PMID- 32386774
OWN - NLM
STAT- MEDLINE
DCOM- 20210401
LR  - 20210401
IS  - 1618-0631 (Electronic)
IS  - 0344-0338 (Linking)
VI  - 216
IP  - 6
DP  - 2020 Jun
TI  - Rare variants of solitary fibrous tumor.
PG  - 152989
LID - S0344-0338(20)30498-2 [pii]
LID - 10.1016/j.prp.2020.152989 [doi]
AB  - OBJECTIVE: Some cases of solitary fibrous tumor (SFT) exhibit unusual histologic 
      features that may cause diagnostic difficulty, such as fascicular monotonous 
      spindle cells accompanied by hyalinized blood vessels and numerous evenly 
      distributed mast cells, and features mimicking myxoid liposarcoma. Awareness of 
      these features is important for reaching correct diagnosis of similar cases. 
      METHODS: Three cases of SFT with the above unusual features were retrieved from 
      our consult files for review, including H&E slides and immunohistochemical 
      stains. In addition, FISH analysis for SS18-SSX (SYT), DDIT3 and MDM2 were 
      performed. Furthermore, formalin-fixed paraffin-embedded (FFPE) tissue sections 
      were tested for 8 fusion variants of NAB2-STAT6 by qualitative endpoint 
      reverse-transcriptase (RT)-PCR. RESULTS: Neoplastic cells from all 3 cases are 
      positive for CD34, CD99, and STAT6 immunohistochemically. In addition, the tumors 
      are positive for NAB2-STAT6 fusion gene. Mast cells from the first case possess 
      nonneoplastic phenotype and are positive for CD117 and tryptase staining but 
      negative for CD25. CONCLUSIONS: The three cases studied here represent rare types 
      of SFT, which differ from classical "pattern-less" pattern of SFT. Correct 
      diagnosis required a combination of CD34 and STAT6 immunostaining and NAB2-STAT6 
      fusion gene analysis.
CI  - Copyright (c) 2020 Elsevier GmbH. All rights reserved.
FAU - Tian, Sufang
AU  - Tian S
AD  - Department of Pathology, Zhongnan Hospital of Wuhan University, China; Wuhan 
      University Center for Pathology and Molecular Diagnostics, Wuhan, Hubei Province, 
      China. Electronic address: usa2005tiansufang@hotmail.com.
FAU - Guo, Jianchun
AU  - Guo J
AD  - Department of Pathology, Zhongnan Hospital of Wuhan University, China; Wuhan 
      University Center for Pathology and Molecular Diagnostics, Wuhan, Hubei Province, 
      China. Electronic address: znpathowhu@163.com.
FAU - Tang, Xianbin
AU  - Tang X
AD  - Department of Pathology, Taihe Hospital, Shiyan, Hubei Province, China. 
      Electronic address: tangxianbin@yeah.net.
FAU - Liu, Yufei
AU  - Liu Y
AD  - Department of Pathology, Yichang Central People's Hospital, Yichang, Hubei 
      Province, China. Electronic address: 402762573@qq.com.
FAU - Chen, Honglei
AU  - Chen H
AD  - Department of Pathology, Zhongnan Hospital of Wuhan University, China; Wuhan 
      University Center for Pathology and Molecular Diagnostics, Wuhan, Hubei Province, 
      China. Electronic address: hl-chen@whu.edu.cn.
FAU - Cai, Yuxiang
AU  - Cai Y
AD  - Department of Pathology, Zhongnan Hospital of Wuhan University, China; Wuhan 
      University Center for Pathology and Molecular Diagnostics, Wuhan, Hubei Province, 
      China. Electronic address: grzzlbl@sina.com.
FAU - Xiao, Shu-Yuan
AU  - Xiao SY
AD  - Department of Pathology, Zhongnan Hospital of Wuhan University, China; Wuhan 
      University Center for Pathology and Molecular Diagnostics, Wuhan, Hubei Province, 
      China; Department of Pathology, University of Chicago, Chicago, IL, 60637, USA. 
      Electronic address: pathoznwhu@sina.com.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20200425
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (NAB2 protein, human)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (Repressor Proteins)
RN  - 0 (STAT6 Transcription Factor)
RN  - 0 (STAT6 protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/*analysis
MH  - Female
MH  - Humans
MH  - Male
MH  - Oncogene Proteins, Fusion/genetics
MH  - Repressor Proteins/genetics
MH  - STAT6 Transcription Factor/genetics
MH  - Solitary Fibrous Tumors/*diagnosis/genetics/*pathology
MH  - Young Adult
OTO - NOTNLM
OT  - NAB2-STAT6 fusion
OT  - Solitary fibrous tumor
OT  - histomorphology
OT  - mast cell-rich
OT  - myxoid
EDAT- 2020/05/11 06:00
MHDA- 2021/04/02 06:00
CRDT- 2020/05/11 06:00
PHST- 2020/02/23 00:00 [received]
PHST- 2020/04/21 00:00 [accepted]
PHST- 2020/05/11 06:00 [pubmed]
PHST- 2021/04/02 06:00 [medline]
PHST- 2020/05/11 06:00 [entrez]
AID - S0344-0338(20)30498-2 [pii]
AID - 10.1016/j.prp.2020.152989 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2020 Jun;216(6):152989. doi: 10.1016/j.prp.2020.152989. Epub 
      2020 Apr 25.