PMID- 32378653
OWN - NLM
STAT- MEDLINE
DCOM- 20200730
LR  - 20200730
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Print)
IS  - 0918-2918 (Linking)
VI  - 59
IP  - 9
DP  - 2020
TI  - Risk Factors for Cardiovascular Events among Pregnant Women with Cardiovascular 
      Disease.
PG  - 1119-1124
LID - 10.2169/internalmedicine.3016-19 [doi]
AB  - Objective Cardiovascular disease increases the risk of maternal mortality. This 
      study examined the risk factors for cardiovascular events in pregnant women with 
      cardiovascular disease. Methods This was a case-control study conducted in 2 
      phases at Japanese maternal and fetal care centers. The primary survey, using an 
      interviewer-administered questionnaire, investigated whether the institutions had 
      managed pregnant women with cardiovascular disease from April 2014 to March 2016. 
      From 424 individual facilities surveyed, 135 facilities were found to have 
      experience in managing pregnant women. In the secondary survey, the 135 
      institutions were asked to complete a web-based questionnaire, which collected 
      detailed clinical information about cases, including cardiovascular disease, 
      cardiovascular events, maternal background, and the perinatal outcome. Results 
      Information on 302 pregnant women with cardiovascular disease was collected. None 
      of the 302 patients died. There were 25 women with cardiovascular events 
      (cardiovascular event group) and 277 women without cardiovascular events 
      (non-cardiovascular event group); the two groups were compared. No significant 
      differences were found in the perinatal outcomes. Medication use before pregnancy 
      was identified as a risk factor for cardiovascular events (adjusted odds ratio, 
      23.28; 95% confidence interval, 8.15-66.47; p<0.001). In pregnant women with 
      cardiovascular disease, New York Heart Association (NYHA) functional class II or 
      III before pregnancy was associated with a higher risk of cardiovascular events 
      in comparison to NYHA functional class I (p<0.001 for both). Conclusion 
      Medication use before pregnancy and NYHA functional class >I were risk factors 
      for cardiovascular events in pregnant women with cardiovascular disease.
FAU - Nii, Masafumi
AU  - Nii M
AD  - Department of Obstetrics and Gynecology, Mie University School of Medicine, 
      Japan.
FAU - Tanaka, Hiroaki
AU  - Tanaka H
AD  - Department of Obstetrics and Gynecology, Mie University School of Medicine, 
      Japan.
FAU - Tanaka, Kayo
AU  - Tanaka K
AD  - Department of Obstetrics and Gynecology, Mie University School of Medicine, 
      Japan.
FAU - Katsuragi, Shinji
AU  - Katsuragi S
AD  - Department of Obstetrics and Gynecology, Sakakibara Heart Institute, Japan.
FAU - A Kamiya, Chizuko
AU  - A Kamiya C
AD  - Division of Maternal Fetal Medicine and Gynecology, National Cerebral and 
      Cardiovascular Center, Japan.
FAU - Shiina, Yumi
AU  - Shiina Y
AD  - Department of Cardiology, St. Luke's International Hospital, Japan.
FAU - Niwa, Koichiro
AU  - Niwa K
AD  - Department of Cardiology, St. Luke's International Hospital, Japan.
FAU - Ikeda, Tomoaki
AU  - Ikeda T
AD  - Department of Obstetrics and Gynecology, Mie University School of Medicine, 
      Japan.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20200501
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
SB  - IM
MH  - Adult
MH  - Cardiovascular Diseases/*epidemiology/etiology
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Japan/epidemiology
MH  - Pregnancy
MH  - Pregnancy Complications, Cardiovascular/*epidemiology/etiology
MH  - Pregnancy Outcome
MH  - Prenatal Care
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Surveys and Questionnaires
PMC - PMC7270756
OTO - NOTNLM
OT  - cardiovascular disease
OT  - cardiovascular event
OT  - maternal death
OT  - pregnancy
COIS- The authors state that they have no Conflict of Interest (COI).
EDAT- 2020/05/08 06:00
MHDA- 2020/07/31 06:00
PMCR- 2020/05/01
CRDT- 2020/05/08 06:00
PHST- 2020/05/08 06:00 [entrez]
PHST- 2020/05/08 06:00 [pubmed]
PHST- 2020/07/31 06:00 [medline]
PHST- 2020/05/01 00:00 [pmc-release]
AID - 10.2169/internalmedicine.3016-19 [doi]
PST - ppublish
SO  - Intern Med. 2020;59(9):1119-1124. doi: 10.2169/internalmedicine.3016-19. Epub 
      2020 May 1.