IL-6 expression increased along with 
      disease severity, according to the gender-age-physiology index, and correlated 
      with the frequency of cDC2. IL-6 and cDC2 were not influenced by anti-fibrotic 
      therapies but were associated with a reduced survival, the latter being an 
      independent predictive biomarker of worse prognosis. Deciphering the role of DCs 
      in IPF might provide information on disease pathogenesis and clinical behavior.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Galati, Domenico
AU  - Galati D
AD  - Haematology-Oncology and Stem Cell Transplantation Unit, Department of 
      Haematology and Innovative Therapies, Istituto Nazionale Tumori- IRCCS- 
      Fondazione G. Pascale, Napoli, Italy. Electronic address: 
      d.galati@istitutotumori.na.it.
FAU - Zanotta, Serena
AU  - Zanotta S
AD  - Haematology-Oncology and Stem Cell Transplantation Unit, Department of 
      Haematology and Innovative Therapies, Istituto Nazionale Tumori- IRCCS- 
      Fondazione G. Pascale, Napoli, Italy.
FAU - Polistina, Giorgio Emanuele
AU  - Polistina GE
AD  - Respiratory Medicine Division, Department of Clinical Medicine and Surgery, 
      Federico II University, Napoli, Italy.
FAU - Coppola, Antonietta
AU  - Coppola A
AD  - Respiratory Medicine Division, Department of Clinical Medicine and Surgery, 
      Federico II University, Napoli, Italy.
FAU - Capitelli, Ludovica
AU  - Capitelli L
AD  - Respiratory Medicine Division, Department of Clinical Medicine and Surgery, 
      Federico II University, Napoli, Italy.
FAU - Bocchino, Marialuisa
AU  - Bocchino M
AD  - Respiratory Medicine Division, Department of Clinical Medicine and Surgery, 
      Federico II University, Napoli, Italy. Electronic address: 
      marialuisa.bocchino@unina.it.
LA  - eng
PT  - Journal Article
DEP - 20200505
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
SB  - IM
MH  - Aged
MH  - Biomarkers/metabolism
MH  - Cytokines/metabolism
MH  - Dendritic Cells/*metabolism/*pathology
MH  - Female
MH  - Humans
MH  - Idiopathic Pulmonary Fibrosis/*metabolism/*pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
OTO - NOTNLM
OT  - Dendritic cells
OT  - Flow cytometry
OT  - Idiopathic pulmonary fibrosis
OT  - Interleukin-6
OT  - Oxidative burst
COIS- Declaration of Competing Interest All authors declare they have no conflicting 
      interests for this study.
EDAT- 2020/05/08 06:00
MHDA- 2021/01/30 06:00
CRDT- 2020/05/08 06:00
PHST- 2019/12/06 00:00 [received]
PHST- 2020/04/15 00:00 [revised]
PHST- 2020/04/29 00:00 [accepted]
PHST- 2020/05/08 06:00 [pubmed]
PHST- 2021/01/30 06:00 [medline]
PHST- 2020/05/08 06:00 [entrez]
AID - S1521-6616(19)30676-X [pii]
AID - 10.1016/j.clim.2020.108454 [doi]
PST - ppublish
SO  - Clin Immunol. 2020 Jun;215:108454. doi: 10.1016/j.clim.2020.108454. Epub 2020 May 
      5.