PMID- 32377250
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220414
IS  - 1841-0987 (Print)
IS  - 1843-066X (Electronic)
IS  - 1841-0987 (Linking)
VI  - 15
IP  - 4
DP  - 2019 Oct-Dec
TI  - ADRENAL INCIDENTALOMA, BREAST CANCER AND UNRECOGNIZED MULTIPLE ENDOCRINE 
      NEOPLASIA TYPE 1.
PG  - 513-517
LID - 10.4183/aeb.2019.513 [doi]
AB  - BACKGROUND: The incidence of adrenal incidentaloma has been increasing 
      proportional to the use of radiologic examination. Multiple endocrine neoplasia1 
      (MEN1) syndrome may present with various tumors. The present study reports a case 
      of adrenal incidentaloma with unrecognised MEN1 syndrome associated with breast 
      cancer. CLINICAL CASE: A 48-year-old woman presented with a 2.4cm left adrenal 
      incidentaloma on abdominal computed tomography. Her history revealed primary 
      amenorrhea, recurrent peptic ulcer and nephrolithiasis. Laboratory and radiologic 
      examination revealed two pancreatic tail mass lesions with markedly elevated 
      gastrin levels (1462 pg/mL), hypercalcemia with increased parathyroid hormone 
      levels (72 pg/mL), a 1.5cm pituitary mass with hyperprolactinemia (234 ng/mL), a 
      1.0cm meningioma and a nonfunctional left adrenal mass. During this image work 
      up, a 0.6cm nodule in the right breast was incidentally detected. Surgeries 
      (laparoscopic distal pancreatectomy, parathyroidectomy and wide local excision of 
      breast) and pathologic findings confirmed pancreatic neuroendocrine tumors, 
      parathyroid gland hyperplasia, and breast cancer. Carbergoline treatment for 12 
      months decreased prolactin levels to 27 ng/mL. Genetic testing using peripheral 
      blood revealed a pathogenic variant in MEN1 on chr11q13 
      (NM_000244.3:c.1365+1_1365+11 del, GTGAGGGACAG, heterozygous). CONCLUSION: 
      Considering the increasing incidence of adrenal incidentaloma and 20% prevalence 
      of adrenal tumors in patients with MEN1, it is important to rule out MEN1 
      association in patients with adrenal incidentaloma. Additionally, breast cancer 
      was detected during MEN1 work-up in this case. Female patients with MEN1 are at 
      increased risk for breast cancer. Therefore, intensified breast cancer screening 
      at a relatively young age should be considered in female MEN1 patients.
CI  - (c)by Acta Endocrinologica Foundation.
FAU - Kim, S H
AU  - Kim SH
AD  - Presbyterian Medical Center - Department of Internal Medicine, Jeonju, Republic 
      of Korea.
FAU - Park, J H
AU  - Park JH
AD  - Jeonbuk National University Medical School - Department of Internal Medicine, 
      Jeonju, Republic of Korea.
LA  - eng
PT  - Case Reports
PL  - Romania
TA  - Acta Endocrinol (Buchar)
JT  - Acta endocrinologica (Bucharest, Romania : 2005)
JID - 101269720
PMC - PMC7200108
OTO - NOTNLM
OT  - Adrenal incidentaloma
OT  - Breast cancer
OT  - Multiple endocrine neoplasia 1
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/05/08 06:00
MHDA- 2020/05/08 06:01
PMCR- 2020/04/01
CRDT- 2020/05/08 06:00
PHST- 2020/05/08 06:00 [entrez]
PHST- 2020/05/08 06:00 [pubmed]
PHST- 2020/05/08 06:01 [medline]
PHST- 2020/04/01 00:00 [pmc-release]
AID - aeb.2019.513 [pii]
AID - 10.4183/aeb.2019.513 [doi]
PST - ppublish
SO  - Acta Endocrinol (Buchar). 2019 Oct-Dec;15(4):513-517. doi: 10.4183/aeb.2019.513.