PMID- 32388410
OWN - NLM
STAT- MEDLINE
DCOM- 20210623
LR  - 20210623
IS  - 1879-0593 (Electronic)
IS  - 1368-8375 (Linking)
VI  - 107
DP  - 2020 Aug
TI  - A critical evaluation of computed tomography-derived depth of invasion in the 
      preoperative assessment of oral cancer staging.
PG  - 104749
LID - S1368-8375(20)30185-8 [pii]
LID - 10.1016/j.oraloncology.2020.104749 [doi]
AB  - BACKGROUND: Depth of invasion (DOI) has been introduced into the latest TNM 
      classification of oral squamous cell carcinoma (OSCC). Despite its primarily 
      pathological definition (pDOI), a preoperative evaluation of a radiological DOI 
      (rDOI) would be useful but a standard and practical definition is lacking. The 
      primary aim of this study is to measure the rDOI by computed tomography (CT) and 
      compare it to the pDOI in a cohort of OSCC patients. Then, we analyze the utility 
      and reliability of rDOI in the preoperative setting. METHODS: 58 cases of OSCC 
      operated at our Institution from 2016 to 2019 were included. After accounting for 
      plane-specific shrinkage factors and for different oral subsites, we have 
      compared pDOI and rDOI for each spatial plane by paired difference test and 
      correlation coefficient. Radiological accuracy and survival analysis were also 
      determined to identify rDOI's clinical value. RESULTS: For lateral tongue, pDOI 
      was more strongly related with axial rDOI (P < 0.01); for hard palate, the best 
      plane was the sagittal one (P < 0.01); in floor of mouth (FOM) lesions, the 
      strongest correlation was with coronal rDOI (P < 0.01), as well as for cheek 
      buccal mucosa; sagittal scans seem to be the best to evaluate dorsum of the 
      tongue and retromolar trigone; gingiva (P < 0.01) was most correctly evaluated in 
      the coronal plane. Overall accuracy of rDOI restaging was 75.41%. Disease-free 
      survival seems to be worse as rDOI increases. CONCLUSIONS: We suggest that with a 
      standardized imaging protocol patients could be better classified according to 
      CT-derived DOI.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Locatello, Luca Giovanni
AU  - Locatello LG
AD  - Department of Otorhinolaryngology, Careggi University Hospital, Florence, Italy. 
      Electronic address: locatello.lucagiovanni@gmail.com.
FAU - Bruno, Chiara
AU  - Bruno C
AD  - Department of Otorhinolaryngology, Careggi University Hospital, Florence, Italy.
FAU - Pietragalla, Michele
AU  - Pietragalla M
AD  - Department of Radiology, Careggi University Hospital, Florence, Italy.
FAU - Taverna, Cecilia
AU  - Taverna C
AD  - Department of Pathology, Careggi University Hospital, Florence, Italy.
FAU - Novelli, Luca
AU  - Novelli L
AD  - Department of Pathology, Careggi University Hospital, Florence, Italy.
FAU - Nardi, Cosimo
AU  - Nardi C
AD  - Department of Radiology, Careggi University Hospital, Florence, Italy.
FAU - Bonasera, Luigi
AU  - Bonasera L
AD  - Department of Radiology, Careggi University Hospital, Florence, Italy.
FAU - Cannavicci, Angelo
AU  - Cannavicci A
AD  - Department of Otorhinolaryngology, Careggi University Hospital, Florence, Italy.
FAU - Maggiore, Giandomenico
AU  - Maggiore G
AD  - Department of Otorhinolaryngology, Careggi University Hospital, Florence, Italy.
FAU - Gallo, Oreste
AU  - Gallo O
AD  - Department of Otorhinolaryngology, Careggi University Hospital, Florence, Italy.
LA  - eng
PT  - Journal Article
DEP - 20200507
PL  - England
TA  - Oral Oncol
JT  - Oral oncology
JID - 9709118
SB  - IM
MH  - Carcinoma, Squamous Cell/*diagnostic imaging/pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Mouth Neoplasms/*diagnostic imaging/pathology
MH  - Neoplasm Staging
MH  - Preoperative Period
MH  - Tomography, X-Ray Computed/*methods
OTO - NOTNLM
OT  - Head and neck cancer
OT  - Oral cancer
OT  - Pathology
OT  - Radiology
OT  - Staging
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/05/11 06:00
MHDA- 2021/06/24 06:00
CRDT- 2020/05/11 06:00
PHST- 2019/11/11 00:00 [received]
PHST- 2020/04/24 00:00 [accepted]
PHST- 2020/05/11 06:00 [pubmed]
PHST- 2021/06/24 06:00 [medline]
PHST- 2020/05/11 06:00 [entrez]
AID - S1368-8375(20)30185-8 [pii]
AID - 10.1016/j.oraloncology.2020.104749 [doi]
PST - ppublish
SO  - Oral Oncol. 2020 Aug;107:104749. doi: 10.1016/j.oraloncology.2020.104749. Epub 
      2020 May 7.