PMID- 32383088
OWN - NLM
STAT- MEDLINE
DCOM- 20220324
LR  - 20240130
IS  - 1532-6551 (Electronic)
IS  - 1071-3581 (Linking)
VI  - 28
IP  - 6
DP  - 2021 Dec
TI  - Increased myocardial oxygen consumption rates are associated with maladaptive 
      right ventricular remodeling and decreased event-free survival in heart failure 
      patients.
PG  - 2784-2795
LID - 10.1007/s12350-020-02144-x [doi]
AB  - BACKGROUND: Reduced left ventricular (LV) function is associated with increased 
      myocardial oxygen consumption rate (MVO(2)) and altered sympathetic activity, the 
      role of which is not well described in right ventricular (RV) dysfunction. 
      METHODS AND RESULTS: 33 patients with left heart failure were assessed for RV 
      function/size using echocardiography. Positron emission tomography (PET) was used 
      to measure (11)C-acetate clearance rate (k(mono)), (11)C-hydroxyephedrine 
      ((11)C-HED) standardized uptake value (SUV), and retention rate. RV MVO(2) was 
      estimated from k(mono). (11)C-HED SUV and retention indicated sympathetic 
      neuronal function. A composite clinical endpoint was defined as unplanned cardiac 
      hospitalization within 5 years. Patients with (n = 10) or without (n = 23) RV 
      dysfunction were comparable in terms of sex (male: 70.0 vs 69.5%), LV ejection 
      fraction (39.6 +/- 9.0 vs 38.6 +/- 9.4%), and systemic hypertension (70.0 vs 78.3%). 
      RV dysfunction patients were older (70.9 +/- 13.5 vs 59.4 +/- 11.5 years; P = .03) 
      and had a higher prevalence of pulmonary hypertension (60.0% vs 13.0%; P = .01). 
      RV dysfunction was associated with increased RV MVO(2) (.106 +/- .042 vs 
      .068 +/- .031 mL/min/g; P = .02) and decreased (11)C-HED SUV and retention 
      (6.05 +/- .53 vs 7.40 +/- 1.39 g/mL (P < .001) and .08 +/- .02 vs .11 +/- .03 mL/min/g 
      (P < .001), respectively). Patients with an RV MVO(2) above the median had a 
      shorter event-free survival (hazard ratio = 5.47; P = .01). Patients who died 
      within the 5-year follow-up period showed a trend (not statistically significant) 
      for higher RV MVO(2) (.120 +/- .026 vs .074 +/- .038 mL/min/g; P = .05). CONCLUSIONS: 
      RV dysfunction is associated with increased oxygen consumption (also 
      characterized by a higher risk for cardiac events) and impaired RV sympathetic 
      function.
CI  - (c) 2020. American Society of Nuclear Cardiology.
FAU - Ahmadi, Ali
AU  - Ahmadi A
AD  - Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, 
      Ottawa, ON, K1Y 4W7, Canada.
FAU - Renaud, Jennifer M
AU  - Renaud JM
AD  - National Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, ON, 
      Canada.
FAU - Promislow, Steven
AU  - Promislow S
AD  - Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, 
      Ottawa, ON, K1Y 4W7, Canada.
FAU - Burwash, Ian G
AU  - Burwash IG
AD  - Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, 
      Ottawa, ON, K1Y 4W7, Canada.
FAU - Dwivedi, Girish
AU  - Dwivedi G
AD  - Harry Perkins Institute of Medical Research, The University of Western Australia, 
      Perth, Australia.
FAU - Klein, Ran
AU  - Klein R
AD  - Division of Nuclear Medicine, The Ottawa Hospital, Ottawa, ON, Canada.
FAU - Zelt, Jason G E
AU  - Zelt JGE
AD  - Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, 
      Ottawa, ON, K1Y 4W7, Canada.
AD  - Department of Cellular and Molecular Medicine, Faculty of Medicine, University of 
      Ottawa, Ottawa, ON, Canada.
FAU - deKemp, Robert A
AU  - deKemp RA
AD  - National Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, ON, 
      Canada.
FAU - Beanlands, Rob S
AU  - Beanlands RS
AD  - Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, 
      Ottawa, ON, K1Y 4W7, Canada.
AD  - National Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, ON, 
      Canada.
FAU - Mielniczuk, Lisa M
AU  - Mielniczuk LM
AD  - Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, 
      Ottawa, ON, K1Y 4W7, Canada. lmielniczuk@ottawaheart.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200507
PL  - United States
TA  - J Nucl Cardiol
JT  - Journal of nuclear cardiology : official publication of the American Society of 
      Nuclear Cardiology
JID - 9423534
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Heart Failure/complications/*metabolism/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*metabolism
MH  - *Oxygen Consumption
MH  - Progression-Free Survival
MH  - Retrospective Studies
MH  - Ventricular Dysfunction, Right/complications/*metabolism/physiopathology
MH  - *Ventricular Remodeling
OTO - NOTNLM
OT  - Heart Failure
OT  - Metabolism imaging agents
OT  - PET
OT  - RV function
EDAT- 2020/05/10 06:00
MHDA- 2022/03/25 06:00
CRDT- 2020/05/09 06:00
PHST- 2019/02/14 00:00 [received]
PHST- 2020/02/14 00:00 [accepted]
PHST- 2020/05/10 06:00 [pubmed]
PHST- 2022/03/25 06:00 [medline]
PHST- 2020/05/09 06:00 [entrez]
AID - S1071-3581(23)01678-1 [pii]
AID - 10.1007/s12350-020-02144-x [doi]
PST - ppublish
SO  - J Nucl Cardiol. 2021 Dec;28(6):2784-2795. doi: 10.1007/s12350-020-02144-x. Epub 
      2020 May 7.