PMID- 32378675
OWN - NLM
STAT- MEDLINE
DCOM- 20200911
LR  - 20200911
IS  - 1347-5231 (Electronic)
IS  - 0031-6903 (Linking)
VI  - 140
IP  - 5
DP  - 2020
TI  - [Research on Gliding and Discharge Performance of Suspended Injection from 
      Syringe -Effect of Diameter Ratio of Suspending Particle against Needle Hole on 
      Needle Passageability].
PG  - 711-722
LID - 10.1248/yakushi.19-00254 [doi]
AB  - Suspended injectable formulations such as sustained-release luteinizing 
      hormone-releasing hormone (LH-RH) analogue loaded in polylactic acid-glycolic 
      acid copolymer (PLGA) particles have been developed on market. Such formulations 
      have potential issue of suspended particles blocking the injection needle. In 
      this research, two types of injectability tests (gliding force, particles 
      discharge) were developed to evaluate the needle passageability of suspended 
      particles. The model suspension was newly designed using mono-dispersed 
      polyethylene (PE) spheres and qualified dispersing fluid to enhance universality 
      and validity of the test. The suspension-filled syringe, in which three sizes of 
      spheres (L, M, S) were dispersed, was vertically fixed and pushed by 
      auto-compression/tensile tester. The gliding force was continuously detected 
      during testing time and all discharged PE spheres were collected and weighed. The 
      combination of sphere (L, M, S) and injection needle were varied to evaluate the 
      effect of the diameter ratio of sphere against needle hole (D/W) on 
      passageability through needle. These injectability tests revealed that the 
      blockage of a needle hole was occasionally observed when the D/W value increased 
      up to 0.35-0.5, which was detected by jump-up of gliding force and drastic 
      decrease of discharged sphere. In addition, the effect of the formulation 
      properties (concentration of suspended spheres, viscosity of dispersing fluid) 
      and operational factor (injection speed) on injectability was also investigated. 
      The results from this study would be valuable in developing suspended injections 
      and predicting injection trouble at the medical scene.
FAU - Niwa, Toshiyuki
AU  - Niwa T
AD  - Laboratory of Industrial Pharmacy, Faculty of Pharmacy, Meijo University.
FAU - Morisaki, Megumi
AU  - Morisaki M
AD  - Laboratory of Industrial Pharmacy, Faculty of Pharmacy, Meijo University.
FAU - Kondo, Keita
AU  - Kondo K
AD  - Laboratory of Industrial Pharmacy, Faculty of Pharmacy, Meijo University.
FAU - Nakashima, Atsushi
AU  - Nakashima A
AD  - Laboratory of Industrial Pharmacy, Faculty of Pharmacy, Meijo University.
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Yakugaku Zasshi
JT  - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
JID - 0413613
RN  - 0 (Suspensions)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 9002-88-4 (Polyethylene)
SB  - IM
MH  - Drug Compounding
MH  - *Equipment Design
MH  - Injections
MH  - Mechanical Phenomena
MH  - *Needles
MH  - *Particle Size
MH  - Polyethylene
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Suspensions
MH  - *Syringes
OTO - NOTNLM
OT  - discharge
OT  - gliding force
OT  - injectability
OT  - needle passageability
OT  - suspended injection
EDAT- 2020/05/08 06:00
MHDA- 2020/09/12 06:00
CRDT- 2020/05/08 06:00
PHST- 2020/05/08 06:00 [entrez]
PHST- 2020/05/08 06:00 [pubmed]
PHST- 2020/09/12 06:00 [medline]
AID - 10.1248/yakushi.19-00254 [doi]
PST - ppublish
SO  - Yakugaku Zasshi. 2020;140(5):711-722. doi: 10.1248/yakushi.19-00254.