PMID- 32377996
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210921
IS  - 1434-9949 (Electronic)
IS  - 0770-3198 (Linking)
VI  - 39
IP  - 11
DP  - 2020 Nov
TI  - Serum homocysteine levels and their association with clinical characteristics of 
      inflammatory arthritis.
PG  - 3295-3302
LID - 10.1007/s10067-020-05093-5 [doi]
AB  - OBJECTIVE: The aim of our study was to explore the serum levels of homocysteine 
      (Hcy) and its association with clinical characteristics in patients with 
      different types of inflammatory arthritis. METHODS: A total of 242 patients 
      diagnosed with inflammatory arthritis (which included rheumatoid arthritis (RA), 
      ankylosing spondylitis (AS), and gout), 49 with osteoarthritis (OA), and 36 with 
      hyperuricaemia (HUA) and 81 healthy controls (HCs) were enrolled for comparisons. 
      RESULTS: The serum Hcy levels of patients with RA, AS, and OA were comparable 
      with those of the HC group (P > 0.05). However, the serum level of Hcy was 
      significantly higher in patients with gout than in HCs (18.75 +/- 9.98 vs. 
      14.20 +/- 6.22 mumol/L, P = 0.007). In addition, we found that the serum Hcy level 
      was much higher in RA patients who received methotrexate (MTX) therapy without 
      folic acid supplementation than in those who received MTX with folic acid 
      supplementation (13.39 +/- 4.80 vs. 9.41 +/- 2.04 mumol/L, P = 0.001). Furthermore, 
      there was a positive correlation between uric acid and Hcy in patients without 
      uric acid-lowering treatment (r = 0.537, P = 0.002), but the correlation was 
      eliminated after adjusting uric acid-lowering treatment (r = 0.139, P = 0.393). 
      Finally, consistent with the above findings, hyperhomocysteinaemia (HHcy) was 
      more common in gout patients (P < 0.05). CONCLUSION: Screening for HHcy in 
      patients with gout and RA, especially RA patients treated with MTX, might be 
      necessary, and patients with HHcy might benefit from earlier supplementation with 
      folic acid. Key Points * Serum homocysteine (Hcy) was elevated and the rate of 
      hyperhomocysteinaemia (HHcy) was significantly higher in gout. * Rheumatoid 
      arthritis (RA) patients who received methotrexate (MTX) treatment without folic 
      acid supplementation showed higher serum Hcy than those who received MTX 
      treatment with folic acid supplementation. * The serum Hcy level was positively 
      correlated with age in only RA patients. * Serum Hcy was correlated with uric 
      acid in gout patients, but the correlation was eliminated after adjusting uric 
      acid-lowering treatment.
FAU - Shu, Jianlong
AU  - Shu J
AD  - Department of Rheumatology, Guangxi International Zhuang Medicine Hospital, 
      Nanning, Guangxi, China.
FAU - Sun, Xinping
AU  - Sun X
AD  - Department of Clinical Laboratory, Peking University International Hospital, Life 
      Park Road No. 1 Life Science Park of Zhong Guancun, Chang Ping District, Beijing, 
      102206, China.
FAU - Li, Ji
AU  - Li J
AD  - Department of Rheumatology and Immunology, Peking University International 
      Hospital, Life Park Road No. 1 Life Science Park of Zhong Guancun, Chang Ping 
      District, Beijing, 102206, China.
FAU - Li, Fengzhen
AU  - Li F
AD  - Department of Rheumatology, Guangxi International Zhuang Medicine Hospital, 
      Nanning, Guangxi, China.
FAU - Tang, Jie
AU  - Tang J
AD  - Department of Rheumatology, Guangxi International Zhuang Medicine Hospital, 
      Nanning, Guangxi, China.
FAU - Shi, Lianjie
AU  - Shi L
AD  - Department of Rheumatology and Immunology, Peking University International 
      Hospital, Life Park Road No. 1 Life Science Park of Zhong Guancun, Chang Ping 
      District, Beijing, 102206, China. shilianjie1999@163.com.
LA  - eng
GR  - 81501396/National Natural Science Foundation of China/
GR  - 2016 M600874/China Postdoctoral Science Foundation/
GR  - YN2016QN01 and YN2017QX01/Peking University International Hospital Research 
      Funds/
PT  - Journal Article
DEP - 20200507
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
RN  - YL5FZ2Y5U1 (Methotrexate)
SB  - IM
MH  - *Arthritis, Rheumatoid/complications/drug therapy
MH  - Folic Acid
MH  - Homocysteine
MH  - Humans
MH  - Methotrexate/therapeutic use
MH  - *Spondylitis, Ankylosing
OTO - NOTNLM
OT  - Gout
OT  - Homocysteine
OT  - Inflammatory arthritis
OT  - Rheumatoid arthritis
EDAT- 2020/05/08 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/05/08 06:00
PHST- 2019/08/20 00:00 [received]
PHST- 2020/04/08 00:00 [accepted]
PHST- 2020/03/18 00:00 [revised]
PHST- 2020/05/08 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/05/08 06:00 [entrez]
AID - 10.1007/s10067-020-05093-5 [pii]
AID - 10.1007/s10067-020-05093-5 [doi]
PST - ppublish
SO  - Clin Rheumatol. 2020 Nov;39(11):3295-3302. doi: 10.1007/s10067-020-05093-5. Epub 
      2020 May 7.