PMID- 32383204
OWN - NLM
STAT- MEDLINE
DCOM- 20211028
LR  - 20211028
IS  - 1096-9101 (Electronic)
IS  - 0196-8092 (Linking)
VI  - 52
IP  - 10
DP  - 2020 Dec
TI  - Device-Induced Neocollagenesis: Profibrotic Response or True Neocollagenesis?
PG  - 1010-1019
LID - 10.1002/lsm.23258 [doi]
AB  - BACKGROUND AND OBJECTIVES: Many light and radiofrequency-based rejuvenation 
      devices have claimed to increase collagen production in the skin dermal tissue. 
      However, there has not been enough scientific evidence to prove whether the 
      result is just a profibrotic response or not. We aimed to find the optimal skin 
      rejuvenation device that shows true neocollagenesis. STUDY DESIGN/MATERIALS AND 
      METHODS: We evaluated dermal collagen thickness and gene expression of 
      procollagen type 1, 3, matrix metalloproteinase-3 (MMP-3), and transforming 
      growth factor-beta (TGF-beta) resulting from different energy-based devices in a rat 
      model in vivo. The wound-healing response was evaluated histologically and by 
      real-time polymerase chain reaction (RT-PCR) at immediate, 1st, 2nd, 4th, 8th, 
      and 12th week after the initial procedure. RESULTS: At the 12th week, the most 
      relevant changes of the dermal thickness were found in specimens after treatment 
      with electrosurgical unit, fractional CO(2) and 1064 nm Q-switched Nd:YAG. 
      Procollagen 1 and 3 were also found to be the highest in electrosurgical unit, 
      fractional CO(2) , and microneedle radiofrequency. Dramatic changes of MMP-3 and 
      TGF-beta were remarkable at the early observation but went back to normal level at 
      12th week. The ratio of procollagen 1 and 3 was found to be the lowest with 
      Q-Switched Nd:YAG 1064 nm and fractional CO(2) . CONCLUSION: Electrosurgical unit 
      resulted in most significant changes, but due to irreversible thermal damage and 
      extremely high procollagen results it is considered as a profibrotic response. 
      Fractional CO(2) and Q-Switched Nd:YAG 1064 nm are applicable to face skin 
      rejuvenation treatment considering thickening of dermal tissue and lower 
      procollagen 1:3 ratio similar to the neocollagenesis purpose. Lasers Surg. Med. (c) 
      2020 Wiley Periodicals LLC.
CI  - (c) 2020 Wiley Periodicals LLC.
FAU - Natari, Sheila
AU  - Natari S
AD  - Department of Dermatology, College of Medicine, Korea University, 145, Anam-ro, 
      Seongbuk-gu, Seoul, 02831, Republic of Korea.
FAU - Kim, Ko Eun
AU  - Kim KE
AUID- ORCID: 0000-0002-4141-204X
AD  - Department of Dermatology, College of Medicine, Korea University, 145, Anam-ro, 
      Seongbuk-gu, Seoul, 02831, Republic of Korea.
AD  - Department of Dermatology, Korea University Ansan Hospital, 123, Jeokgeum-ro, 
      Danwon-gu, Ansan-si, Gyeonggi-do, 15355, Republic of Korea.
FAU - Ryu, Sook In
AU  - Ryu SI
AUID- ORCID: 0000-0002-9880-4837
AD  - Department of Dermatology, College of Medicine, Korea University, 145, Anam-ro, 
      Seongbuk-gu, Seoul, 02831, Republic of Korea.
AD  - Department of Dermatology, Korea University Ansan Hospital, 123, Jeokgeum-ro, 
      Danwon-gu, Ansan-si, Gyeonggi-do, 15355, Republic of Korea.
FAU - Park, Ji Hyun
AU  - Park JH
AUID- ORCID: 0000-0003-4856-1774
AD  - Department of Dermatology, College of Medicine, Korea University, 145, Anam-ro, 
      Seongbuk-gu, Seoul, 02831, Republic of Korea.
AD  - Barabom Dermatologic Clinic, 153, Wiryedong-ro, Sujeong-gu, Seongnam-si, 
      Gyeonggi-do, 13642, Republic of Korea.
FAU - Kim, Il-Hwan
AU  - Kim IH
AUID- ORCID: 0000-0002-4225-002X
AD  - Department of Dermatology, College of Medicine, Korea University, 145, Anam-ro, 
      Seongbuk-gu, Seoul, 02831, Republic of Korea.
AD  - Department of Dermatology, Korea University Ansan Hospital, 123, Jeokgeum-ro, 
      Danwon-gu, Ansan-si, Gyeonggi-do, 15355, Republic of Korea.
LA  - eng
PT  - Case Reports
DEP - 20200507
PL  - United States
TA  - Lasers Surg Med
JT  - Lasers in surgery and medicine
JID - 8007168
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Animals
MH  - Collagen
MH  - *Lasers, Solid-State
MH  - Rats
MH  - Rejuvenation
MH  - Skin
MH  - *Skin Aging
MH  - Wound Healing
OTO - NOTNLM
OT  - energy-based devices
OT  - neocollagenesis
OT  - procollagen type 1/3 ratio
OT  - profibrotic response
EDAT- 2020/05/10 06:00
MHDA- 2021/10/29 06:00
CRDT- 2020/05/09 06:00
PHST- 2019/12/03 00:00 [received]
PHST- 2020/03/19 00:00 [revised]
PHST- 2020/04/21 00:00 [accepted]
PHST- 2020/05/10 06:00 [pubmed]
PHST- 2021/10/29 06:00 [medline]
PHST- 2020/05/09 06:00 [entrez]
AID - 10.1002/lsm.23258 [doi]
PST - ppublish
SO  - Lasers Surg Med. 2020 Dec;52(10):1010-1019. doi: 10.1002/lsm.23258. Epub 2020 May 
      7.