PMID- 32383366
OWN - NLM
STAT- MEDLINE
DCOM- 20210120
LR  - 20210120
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Print)
IS  - 1011-8934 (Linking)
VI  - 35
IP  - 18
DP  - 2020 May 11
TI  - Effects of Lactobacillus pentosus in Children with Allergen-Sensitized Atopic 
      Dermatitis.
PG  - e128
LID - 10.3346/jkms.2020.35.e128 [doi]
LID - e128
AB  - BACKGROUND: Recent studies have shown that oral administration of probiotics may 
      improve the immune imbalance caused by dysbiosis of the gut microbiome in atopic 
      dermatitis (AD). This study aimed to investigate the clinical and immunological 
      effects of Lactobacillus pentosus in children with mild to moderate AD. METHODS: 
      Children aged 2-13 years with AD were randomized to receive either 1.0 x 10(10) 
      colony-forming units of L. pentosus or placebo, daily, for 12 weeks. The clinical 
      severity of AD and transepidermal water loss were evaluated. Blood eosinophil 
      counts, serum total immunoglobulin E (IgE), and cytokine levels were measured. 
      The diversity and composition of the gut microbiota were also analyzed. RESULTS: 
      Eighty-two children were recruited, and 41 were assigned to the probiotics 
      intervention group. The mean scoring of atopic dermatitis (SCORAD) indices at 
      baseline were 30.4 and 34.3 for the probiotics and placebo groups, respectively. 
      At week 12, the mean indices were 23.6 and 23.1 for the probiotics and placebo 
      groups, respectively. Clinical severity decreased significantly over time in both 
      groups, with no significant difference between the two groups. In both groups, 
      there were no significant differences in cytokine levels, microbial diversity, or 
      the relative abundance of the gut microbiota at week 12 compared with the 
      corresponding baseline values. The mean subjective scores of SCORAD indices after 
      intervention for the probiotics group were significantly lower than those for the 
      placebo group in IgE sensitized AD (P = 0.019). CONCLUSION: Our results show 
      improved symptoms in the probiotics and placebo groups, and we could not find 
      additional effects of L. pentosus in AD. However, the mean subjective scores of 
      SCORAD indices for the probiotics group are significantly improved compared with 
      those for the placebo group in allergen-sensitized AD.
CI  - (c) 2020 The Korean Academy of Medical Sciences.
FAU - Ahn, So Hyun
AU  - Ahn SH
AUID- ORCID: 0000-0002-1323-5488
AD  - Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
FAU - Yoon, Wonsuck
AU  - Yoon W
AUID- ORCID: 0000-0002-7665-7629
AD  - Allergy Immunology Center, Korea University, Seoul, Korea.
FAU - Lee, So Young
AU  - Lee SY
AUID- ORCID: 0000-0002-5020-5982
AD  - Research Division of Food Functionality, Korea Food Research Institute, Wanju, 
      Korea.
AD  - KFRI School, Korea University of Science and Technology, Wanju, Korea.
FAU - Shin, Hee Soon
AU  - Shin HS
AUID- ORCID: 0000-0002-0942-7161
AD  - Research Division of Food Functionality, Korea Food Research Institute, Wanju, 
      Korea.
AD  - KFRI School, Korea University of Science and Technology, Wanju, Korea.
FAU - Lim, Mi Young
AU  - Lim MY
AUID- ORCID: 0000-0003-4881-1710
AD  - Research Division of Food Functionality, Korea Food Research Institute, Wanju, 
      Korea.
FAU - Nam, Young Do
AU  - Nam YD
AUID- ORCID: 0000-0002-2660-3569
AD  - Research Division of Food Functionality, Korea Food Research Institute, Wanju, 
      Korea.
FAU - Yoo, Young
AU  - Yoo Y
AUID- ORCID: 0000-0003-3354-6969
AD  - Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
AD  - Allergy Immunology Center, Korea University, Seoul, Korea. yoolina@korea.ac.kr.
LA  - eng
GR  - E0170400-01/MOE/Ministry of Environment/Korea
GR  - NRF-2018R1A6A3A11049961/NRF/National Research Foundation of Korea/Korea
GR  - NRF-2019R1F1A1041169/NRF/National Research Foundation of Korea/Korea
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20200511
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 0 (Allergens)
RN  - 0 (Cytokines)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/blood
MH  - Dermatitis, Atopic/immunology/pathology/*therapy
MH  - Double-Blind Method
MH  - Eosinophils/cytology/metabolism
MH  - Feces/microbiology
MH  - Female
MH  - Gastrointestinal Microbiome
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Lactobacillus pentosus/*immunology
MH  - Leukocyte Count
MH  - Male
MH  - Placebo Effect
MH  - Probiotics/administration & dosage
MH  - Severity of Illness Index
PMC - PMC7211510
OTO - NOTNLM
OT  - Atopic Dermatitis
OT  - Lactobacillus pentosus
OT  - Microbiome
OT  - Probiotics
COIS- The authors have no potential conflicts of interest to disclose.
EDAT- 2020/05/10 06:00
MHDA- 2021/01/21 06:00
PMCR- 2020/05/11
CRDT- 2020/05/09 06:00
PHST- 2019/09/24 00:00 [received]
PHST- 2020/03/05 00:00 [accepted]
PHST- 2020/05/09 06:00 [entrez]
PHST- 2020/05/10 06:00 [pubmed]
PHST- 2021/01/21 06:00 [medline]
PHST- 2020/05/11 00:00 [pmc-release]
AID - 35.e128 [pii]
AID - 10.3346/jkms.2020.35.e128 [doi]
PST - epublish
SO  - J Korean Med Sci. 2020 May 11;35(18):e128. doi: 10.3346/jkms.2020.35.e128.