PMID- 32385644 OWN - NLM STAT- MEDLINE DCOM- 20201116 LR - 20201116 IS - 1435-1102 (Electronic) IS - 1434-1816 (Linking) VI - 23 IP - 5 DP - 2020 Oct TI - Exploring the relationship of insight with psychopathology and gender in individuals with schizophrenia spectrum disorders with structural equation modelling. PG - 643-655 LID - 10.1007/s00737-020-01031-1 [doi] AB - To model the influence of psychopathology on insight deficits in schizophrenia spectrum patients with a gender-stratified analysis. Five hundred sixteen patients (65.1% men) with schizophrenia spectrum disorders were evaluated in four centres of the metropolitan area of Barcelona (Catalonia). Psychopathological assessment was performed using different PANSS factors. Insight and its three main dimensions were assessed by means of the Scale of Unawareness of Mental Disorder: awareness of the disease (SUMD-1), of the effect of medication (SUMD-2) and of the social consequences of the disease (SUMD-3). Structural equation models (SEMs) were used to fix the model in the total sample and by gender. Additional analyses included age, duration of illness (DOI) and education status (ES). There were no significant differences between men and women in the three main dimensions of insight. The SEMs in the total sample showed a modest fitting capacity. Fitting improved after a gender-stratified analysis (particularly in women). In men, positive and excited symptoms were associated with poorer insight in all SUMD dimensions, whereas depressive symptoms were associated with better insight. ES in men was also associated with better SUMD-2 or SUMD-3. In contrast, in women, symptoms did not have a negative effect on SUMD-1 or SUMD-2. However, positive symptoms were associated with a poorer SUMD-3, whereas depressive symptoms were associated with better SUMD-3. Moreover, education level was also associated with a better SUMD-3. A gender approach improved the comprehension of the model, supporting the relevance of gender analysis in the study of insight. FAU - Cobo, Jesus AU - Cobo J AD - Mental Health Department. Corporacio Sanitaria Parc Tauli, Hospital Universitari - UAB - CIBERSAM, Parc Tauli, 1, 08208, Sabadell, Barcelona, Catalonia, Spain. jcobo@tauli.cat. AD - Department of Psychiatry and Forensic Medicine, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Catalonia, Spain. jcobo@tauli.cat. AD - Research Workgroup on Womens' Mental Health, Catalan Society of Psychiatry & Mental Health, Barcelona, Catalonia, Spain. jcobo@tauli.cat. FAU - Labad, Javier AU - Labad J AD - Mental Health Department. Corporacio Sanitaria Parc Tauli, Hospital Universitari - UAB - CIBERSAM, Parc Tauli, 1, 08208, Sabadell, Barcelona, Catalonia, Spain. AD - Department of Psychiatry and Forensic Medicine, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Catalonia, Spain. AD - Research Workgroup on Womens' Mental Health, Catalan Society of Psychiatry & Mental Health, Barcelona, Catalonia, Spain. FAU - Pousa, Esther AU - Pousa E AD - Servei de Psiquiatria. Hospital Sant Pau, Barcelona, Catalonia, Spain. FAU - Nieto, Lourdes AU - Nieto L AD - Research Workgroup on Womens' Mental Health, Catalan Society of Psychiatry & Mental Health, Barcelona, Catalonia, Spain. AD - Department of Research, Instituto Nacional de Psiquiatria Ramon de la Fuente Muniz, Mexico D.F., Mexico. FAU - Ochoa, Susana AU - Ochoa S AD - Research Workgroup on Womens' Mental Health, Catalan Society of Psychiatry & Mental Health, Barcelona, Catalonia, Spain. AD - Research and Development Unit, Parc Sanitari San Joan de Deu - CIBERSAM, Sant Boi de Llobregat, Barcelona, Catalonia, Spain. FAU - Usall, Judith AU - Usall J AD - Research Workgroup on Womens' Mental Health, Catalan Society of Psychiatry & Mental Health, Barcelona, Catalonia, Spain. AD - Research and Development Unit, Parc Sanitari San Joan de Deu - CIBERSAM, Sant Boi de Llobregat, Barcelona, Catalonia, Spain. FAU - Garcia-Ribera, Carles AU - Garcia-Ribera C AD - Servei de Psiquiatria. Hospital Sant Pau, Barcelona, Catalonia, Spain. FAU - Banos, Iris AU - Banos I AD - Research and Development Unit, Parc Sanitari San Joan de Deu - CIBERSAM, Sant Boi de Llobregat, Barcelona, Catalonia, Spain. FAU - Gonzalez, Beatriz AU - Gonzalez B AD - Mental Health Department, Hospital Benito Menni, Sant Boi de Llobregat, Barcelona, Catalonia, Spain. FAU - Massons, Carmina AU - Massons C AD - Mental Health Department. Corporacio Sanitaria Parc Tauli, Hospital Universitari - UAB - CIBERSAM, Parc Tauli, 1, 08208, Sabadell, Barcelona, Catalonia, Spain. FAU - Ruiz, Isabel AU - Ruiz I AD - Department of Health and Clinical Psychology - Research Unit, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Catalonia, Spain. FAU - Ruiz, Ada I AU - Ruiz AI AD - Research Workgroup on Womens' Mental Health, Catalan Society of Psychiatry & Mental Health, Barcelona, Catalonia, Spain. AD - Servei de Psiquiatria. Hospital del Mar. Parc de Salut Mar, Barcelona, Catalonia, Spain. LA - eng PT - Journal Article DEP - 20200508 PL - Austria TA - Arch Womens Ment Health JT - Archives of women's mental health JID - 9815663 SB - IM MH - Adult MH - *Awareness MH - Female MH - Humans MH - *Latent Class Analysis MH - Male MH - Middle Aged MH - Psychiatric Status Rating Scales MH - Psychometrics MH - Psychopathology MH - Psychotic Disorders/*psychology MH - *Schizophrenia MH - *Schizophrenic Psychology MH - Sex Factors MH - Spain MH - Surveys and Questionnaires OTO - NOTNLM OT - Awareness OT - Depression OT - Positive OT - Psychosis OT - Women EDAT- 2020/05/10 06:00 MHDA- 2020/11/18 06:00 CRDT- 2020/05/10 06:00 PHST- 2019/06/28 00:00 [received] PHST- 2020/04/07 00:00 [accepted] PHST- 2020/05/10 06:00 [pubmed] PHST- 2020/11/18 06:00 [medline] PHST- 2020/05/10 06:00 [entrez] AID - 10.1007/s00737-020-01031-1 [pii] AID - 10.1007/s00737-020-01031-1 [doi] PST - ppublish SO - Arch Womens Ment Health. 2020 Oct;23(5):643-655. doi: 10.1007/s00737-020-01031-1. Epub 2020 May 8.