PMID- 32380873 OWN - NLM STAT- MEDLINE DCOM- 20210426 LR - 20220415 IS - 1747-4132 (Electronic) IS - 1747-4124 (Linking) VI - 14 IP - 6 DP - 2020 Jun TI - Insights and updates on endoscopic papillectomy. PG - 435-444 LID - 10.1080/17474124.2020.1766965 [doi] AB - INTRODUCTION: Endoscopic papillectomy (EP) has been established as a useful endoscopic therapy by the efforts of many pancreatobiliary endoscopists and is presently accepted as a reliable alternative therapy to surgery in patients with ampullary adenoma. Moreover, there have been numerous advancements in EP techniques in recent years. Various approaches and attempts toward expanding the indications of endoscopic resection have been reported. Furthermore, the management and prevention of adverse events (AEs) and endoscopic treatment for remnant or recurrent lesions have also been reported. In the present review, we focus on recent advancements in the EP technique, as well as speculate on the future issues of EP. AREA COVERED: This review of EP encompasses the indications, preoperative assessments, endoscopic techniques, outcomes, and AEs of EP, post-EP surveillance techniques, and treatments for remnant or recurrence lesions. EXPERT OPINION: The ultimate goal of EP is the complete resection of ampullary tumors, regardless of whether they are adenomatous or carcinomatous lesions, without causing any AEs. Therefore, the most important issue is preoperative evaluation, that is, the accurate diagnosis of lesions contraindicated for EP. In addition, further research on the prevention of AEs is also necessary towards establishing EP as a safe endoscopic procedure. FAU - Yamamoto, Kenjiro AU - Yamamoto K AD - Department of Gastroenterology and Hepatology, Tokyo Medical University , Tokyo, Japan. FAU - Iwasaki, Eisuke AU - Iwasaki E AD - Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine , Tokyo, Japan. FAU - Itoi, Takao AU - Itoi T AD - Department of Gastroenterology and Hepatology, Tokyo Medical University , Tokyo, Japan. LA - eng PT - Journal Article PT - Review DEP - 20200522 PL - England TA - Expert Rev Gastroenterol Hepatol JT - Expert review of gastroenterology & hepatology JID - 101278199 SB - IM MH - Adenoma/diagnosis/*surgery MH - Ampulla of Vater/*surgery MH - Common Bile Duct Neoplasms/diagnosis/*surgery MH - Digestive System Surgical Procedures/adverse effects/methods/trends MH - Duodenoscopy MH - Forecasting MH - Humans MH - Perioperative Care MH - Precancerous Conditions/diagnosis/*surgery MH - *Sphincterotomy, Endoscopic/adverse effects/methods/trends OTO - NOTNLM OT - Ampullary adenomas OT - ampullary carcinoma OT - endoscopic ablative therapy OT - endoscopic papillectomy OT - endoscopic ultrasonography OT - familial adenomatous polyposis OT - intraductal radiofrequency ablation OT - intraductal ultrasonography OT - post-EP pancreatitis OT - prophylactic pancreatic stent EDAT- 2020/05/10 06:00 MHDA- 2021/04/27 06:00 CRDT- 2020/05/09 06:00 PHST- 2020/05/10 06:00 [pubmed] PHST- 2021/04/27 06:00 [medline] PHST- 2020/05/09 06:00 [entrez] AID - 10.1080/17474124.2020.1766965 [doi] PST - ppublish SO - Expert Rev Gastroenterol Hepatol. 2020 Jun;14(6):435-444. doi: 10.1080/17474124.2020.1766965. Epub 2020 May 22.