PMID- 32389293
OWN - NLM
STAT- MEDLINE
DCOM- 20210820
LR  - 20210820
IS  - 1878-6146 (Print)
VI  - 124
IP  - 5
DP  - 2020 May
TI  - Telomeres and stress in yeast cells: When genes and environment interact.
PG  - 311-315
LID - S1878-6146(19)30124-2 [pii]
LID - 10.1016/j.funbio.2019.09.003 [doi]
AB  - Telomeres are structures composed of simple DNA repeats and specific proteins 
      that protect the eukaryotic chromosomal ends from degradation, and facilitate the 
      replication of the genome. They are central to the maintenance of the genome 
      integrity, and play important roles in the development of cancer and in the 
      process of aging in humans. The yeast Saccharomyces cerevisiae has greatly 
      contributed to our understanding of basic telomere biology. Our laboratory has 
      carried out systematic screen for mutants that affect telomere length, and 
      identified  approximately 500 genes that, when mutated, affect telomere length. Remarkably, all 
       approximately 500 TLM (Telomere Length Maintenance) genes participate in a very tight 
      homeostatic process, and it is enough to mutate one of them to change the 
      steady-state telomere length. Despite this complex network of balances, it is 
      also possible to change telomere length in yeast by applying several types of 
      external stresses. We summarize our insights about the molecular mechanisms by 
      which genes and environment interact to affect telomere length.
CI  - Copyright (c) 2019 British Mycological Society. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Harari, Yaniv
AU  - Harari Y
AD  - School of Molecular Cell Biology and Biotechnology, Tel Aviv University, Ramat 
      Aviv, 69978, Israel.
FAU - Gershon, Lihi
AU  - Gershon L
AD  - School of Molecular Cell Biology and Biotechnology, Tel Aviv University, Ramat 
      Aviv, 69978, Israel.
FAU - Alonso-Perez, Elisa
AU  - Alonso-Perez E
AD  - School of Molecular Cell Biology and Biotechnology, Tel Aviv University, Ramat 
      Aviv, 69978, Israel.
FAU - Klein, Shir
AU  - Klein S
AD  - School of Molecular Cell Biology and Biotechnology, Tel Aviv University, Ramat 
      Aviv, 69978, Israel.
FAU - Berneman, Yael
AU  - Berneman Y
AD  - School of Molecular Cell Biology and Biotechnology, Tel Aviv University, Ramat 
      Aviv, 69978, Israel.
FAU - Choudhari, Karan
AU  - Choudhari K
AD  - School of Molecular Cell Biology and Biotechnology, Tel Aviv University, Ramat 
      Aviv, 69978, Israel.
FAU - Singh, Pragyan
AU  - Singh P
AD  - School of Molecular Cell Biology and Biotechnology, Tel Aviv University, Ramat 
      Aviv, 69978, Israel.
FAU - Sau, Soumitra
AU  - Sau S
AD  - Amity Institute of Biotechnology, Amity University Kolkata, Kolkata, India.
FAU - Liefshitz, Batia
AU  - Liefshitz B
AD  - School of Molecular Cell Biology and Biotechnology, Tel Aviv University, Ramat 
      Aviv, 69978, Israel.
FAU - Kupiec, Martin
AU  - Kupiec M
AD  - School of Molecular Cell Biology and Biotechnology, Tel Aviv University, Ramat 
      Aviv, 69978, Israel. Electronic address: martin@tauex.tau.ac.il.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190913
PL  - Netherlands
TA  - Fungal Biol
JT  - Fungal biology
JID - 101524465
SB  - IM
MH  - *Environment
MH  - Humans
MH  - Mutation
MH  - *Saccharomyces cerevisiae/genetics
MH  - *Stress, Physiological/genetics
MH  - *Telomere/genetics
MH  - Telomere Homeostasis/genetics
OTO - NOTNLM
OT  - Aging
OT  - Caffeine
OT  - Cancer
OT  - Ethanol
OT  - Genome stability
OT  - Saccharomyces cerevisiae
EDAT- 2020/05/12 06:00
MHDA- 2021/08/21 06:00
CRDT- 2020/05/12 06:00
PHST- 2019/06/28 00:00 [received]
PHST- 2019/09/09 00:00 [revised]
PHST- 2019/09/09 00:00 [accepted]
PHST- 2020/05/12 06:00 [entrez]
PHST- 2020/05/12 06:00 [pubmed]
PHST- 2021/08/21 06:00 [medline]
AID - S1878-6146(19)30124-2 [pii]
AID - 10.1016/j.funbio.2019.09.003 [doi]
PST - ppublish
SO  - Fungal Biol. 2020 May;124(5):311-315. doi: 10.1016/j.funbio.2019.09.003. Epub 
      2019 Sep 13.