PMID- 32380131
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1872-8111 (Electronic)
IS  - 0168-0102 (Linking)
VI  - 156
DP  - 2020 Jul
TI  - Neurotransmission through dopamine D1 receptors is required for aversive memory 
      formation and Arc activation in the cerebral cortex.
PG  - 58-65
LID - S0168-0102(20)30206-6 [pii]
LID - 10.1016/j.neures.2020.04.006 [doi]
AB  - Dopaminergic neurotransmission is considered to play an important role not only 
      in reward-based learning, but also in aversive learning. Here, we investigated 
      the role of dopaminergic neurotransmission via dopamine D1 receptors (D1Rs) in 
      aversive memory formation in a passive avoidance test using D1R knockdown (KD) 
      mice, in which the expression of D1Rs can conditionally and reversibly be 
      controlled by doxycycline (Dox) treatment. We also performed whole-brain imaging 
      after aversive footshock stimulation in activity-regulated cytoskeleton protein 
      (Arc)-dVenus D1RKD mice, which were crossbred from Arc-dVenus transgenic mice and 
      D1RKD mice, to examine the distribution of Arc-controlled dVenus expression in 
      the hippocampus and cerebral cortex during aversive memory formation. Knockdown 
      of D1R expression following Dox treatment resulted in impaired performance in the 
      passive avoidance test and was associated with a decrease in dVenus expression in 
      the cerebral cortex (visual, somatosensory, and motor cortices), but not the 
      hippocampus, compared with control mice without Dox treatment. These findings 
      indicate that D1R-mediated dopaminergic transmission is critical for aversive 
      memory formation, specifically by influencing Arc expression in the cerebral 
      cortex.
CI  - Copyright (c) 2020. Published by Elsevier B.V.
FAU - Saito, Nae
AU  - Saito N
AD  - Department of Comparative and Experimental Medicine, Brain Research Institute, 
      Niigata University, 1-757 Asahimachidori, Chuo-ku, Niigata, 951-8585, Japan; 
      Department of Molecular and Cellular Medicine, Graduate School of Medical and 
      Dental Sciences, Niigata University, 1-757 Asahimachidori, Chuo-ku, Niigata, 
      951-8585, Japan.
FAU - Tainaka, Kazuki
AU  - Tainaka K
AD  - Department of System Pathology for Neurological Disorders, Brain Research 
      Institute, Niigata University, 1-757 Asahimachidori, Chuo-ku, Niigata, 951-8585, 
      Japan.
FAU - Macpherson, Tom
AU  - Macpherson T
AD  - Laboratory for Advanced Brain Functions, Institute for Protein Research, Osaka 
      University, 3-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
FAU - Hikida, Takatoshi
AU  - Hikida T
AD  - Laboratory for Advanced Brain Functions, Institute for Protein Research, Osaka 
      University, 3-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
FAU - Yamaguchi, Shun
AU  - Yamaguchi S
AD  - Department of Morphological Neuroscience, Graduate School of Medicine, Gifu 
      University, 1-1 Yanagido, Gifu City, Gifu, 501-1194, Japan; Center for Highly 
      Advanced Integration of Nano and Life Sciences, Gifu University, 1-1 Yanagido, 
      Gifu City, Gifu, 501-1194, Japan.
FAU - Sasaoka, Toshikuni
AU  - Sasaoka T
AD  - Department of Comparative and Experimental Medicine, Brain Research Institute, 
      Niigata University, 1-757 Asahimachidori, Chuo-ku, Niigata, 951-8585, Japan. 
      Electronic address: sasaoka@bri.niigata-u.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20200505
PL  - Ireland
TA  - Neurosci Res
JT  - Neuroscience research
JID - 8500749
RN  - 0 (Receptors, Dopamine D1)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Dopamine
MH  - Hippocampus/metabolism
MH  - *Memory
MH  - Mice
MH  - *Receptors, Dopamine D1/metabolism
MH  - Synaptic Transmission
OTO - NOTNLM
OT  - Arc
OT  - Arg3.1
OT  - Aversive memory
OT  - Dopamine D1 receptor
OT  - Three-dimensional imaging
OT  - Venus
COIS- Declaration of Competing Interest None.
EDAT- 2020/05/08 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/05/08 06:00
PHST- 2019/09/27 00:00 [received]
PHST- 2020/04/22 00:00 [revised]
PHST- 2020/04/24 00:00 [accepted]
PHST- 2020/05/08 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/05/08 06:00 [entrez]
AID - S0168-0102(20)30206-6 [pii]
AID - 10.1016/j.neures.2020.04.006 [doi]
PST - ppublish
SO  - Neurosci Res. 2020 Jul;156:58-65. doi: 10.1016/j.neures.2020.04.006. Epub 2020 
      May 5.