PMID- 32390045
OWN - NLM
STAT- MEDLINE
DCOM- 20210331
LR  - 20210331
IS  - 1945-239X (Electronic)
IS  - 0021-9665 (Linking)
VI  - 58
IP  - 6
DP  - 2020 Jun 5
TI  - Rapid Analysis of Four Amphetamines in Urine by Self-Made Pipette-Tip Solid-Phase 
      Extraction Followed by GC-MS/MS.
PG  - 569-575
LID - 10.1093/chromsci/bmaa018 [doi]
AB  - A simple and rapid pipette-tip solid-phase extraction (PT-SPE) procedure with 
      derivatization prior to gas chromatography triple quadrupole mass spectrometry 
      analysis is developed for the simultaneous determination of amphetamine (AMP), 
      methamphetamine (MA), 3,4-methylenedioxyamphetamine (MDA) and 
      3,4-methylenedioxymethamphetamine (MDMA) in urine samples. The PT-SPE procedure 
      using self-made sorbent could extract drugs within 6 min from 100-muL urine 
      samples, requiring low solvent-consumption (<2.0 mL). Besides, the self-made 
      pipette tip could be reused at least five times. Under optimized conditions, the 
      recoveries of four amphetamines at spiked levels (low, medium and high) ranged 
      from 87.7 to 110.4%, with relative standard deviations < 9.5%. The limit of 
      detections and limit of quantifications for AMP, MA, MDA and MDMA were in the 
      range of 2.52-8.25 ng⋅mL-1 and 8.4-27.5 ng⋅mL-1, respectively. Validation results 
      show that the proposed method is suitable for the quantitation of amphetamines 
      and has been successfully applied in the urine samples of suspected drug abusers.
CI  - (c) The Author(s) 2020. Published by Oxford University Press. All rights reserved. 
      For permissions, please email: journals.permissions@oup.com.
FAU - Shi, Jia-Wei
AU  - Shi JW
AD  - Zhejiang Pharmaceutical College, Ningbo, 315104, China.
FAU - Zhou, Jing-Feng
AU  - Zhou JF
AD  - Zhejiang Pharmaceutical College, Ningbo, 315104, China.
FAU - He, Xiong
AU  - He X
AD  - Zhejiang Pharmaceutical College, Ningbo, 315104, China.
FAU - Zhang, Yun
AU  - Zhang Y
AD  - Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Chromatogr Sci
JT  - Journal of chromatographic science
JID - 0173225
RN  - 0 (Amphetamines)
SB  - IM
MH  - Amphetamines/chemistry/isolation & purification/*urine
MH  - Equipment Design
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Humans
MH  - Limit of Detection
MH  - Linear Models
MH  - Reproducibility of Results
MH  - Solid Phase Extraction/instrumentation/*methods
MH  - Tandem Mass Spectrometry/*methods
EDAT- 2020/05/12 06:00
MHDA- 2021/04/01 06:00
CRDT- 2020/05/12 06:00
PHST- 2019/02/26 00:00 [received]
PHST- 2020/01/02 00:00 [revised]
PHST- 2020/05/12 06:00 [pubmed]
PHST- 2021/04/01 06:00 [medline]
PHST- 2020/05/12 06:00 [entrez]
AID - 5835493 [pii]
AID - 10.1093/chromsci/bmaa018 [doi]
PST - ppublish
SO  - J Chromatogr Sci. 2020 Jun 5;58(6):569-575. doi: 10.1093/chromsci/bmaa018.