PMID- 32382573
OWN - NLM
STAT- MEDLINE
DCOM- 20210209
LR  - 20220414
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2020
DP  - 2020
TI  - Omega-3 Polyunsaturated Fatty Acid Supplementation for Reducing Muscle Soreness 
      after Eccentric Exercise: A Systematic Review and Meta-Analysis of Randomized 
      Controlled Trials.
PG  - 8062017
LID - 10.1155/2020/8062017 [doi]
LID - 8062017
AB  - PURPOSE: This systematic review and meta-analysis was performed to determine the 
      effectiveness of Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplement on 
      muscle soreness after eccentric exercise. METHODS: PubMed, EMBASE, CENTRAL, and 
      ISI Web of Science were searched to identify randomized controlled trials (RCTs) 
      that assessed the efficacy of n-3 PUFA on muscle soreness after eccentric 
      exercise. Mean difference (MD) and the associated 95% confidence interval (95% 
      CI) were calculated by RevMan 5.3 to indicate delayed onset muscle soreness 
      (DOMS) that measured two days after eccentric trainings. Subgroup analyses 
      according to duration and daily dosage of n-3 PUFA supplements before eccentric 
      exercises were performed to determine whether these factors will influence the 
      overall effect size. The Grading of Recommendations, Assessment, Development, and 
      Evaluation (GRADE) approach was used to evaluate the certainty of evidence. The 
      protocol of this systematic review and meta-analysis was registered at PROSPERO 
      (CRD42018085869). RESULTS: 12 RCTs containing 145 subjects and 156 controls were 
      included in this study. Meta-analysis revealed a significantly decreased DOMS (MD 
      -0.93; 95% CI -1.44, -0.42; P = 0.0004) in n-3 PUFA supplement groups, while no 
      significant differences in isometric muscle strength and range of motion (ROM) 
      were detected. However, the pooled effect size for DOMS was lower than the 
      minimal clinically important difference (MCID) of 1.4 on the 10-unit VAS, 
      suggesting that the effect size of less muscle soreness with n-3 PUFA supplements 
      did not appear to be clinically relevant. CONCLUSION: There is low-quality 
      evidence that n-3 PUFA supplementation does not result in a clinically important 
      reduction of muscle soreness after eccentric exercise. Isometric muscle soreness 
      and range of motion were not improved by n-3 PUFA supplementation either 
      (low-quality evidence). To further elucidate the overall role of n-3 PUFA on 
      muscle damage in this area, large-scale RCTs are still needed.
CI  - Copyright (c) 2020 Zheng-tao Lv et al.
FAU - Lv, Zheng-Tao
AU  - Lv ZT
AUID- ORCID: 0000-0002-8238-7194
AD  - Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430030, China.
FAU - Zhang, Jin-Ming
AU  - Zhang JM
AUID- ORCID: 0000-0002-7657-1526
AD  - Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430030, China.
FAU - Zhu, Wen-Tao
AU  - Zhu WT
AUID- ORCID: 0000-0002-4177-5633
AD  - Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430030, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20200420
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Fatty Acids, Omega-3)
SB  - IM
MH  - *Dietary Supplements
MH  - Fatty Acids, Omega-3/*therapeutic use
MH  - Humans
MH  - *Myalgia/drug therapy/physiopathology
MH  - Randomized Controlled Trials as Topic
PMC - PMC7195643
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2020/05/10 06:00
MHDA- 2021/02/10 06:00
PMCR- 2020/04/20
CRDT- 2020/05/09 06:00
PHST- 2020/01/29 00:00 [received]
PHST- 2020/02/29 00:00 [revised]
PHST- 2020/03/02 00:00 [accepted]
PHST- 2020/05/09 06:00 [entrez]
PHST- 2020/05/10 06:00 [pubmed]
PHST- 2021/02/10 06:00 [medline]
PHST- 2020/04/20 00:00 [pmc-release]
AID - 10.1155/2020/8062017 [doi]
PST - epublish
SO  - Biomed Res Int. 2020 Apr 20;2020:8062017. doi: 10.1155/2020/8062017. eCollection 
      2020.