PMID- 32378630
OWN - NLM
STAT- MEDLINE
DCOM- 20200812
LR  - 20200812
IS  - 0015-5691 (Print)
IS  - 0015-5691 (Linking)
VI  - 155
IP  - 3
DP  - 2020
TI  - [Novel molecules-related drug dependence in mice].
PG  - 140-144
LID - 10.1254/fpj.19127 [doi]
AB  - Shati/Nat8l and TMEM168 were identified from nucleus accumbens (NAcc), which 
      received continuous methamphetamine treatments. Shati/Nat8l is a synthetic enzyme 
      that produces N-acetylaspartate (NAA) from L-aspartate and acetyl-coenzyme NAA is 
      converted into N-acetylaspartylglutamate (NAAG) by NAAG synthetase (NAAGS). NAAG 
      works as a highly selective endogenous agonist for the metabotropic glutamate 
      type 3 receptor (mGluR3). We attempted to microinjection of adeno associated 
      virus (AAV) including Shati/Nat8l into mice NAcc. These NAcc-Shati/Nat8l mice 
      showed attenuation of the pharmacological effects of methamphetamine. NAcc-Shati 
      or TMEM168 mice were also produced by AAV strategy and these mice also attenuated 
      the methamphetamine-induced hyper locomotion and place preference test. TMEM168 
      interacts with osteopontin in NAcc of mice and cultured cells. Further, 
      osteopontin it self has suppressive effects of methamphetamine. TMEM168 enhances 
      anxiety in the elevated-plus maze and light-dark box test. The anxiety is 
      recovered by the treatment of antianxiety drug diazepam. There our serial studies 
      demonstrate that investigation of drug dependence-related molecule could lead to 
      new pathway for new target for psychiatric disease.
FAU - Nitta, Atsumi
AU  - Nitta A
AD  - Department of Pharmaceutical Therapy & Neuropharmacology, Faculty of 
      Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, University 
      of Toyama.
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Nihon Yakurigaku Zasshi
JT  - Nihon yakurigaku zasshi. Folia pharmacologica Japonica
JID - 0420550
RN  - 0 (Membrane Proteins)
RN  - 0 (Spp1 protein, mouse)
RN  - 106441-73-0 (Osteopontin)
RN  - 44RAL3456C (Methamphetamine)
RN  - EC 2.3.1.- (Acetyltransferases)
RN  - EC 2.3.1.- (Shati protein, mouse)
SB  - IM
MH  - Acetyltransferases/*metabolism
MH  - Animals
MH  - Membrane Proteins/*metabolism
MH  - *Methamphetamine
MH  - Mice
MH  - Nucleus Accumbens
MH  - Osteopontin
MH  - Substance-Related Disorders/*metabolism
EDAT- 2020/05/08 06:00
MHDA- 2020/08/13 06:00
CRDT- 2020/05/08 06:00
PHST- 2020/05/08 06:00 [entrez]
PHST- 2020/05/08 06:00 [pubmed]
PHST- 2020/08/13 06:00 [medline]
AID - 10.1254/fpj.19127 [doi]
PST - ppublish
SO  - Nihon Yakurigaku Zasshi. 2020;155(3):140-144. doi: 10.1254/fpj.19127.