PMID- 32389012
OWN - NLM
STAT- MEDLINE
DCOM- 20210224
LR  - 20210224
IS  - 2224-5839 (Electronic)
IS  - 2224-5820 (Linking)
VI  - 9
IP  - 3
DP  - 2020 May
TI  - Efficacy and safety of Qinzhuliangxue decoction for treating atopic eczema: a 
      randomized controlled trial.
PG  - 870-882
LID - 10.21037/apm.2020.04.17 [doi]
AB  - BACKGROUND: Atopic eczema is the most common type of skin disorder in both 
      children and adults. It is characterized by erythema, pruritus, papules, 
      xeransis, and lichenification. Qinzhuliangxue decoction (QZLXD), a Chinese herbal 
      medicine (CHM) prepared with several ingredients that are used to treat eczema, 
      was formulated according to the traditional Chinese medicine (TCM) theory. This 
      study aimed to investigate the efficacy and safety of QZLXD administration for 
      treating atopic eczema compared to those of Runzaozhiyang capsules (RZZYC). 
      METHODS: A total of 176 patients were enrolled at the Shanghai Yueyang Hospital 
      and were randomly assigned to the QZLXD treatment group (n=82) or the RZZYC 
      control group (n=86). The differences in Eczema Area and Severity Index (EASI), 
      Dermatology Life Quality Index, itching score, recurrence rate, and adverse 
      events (AEs) were compared between the groups. RESULTS: The EASI score 
      (x2=14.181, P=0.003), recurrence rate (x2=7.398, P=0.007), and itching score 
      (F=-3.427, P=0.001) were lower in the QZLXD group than in the RZZYC group. 
      Incidence of AEs was similar between the RZZYC and QZLXD groups (P=0.434). 
      CONCLUSIONS: QZLXD is recommended for the treatment of subacute atopic eczema 
      because QZLXD showed good efficiency with low recurrence rate and tolerable AEs.
FAU - Ma, Tian
AU  - Ma T
AD  - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and 
      Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 
      200437, China.
FAU - Chai, Yuanyuan
AU  - Chai Y
AD  - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and 
      Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 
      200437, China; Department of Surgery of Traditional Chinese Medicine, Xiangshan 
      Traditional Chinese Medicine Hospital, Shanghai 200020, China.
FAU - Li, Su
AU  - Li S
AD  - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and 
      Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 
      200437, China.
FAU - Sun, Xiaoying
AU  - Sun X
AD  - Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, 
      Shanghai 201203, China.
FAU - Wang, Yifei
AU  - Wang Y
AD  - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and 
      Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 
      200437, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese 
      Medicine, Shanghai 201203, China.
FAU - Xu, Rong
AU  - Xu R
AD  - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and 
      Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 
      200437, China.
FAU - Chen, Jie
AU  - Chen J
AD  - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and 
      Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 
      200437, China.
FAU - Zhou, Mi
AU  - Zhou M
AD  - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and 
      Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 
      200437, China.
FAU - Zhou, Min
AU  - Zhou M
AD  - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and 
      Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 
      200437, China.
FAU - Li, Bin
AU  - Li B
AD  - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and 
      Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 
      200437, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese 
      Medicine, Shanghai 201203, China.
FAU - Xu, Wenbin
AU  - Xu W
AD  - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and 
      Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 
      200437, China. xuwenbin@shyueyanghospital.com.
FAU - Li, Xin
AU  - Li X
AD  - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and 
      Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 
      200437, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese 
      Medicine, Shanghai 201203, China. 13661956326@163.com.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20200426
PL  - China
TA  - Ann Palliat Med
JT  - Annals of palliative medicine
JID - 101585484
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (qinzhu liangxue)
SB  - IM
MH  - Adult
MH  - Child
MH  - China
MH  - *Dermatitis, Atopic/drug therapy
MH  - *Drugs, Chinese Herbal/therapeutic use
MH  - *Eczema/drug therapy
MH  - Humans
MH  - *Medicine, Chinese Traditional
MH  - Severity of Illness Index
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Atopic eczema
OT  - Qinzhuliangxue decoction (QZLXD)
OT  - clinical research
EDAT- 2020/05/12 06:00
MHDA- 2021/02/25 06:00
CRDT- 2020/05/12 06:00
PHST- 2019/10/09 00:00 [received]
PHST- 2020/02/14 00:00 [accepted]
PHST- 2020/05/12 06:00 [pubmed]
PHST- 2021/02/25 06:00 [medline]
PHST- 2020/05/12 06:00 [entrez]
AID - apm.2020.04.17 [pii]
AID - 10.21037/apm.2020.04.17 [doi]
PST - ppublish
SO  - Ann Palliat Med. 2020 May;9(3):870-882. doi: 10.21037/apm.2020.04.17. Epub 2020 
      Apr 26.