PMID- 32385022
OWN - NLM
STAT- MEDLINE
DCOM- 20200818
LR  - 20200818
IS  - 1000-503X (Print)
IS  - 1000-503X (Linking)
VI  - 42
IP  - 2
DP  - 2020 Apr 28
TI  - [Predictive Value of Pancreatic Steatosis for Severity of Coronary 
      Atherosclerosis in Patients with Type 2 Diabetes Mellitus].
PG  - 172-177
LID - 10.3881/j.issn.1000-503X.11524 [doi]
AB  - Objective To investigate the association of pancreatic steatosis with coronary 
      atherosclerosis in patients with type 2 diabetes mellitus (T2DM). Methods 
      Patients with T2DM who underwent coronary computed tomography angiography(CCTA)in 
      our center due to chest pain were enrolled from January 2016 to February 2019. 
      According to the CCTA findings,patients were divided into normal 
      group,mild-to-moderate coronary atherosclerosis group and severe coronary 
      atherosclerosis group. CT attenuation of pancreas and spleen was measured on 
      abdominal non-enhanced CT,and the CT attenuation indexes including the difference 
      between pancreatic and splenic attenuation (P-S) and the ratio of 
      pancreas-to-spleen attenuation (P/S) were calculated. Analysis of variance or 
      Kruskal-Wallis rank test were used to assess differences among each group. 
      Logistic regression analysis was used to analyze the risk factors of severe 
      coronary stenosis. The accuracy of P/S in predicting severe coronary artery 
      stenosis was assessed by receiver operator characteristic (ROC) curve analysis. 
      Results A total of 173 consecutive T2DM patients were enrolled. These patients 
      included 27 patients with normal coronary artery (15.6%),124 patients with mild 
      to moderate stenosis (71.7%),and 22 patients with severe stenosis (12.7%). There 
      were significant differences in CT attenuation of pancreas (Z=11.543,P=0.003),P-S 
      (Z=11.152,P=0.004) and P/S (Z=11.327,P=0.004) among normal coronary artery 
      group,mild and moderate stenosis group,and severe stenosis group. The CT 
      attenuation of pancreatic head,body,and tail significantly differed in patients 
      with coronary artery stenosis (Z=14.737,P=0.001). After adjusting for confounding 
      factors,multiple Logistic regression showed that P/S 
      (OR=0.062,95%CI=0.008-0.487,P=0.008) was still significantly associated with the 
      severe coronary artery stenosis. The area under the ROC curve of P/S for the 
      diagnosis of severe coronary artery stenosis was 0.701,and the optimal cutoff 
      point was 0.660. Conclusion CT attenuation of pancreas and CT attenuation indexes 
      are associated with the severity of coronary stenosis in T2DM patients,suggesting 
      that pancreatic steatosis may be used as one of the indicators for predicting 
      severe coronary artery stenosis.
FAU - Sun, Peng-Tao
AU  - Sun PT
AD  - Department of Radiology,Beijing Shijitan Hospital,Capital Medical 
      University,Beijing 100038,China.
FAU - DU, Xue-Chao
AU  - DU XC
AD  - Department of Radiology,Beijing Chaoyang Hospital,Capital Medical 
      University,Beijing 100043,China.
FAU - Wang, Ruo-Dun
AU  - Wang RD
AD  - Medical Department,Xiamen Humanity Hospital,Xiamen,Fujian 361006,China.
FAU - Sun, Ying
AU  - Sun Y
AD  - Department of Radiology,Beijing Shijitan Hospital,Capital Medical 
      University,Beijing 100038,China.
FAU - Sun, Xiao-Li
AU  - Sun XL
AD  - Department of Radiology,Beijing Shijitan Hospital,Capital Medical 
      University,Beijing 100038,China.
FAU - Zhao, Tong
AU  - Zhao T
AD  - Department of Radiology,Beijing Shijitan Hospital,Capital Medical 
      University,Beijing 100038,China.
FAU - Wei, Hai-Liang
AU  - Wei HL
AD  - Department of Radiology,Beijing Shijitan Hospital,Capital Medical 
      University,Beijing 100038,China.
FAU - Wang, Ren-Gui
AU  - Wang RG
AD  - Department of Radiology,Beijing Shijitan Hospital,Capital Medical 
      University,Beijing 100038,China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao
JT  - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
JID - 8006230
SB  - IM
MH  - Coronary Angiography
MH  - Coronary Artery Disease/*complications
MH  - *Coronary Stenosis
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Humans
MH  - Pancreas/*pathology
MH  - Predictive Value of Tests
OTO - NOTNLM
OT  - computed tomography
OT  - coronary artery disease
OT  - diabetes mellitus
OT  - pancreatic fat
EDAT- 2020/05/10 06:00
MHDA- 2020/08/19 06:00
CRDT- 2020/05/10 06:00
PHST- 2020/05/10 06:00 [entrez]
PHST- 2020/05/10 06:00 [pubmed]
PHST- 2020/08/19 06:00 [medline]
AID - 10.3881/j.issn.1000-503X.11524 [doi]
PST - ppublish
SO  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2020 Apr 28;42(2):172-177. doi: 
      10.3881/j.issn.1000-503X.11524.