PMID- 32390968
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1664-302X (Print)
IS  - 1664-302X (Electronic)
IS  - 1664-302X (Linking)
VI  - 11
DP  - 2020
TI  - Genetic Diversity of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) 
      From 1996 to 2017 in China.
PG  - 618
LID - 10.3389/fmicb.2020.00618 [doi]
LID - 618
AB  - Porcine reproductive and respiratory syndrome (PRRS) is one of the most 
      devastating diseases of the global swine industry. The causative agent porcine 
      reproductive and respiratory syndrome virus (PRRSV) was first isolated in China 
      in 1996 and has evolved quickly during the last two decades. To fully understand 
      virus diversity, epidemic situation in the field, and make future predictions, a 
      total of 365 PRRSV strains were used for evolution and genome analysis in which 
      353 strains were isolated from mainland China. The results showed that high 
      diversity was found among PRRSV isolates. Total PRRSV isolates could be divided 
      into eight subgroups. Among these subgroups strains, Original HP-PRRSV, 
      NADC30-like, and Intermediate PRRSV were the major epidemic PRRSV strains 
      circling in the field and would play a major role in PRRS epidemic in the future. 
      Deletions, insertions, and recombinations have occurred frequently in the PRRSV 
      genome. Deletions were the main driving force of viral evolution before 2006 and 
      may also contribute further to the virus' evolution in a relatively closed or low 
      strain diversity circumstance. The recombinant strains could be divided into 
      three groups: the Inner group, Extensional group, and Propagating group. The 
      evolutionary directions of the isolates in the Extensional and Propagating groups 
      have changed, and the routes of recombination in the Propagating group were 
      analyzed and sorted into three types. The increases in recombinant strains and 
      high rates of recombination in recent years indicate that recombination has 
      played a very important role in the virus' evolution. Isolates, which incorporate 
      the advantages of their parental strains, will influence PRRSV evolution and make 
      adverse effects on PRRS control in the future.
CI  - Copyright (c) 2020 Jiang, Li, Yu, Li, Zhang, Zhou, Tong, Liu, Gao and Tong.
FAU - Jiang, Yifeng
AU  - Jiang Y
AD  - Research Team on Porcine Viral Reproductive Disorder Syndrome, Shanghai 
      Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 
      Shanghai, China.
FAU - Li, Guoxin
AU  - Li G
AD  - Research Team on Porcine Viral Reproductive Disorder Syndrome, Shanghai 
      Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 
      Shanghai, China.
FAU - Yu, Lingxue
AU  - Yu L
AD  - Research Team on Porcine Viral Reproductive Disorder Syndrome, Shanghai 
      Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 
      Shanghai, China.
FAU - Li, Liwei
AU  - Li L
AD  - Research Team on Porcine Viral Reproductive Disorder Syndrome, Shanghai 
      Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 
      Shanghai, China.
FAU - Zhang, Yujiao
AU  - Zhang Y
AD  - Research Team on Porcine Viral Reproductive Disorder Syndrome, Shanghai 
      Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 
      Shanghai, China.
FAU - Zhou, Yanjun
AU  - Zhou Y
AD  - Research Team on Porcine Viral Reproductive Disorder Syndrome, Shanghai 
      Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 
      Shanghai, China.
FAU - Tong, Wu
AU  - Tong W
AD  - Research Team on Porcine Viral Reproductive Disorder Syndrome, Shanghai 
      Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 
      Shanghai, China.
FAU - Liu, Changlong
AU  - Liu C
AD  - Research Team on Porcine Viral Reproductive Disorder Syndrome, Shanghai 
      Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 
      Shanghai, China.
FAU - Gao, Fei
AU  - Gao F
AD  - Research Team on Porcine Viral Reproductive Disorder Syndrome, Shanghai 
      Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 
      Shanghai, China.
FAU - Tong, Guangzhi
AU  - Tong G
AD  - Research Team on Porcine Viral Reproductive Disorder Syndrome, Shanghai 
      Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 
      Shanghai, China.
AD  - Jiangsu Co-innovation Center for the Prevention and Control of Important Animal 
      Infectious Disease and Zoonosis, Yangzhou University, Yangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20200424
PL  - Switzerland
TA  - Front Microbiol
JT  - Frontiers in microbiology
JID - 101548977
PMC - PMC7193098
OTO - NOTNLM
OT  - evolution
OT  - genetic diversity
OT  - phylogenetic trees
OT  - porcine reproductive and respiratory syndrome virus (PRRSV)
OT  - recombination
EDAT- 2020/05/12 06:00
MHDA- 2020/05/12 06:01
PMCR- 2020/04/24
CRDT- 2020/05/12 06:00
PHST- 2020/01/09 00:00 [received]
PHST- 2020/03/19 00:00 [accepted]
PHST- 2020/05/12 06:00 [entrez]
PHST- 2020/05/12 06:00 [pubmed]
PHST- 2020/05/12 06:01 [medline]
PHST- 2020/04/24 00:00 [pmc-release]
AID - 10.3389/fmicb.2020.00618 [doi]
PST - epublish
SO  - Front Microbiol. 2020 Apr 24;11:618. doi: 10.3389/fmicb.2020.00618. eCollection 
      2020.