PMID- 32377688
OWN - NLM
STAT- MEDLINE
DCOM- 20211203
LR  - 20211214
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Print)
IS  - 1047-3211 (Linking)
VI  - 30
IP  - 9
DP  - 2020 Jul 30
TI  - Focal Dorsal Hippocampal Nav1.1 Knock Down Alters Place Cell Temporal 
      Coordination and Spatial Behavior.
PG  - 5049-5066
LID - 10.1093/cercor/bhaa101 [doi]
AB  - Alterations in the voltage-gated sodium channel Nav.1.1 are implicated in various 
      neurological disorders, including epilepsy, Alzheimer's disease, and autism 
      spectrum disorders. Previous studies suggest that the reduction of Nav1.1 
      expression leads to a decrease of fast spiking activity in inhibitory neurons. 
      Because interneurons (INs) play a critical role in the temporal organization of 
      neuronal discharge, we hypothesize that Nav1.1 dysfunction will negatively impact 
      neuronal coordination in vivo. Using shRNA interference, we induced a focal 
      Nav1.1 knock-down (KD) in the dorsal region of the right hippocampus of adult 
      rats. Focal, unilateral Nav1.1 KD decreases the performance in a spatial novelty 
      recognition task and the firing rate in INs, but not in pyramidal cells. It 
      reduced theta/gamma coupling of hippocampal oscillations and induced a shift in 
      pyramidal cell theta phase preference. Nav1.1 KD degraded spatial accuracy and 
      temporal coding properties of place cells, such as theta phase precession and 
      compression of ongoing sequences. Aken together, these data demonstrate that a 
      deficit in Nav1.1 alters the temporal coordination of neuronal firing in CA1 and 
      impairs behaviors that rely on the integrity of this network. They highlight the 
      potential contribution of local inhibition in neuronal coordination and its 
      impact on behavior in pathological conditions.
CI  - (c) The Author(s) 2020. Published by Oxford University Press.
FAU - Sakkaki, Sophie
AU  - Sakkaki S
AD  - Department of Neurological Sciences, Larner College of Medicine, University of 
      Vermont, Burlington, VT 05405, USA.
AD  - IGF, Universite Montpellier, CNRS, INSERM, Montpellier 34094, France.
FAU - Barriere, Sylvain
AU  - Barriere S
AD  - Department of Neurological Sciences, Larner College of Medicine, University of 
      Vermont, Burlington, VT 05405, USA.
FAU - Bender, Alex C
AU  - Bender AC
AD  - Dartmouth Geisel School of Medicine, Hanover, NH 03755 ,USA.
FAU - Scott, Rod C
AU  - Scott RC
AD  - Department of Neurological Sciences, Larner College of Medicine, University of 
      Vermont, Burlington, VT 05405, USA.
AD  - UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
AD  - Department of Neurology, Great Ormond Street Hospital NHS Trust, London WC1N 3JH, 
      UK.
FAU - Lenck-Santini, Pierre-Pascal
AU  - Lenck-Santini PP
AD  - Department of Neurological Sciences, Larner College of Medicine, University of 
      Vermont, Burlington, VT 05405, USA.
AD  - INMED, INSERM, Aix-Marseille Univ, Marseille, France.
LA  - eng
GR  - R01 NS076763/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
RN  - 0 (NAV1.1 Voltage-Gated Sodium Channel)
RN  - 0 (Scn1a protein, rat)
SB  - IM
MH  - Animals
MH  - Gene Knockdown Techniques
MH  - Hippocampus/*physiology
MH  - Male
MH  - NAV1.1 Voltage-Gated Sodium Channel/*genetics
MH  - Place Cells/*physiology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Spatial Behavior/*physiology
PMC - PMC8475810
OTO - NOTNLM
OT  - CA1
OT  - Nav1.1
OT  - SC1NA
OT  - place cell
OT  - theta
EDAT- 2020/05/08 06:00
MHDA- 2021/12/15 06:00
PMCR- 2020/05/07
CRDT- 2020/05/08 06:00
PHST- 2019/07/03 00:00 [received]
PHST- 2020/03/26 00:00 [revised]
PHST- 2020/03/26 00:00 [accepted]
PHST- 2020/05/08 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2020/05/08 06:00 [entrez]
PHST- 2020/05/07 00:00 [pmc-release]
AID - 5831484 [pii]
AID - bhaa101 [pii]
AID - 10.1093/cercor/bhaa101 [doi]
PST - ppublish
SO  - Cereb Cortex. 2020 Jul 30;30(9):5049-5066. doi: 10.1093/cercor/bhaa101.