PMID- 32384512
OWN - NLM
STAT- MEDLINE
DCOM- 20200601
LR  - 20221207
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 99
IP  - 19
DP  - 2020 May
TI  - Early-onset type 2 diabetes: A high-risk factor for proliferative diabetic 
      retinopathy (PDR) in patients with microalbuminuria.
PG  - e20189
LID - 10.1097/MD.0000000000020189 [doi]
LID - e20189
AB  - We aim to explore the relationship between early-onset diabetes and proliferative 
      diabetic retinopathy (PDR) in type 2 diabetes mellitus (T2DM) patients with 
      microalbuminuria.A total of 461 T2DM patients with microalbuminuria were 
      enrolled. Subjects were defined as early-onset or late-onset based on the age at 
      which they were diagnosed with diabetes (<40 and >/=40 years, respectively). 
      Medical history, anthropometry, and laboratory indicators were documented. PDR 
      was defined as the presence of any of the following changes on fundus 
      photography: neovascularization, vitreous hemorrhage, or preretinal 
      hemorrhage.The prevalence of PDR was 6-fold higher in patients with early-onset 
      than late-onset T2DM [(6.1% vs 1.0%), P = .004]. Univariate correlation analysis 
      showed that early-onset diabetes, use of oral hypoglycemic drugs, and insulin 
      therapy were risk factors for PDR. In multivariate logistic analysis, patients 
      with early-onset diabetes exhibited a 7.00-fold [(95% confidence interval 
      1.40-38.26), P = .019] higher risk of PDR than subjects with late-onset diabetes 
      after adjusting for sex; T2DM duration; systolic blood pressure; total 
      triglyceride; glycated hemoglobin; insulin therapy; and the use of oral 
      hypoglycemic drugs, antihypertensive drugs, and lipid-lowering drugs.In T2DM 
      patients with microalbuminuria, early-onset diabetes is an independent risk 
      factor for the development of PDR.
FAU - Lv, Xinlu
AU  - Lv X
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing.
FAU - Ran, Xi
AU  - Ran X
AD  - Department of Endocrinology, The Affiliated Yanan Hospital of Kunming Medical 
      University, Kunming, Yunnan, China.
FAU - Chen, Xiangjun
AU  - Chen X
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing.
FAU - Luo, Ting
AU  - Luo T
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing.
FAU - Hu, Jinbo
AU  - Hu J
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing.
FAU - Wang, Yue
AU  - Wang Y
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing.
FAU - Liu, Zhiping
AU  - Liu Z
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing.
FAU - Zhen, Qianna
AU  - Zhen Q
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing.
FAU - Liu, Xiurong
AU  - Liu X
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing.
FAU - Zheng, Li
AU  - Zheng L
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing.
FAU - Tang, Ying
AU  - Tang Y
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing.
FAU - Zhao, Qinying
AU  - Zhao Q
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing.
FAU - Han, Shichao
AU  - Han S
AD  - Statistics and Computer Science, University of California, Berkeley, CA.
FAU - Zhou, Yangmei
AU  - Zhou Y
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing.
FAU - Luo, Wenjin
AU  - Luo W
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing.
FAU - Yang, Lina
AU  - Yang L
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing.
FAU - Li, Qifu
AU  - Li Q
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing.
FAU - Wang, Zhihong
AU  - Wang Z
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Hypolipidemic Agents)
RN  - 0 (Lipids)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Aged
MH  - Aged, 80 and over
MH  - Albuminuria/classification/*epidemiology
MH  - Antihypertensive Agents/therapeutic use
MH  - Blood Pressure
MH  - Body Weights and Measures
MH  - Diabetes Mellitus, Type 2/drug therapy/*epidemiology
MH  - Diabetic Retinopathy/*epidemiology
MH  - Female
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Hypoglycemic Agents/therapeutic use
MH  - Hypolipidemic Agents/therapeutic use
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Young Adult
PMC - PMC7220424
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2020/05/10 06:00
MHDA- 2020/06/02 06:00
PMCR- 2020/05/08
CRDT- 2020/05/09 06:00
PHST- 2020/05/09 06:00 [entrez]
PHST- 2020/05/10 06:00 [pubmed]
PHST- 2020/06/02 06:00 [medline]
PHST- 2020/05/08 00:00 [pmc-release]
AID - 00005792-202005080-00089 [pii]
AID - MD-D-20-00515 [pii]
AID - 10.1097/MD.0000000000020189 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2020 May;99(19):e20189. doi: 10.1097/MD.0000000000020189.