PMID- 32388902
OWN - NLM
STAT- MEDLINE
DCOM- 20210831
LR  - 20210831
IS  - 1442-9071 (Electronic)
IS  - 1442-6404 (Linking)
VI  - 48
IP  - 6
DP  - 2020 Aug
TI  - Study of peripapillary vascular flow using optical coherence tomography 
      angiography in optic nerve head drusen.
PG  - 775-782
LID - 10.1111/ceo.13783 [doi]
AB  - IMPORTANCE: To evaluate peripapillary vascular flow using optical coherence 
      tomography angiography (angio-OCT) in patients with optic nerve head drusen 
      (ONHD). BACKGROUND: Angio-OCT allows non-invasive visualization and 
      quantification peripapillary vascular flow. DESIGN: Cross-sectional study. 
      PARTICIPANTS: Seventy-six eyes of 40 patients. METHODS: Between January 2018 and 
      May 2019, consecutive patients with ONHD and healthy controls underwent a 
      complete ocular assessment, including visual acuity testing, biomicroscopy, 
      tonometry, funduscopy, automated perimetry, retinography and autofluorescence, 
      spectral-domain OCT and peripapillary angio-OCT. MAIN OUTCOMES MEASURES: 
      Peripapillary vascular flow, vascular density, retinal nerve fibre layer (RNFL) 
      and ganglion cell layer (GCL) thicknesses. RESULTS: We included 23 patients with 
      ONHD (42 eyes, 32 with visible drusen; mean age 50.96 years, 12 men) and 17 
      control patients (34 eyes; mean age 47.12 years, 7 men), without significant 
      differences in age or sex. Vascular flow and density were significantly lower in 
      patients with ONHD (0.409% and 40.18%, respectively) than in normal eyes (0.438% 
      and 43.30%, respectively) (P = .006 and P < .001). RNFL and GCL thicknesses were 
      significantly lower in patients with ONHD (81.81 and 77.43 mum, respectively) than 
      in controls (91.38 and 81.97 mum, respectively) (P = .001 and P = .032). We 
      obtained high correlation indexes between RNFL and GCL and vascular flow and 
      density (RNFL = 0.702 and 0.744, respectively, and GCL = 0.808 and 0.857, 
      respectively). CONCLUSIONS AND RELEVANCE: Angio-OCT demonstrated significant 
      reductions in peripapillary vascular flow and vascular density in patients with 
      ONHD, with strong correlations with RNFL and GCL thicknesses.
CI  - (c) 2020 Royal Australian and New Zealand College of Ophthalmologists.
FAU - Leal-Gonzalez, Mercedes
AU  - Leal-Gonzalez M
AD  - Ophthalmology Unit, Hospital Universitario Fundacion Alcorcon, Madrid, Spain.
FAU - Pessanha, Filipa
AU  - Pessanha F
AD  - Ophthalmology Unit, Hospital Universitario Fundacion Alcorcon, Madrid, Spain.
FAU - Azevedo Gonzalez-Oliva, Martim
AU  - Azevedo Gonzalez-Oliva M
AD  - Ophthalmology Unit, Hospital Universitario Fundacion Alcorcon, Madrid, Spain.
FAU - Perez-Fernandez, Elia
AU  - Perez-Fernandez E
AD  - Research Unit, Hospital Universitario Fundacion Alcorcon, Madrid, Spain.
FAU - Gili, Pablo
AU  - Gili P
AUID- ORCID: 0000-0002-5013-4459
AD  - Ophthalmology Unit, Hospital Universitario Fundacion Alcorcon, Madrid, Spain.
LA  - eng
PT  - Journal Article
DEP - 20200531
PL  - Australia
TA  - Clin Exp Ophthalmol
JT  - Clinical & experimental ophthalmology
JID - 100896531
SB  - IM
MH  - Angiography
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers
MH  - *Optic Disk
MH  - Retinal Ganglion Cells
MH  - *Tomography, Optical Coherence
MH  - Visual Acuity
OTO - NOTNLM
OT  - angiography
OT  - ganglion cell complex
OT  - optic nerve drusen
OT  - optical coherence tomography
OT  - retinal nerve fibre layer
EDAT- 2020/05/11 06:00
MHDA- 2021/09/01 06:00
CRDT- 2020/05/11 06:00
PHST- 2019/12/24 00:00 [received]
PHST- 2020/05/01 00:00 [revised]
PHST- 2020/05/06 00:00 [accepted]
PHST- 2020/05/11 06:00 [pubmed]
PHST- 2021/09/01 06:00 [medline]
PHST- 2020/05/11 06:00 [entrez]
AID - 10.1111/ceo.13783 [doi]
PST - ppublish
SO  - Clin Exp Ophthalmol. 2020 Aug;48(6):775-782. doi: 10.1111/ceo.13783. Epub 2020 
      May 31.