PMID- 32390844
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 11
DP  - 2020
TI  - Quercetin Combined With Human Umbilical Cord Mesenchymal Stem Cells Regulated 
      Tumour Necrosis Factor-alpha/Interferon-gamma-Stimulated Peripheral Blood Mononuclear 
      Cells via Activation of Toll-Like Receptor 3 Signalling.
PG  - 499
LID - 10.3389/fphar.2020.00499 [doi]
LID - 499
AB  - The beneficial effect of quercetin in rheumatic diseases is unclear. Studies have 
      already confirmed that human umbilical cord mesenchymal stem cells (hUCMSCs) 
      alleviate some symptoms of rheumatoid arthritis (RA) by their immunosuppressive 
      capacities. This study explored whether there are additive effects of quercetin 
      and hUCMSCs on peripheral blood mononuclear cells (PBMCs) under simulated 
      rheumatic conditions. hUCMSCs were pretreated with quercetin (10 muM) before 
      coculture with TNF-alpha/IFN-gamma-stimulated PBMCs at a ratio of 1:1 for 3 days. PBMC 
      proliferation was inhibited, and the proportion of Th17 cells was shifted. These 
      effects may be related to the effect of quercetin on functional molecules in 
      hUCMSCs, including nitric oxide (NO), indoleamine 2,3-dioxygenase (IDO), 
      interleukin 6 (IL-6) and Toll-like receptor-3 (TLR-3) and the Akt/IkappaB pathways. 
      These results suggest that quercetin effectively promoted the immunoregulatory 
      effect of hUCMSCs by inhibiting the Akt/IkappaB pathway, activating the Toll-like 
      receptor-3 pathway, and regulating downstream cytokines.
CI  - Copyright (c) 2020 Chen, Ye, Cheng, Tao, Zhang, Huang, Deng, Yao, Lu and Huang.
FAU - Chen, Guiling
AU  - Chen G
AD  - Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 
      China.
AD  - Department of National Institute of Stem Cell Clinical Research, Guangdong 
      Provincial Hospital of Chinese Medicine, Guangzhou, China.
AD  - Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
FAU - Ye, Yang
AU  - Ye Y
AD  - Department of Shanghai Zhangjiang Biobank, National Engineering Centre for 
      Biochip at Shanghai, Shanghai, China.
FAU - Cheng, Ming
AU  - Cheng M
AD  - Department of Shanghai Zhangjiang Biobank, National Engineering Centre for 
      Biochip at Shanghai, Shanghai, China.
FAU - Tao, Yi
AU  - Tao Y
AD  - Department of Shanghai Zhangjiang Biobank, National Engineering Centre for 
      Biochip at Shanghai, Shanghai, China.
FAU - Zhang, Kejun
AU  - Zhang K
AD  - Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 
      China.
AD  - Department of National Institute of Stem Cell Clinical Research, Guangdong 
      Provincial Hospital of Chinese Medicine, Guangzhou, China.
AD  - Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
FAU - Huang, Qiong
AU  - Huang Q
AD  - Department of Shanghai Zhangjiang Biobank, National Engineering Centre for 
      Biochip at Shanghai, Shanghai, China.
FAU - Deng, Jingwen
AU  - Deng J
AD  - Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 
      China.
AD  - Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
AD  - Department of Dermatology, Guangdong Provincial Hospital of Chinese Medicine, 
      Guangzhou, China.
FAU - Yao, Danni
AU  - Yao D
AD  - Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 
      China.
AD  - Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
AD  - Department of Dermatology, Guangdong Provincial Hospital of Chinese Medicine, 
      Guangzhou, China.
FAU - Lu, Chuanjian
AU  - Lu C
AD  - Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 
      China.
AD  - Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
AD  - Department of Dermatology, Guangdong Provincial Hospital of Chinese Medicine, 
      Guangzhou, China.
FAU - Huang, Yu
AU  - Huang Y
AD  - Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 
      China.
AD  - Department of National Institute of Stem Cell Clinical Research, Guangdong 
      Provincial Hospital of Chinese Medicine, Guangzhou, China.
AD  - Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20200424
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC7194129
OTO - NOTNLM
OT  - Toll-like receptor 3
OT  - human umbilical cord mesenchymal stem cell
OT  - indoleamine 2,3-dioxygenase
OT  - interleukin 6
OT  - quercetin
OT  - rheumatoid arthritis
EDAT- 2020/05/12 06:00
MHDA- 2020/05/12 06:01
PMCR- 2020/04/24
CRDT- 2020/05/12 06:00
PHST- 2019/11/16 00:00 [received]
PHST- 2020/03/30 00:00 [accepted]
PHST- 2020/05/12 06:00 [entrez]
PHST- 2020/05/12 06:00 [pubmed]
PHST- 2020/05/12 06:01 [medline]
PHST- 2020/04/24 00:00 [pmc-release]
AID - 10.3389/fphar.2020.00499 [doi]
PST - epublish
SO  - Front Pharmacol. 2020 Apr 24;11:499. doi: 10.3389/fphar.2020.00499. eCollection 
      2020.