PMID- 32392207
OWN - NLM
STAT- MEDLINE
DCOM- 20200728
LR  - 20200728
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 15
IP  - 5
DP  - 2020
TI  - The qualitative assessment of optical coherence tomography and the central 
      retinal sensitivity in patients with retinitis pigmentosa.
PG  - e0232700
LID - 10.1371/journal.pone.0232700 [doi]
LID - e0232700
AB  - PURPOSE: To analyze the relationships between qualitative and quantitative 
      parameters of spectral-domain optical coherence tomography (SD-OCT) and the 
      central retinal sensitivity in patients with retinitis pigmentosa (RP). MATERIALS 
      AND METHODS: Ninety-three eyes of 93 patients were finally enrolled, with a 
      median age (quartile) of 58 (24.5) years. We assessed the patients using SD-OCT 
      and the 10-2 program of a Humphry Field Analyzer (HFA). As a qualitative 
      parameter, two graders independently classified the patients' SD-OCT images into 
      five severity grades (grades 1-5) based on the severity of damage to the 
      photoreceptor inner and outer segments (IS/OS) layer. As quantitative parameters, 
      we measured the IS-ellipsoid zone (IS-EZ) width, IS/OS thickness, outer nuclear 
      layer (ONL) thickness, central macular thickness (CMT, 1 and 3 mm) and macular 
      cube (6 x 6 mm) volume and thickness. The central retinal sensitivity was defined 
      by the best-corrected visual acuity (BCVA; logMAR), average sensitivities of the 
      central 4 (foveal sensitivity [FS]) and 12 (macular sensitivity [MS]) points of 
      the HFA 10-2 program and the mean deviation (MD) of the 10-2 program. Spearman's 
      correlation was used to assess the association between both qualitative and 
      quantitative parameters and variables of the central retinal sensitivity. In 
      addition, we performed a multiple regression analysis using these parameters to 
      identify the parameters most strongly influencing the central retinal 
      sensitivity. RESULTS: The IS/OS severity grade was significantly correlated with 
      the BCVA (rho = 0.741, P < 0.001), FS (rho = -0.844, P < 0.001), MS (rho = -0.820, P < 
      0.001) and MD (rho = -0.681, P < 0.001) and showed stronger correlations to them 
      than any other quantitative parameters including the IS-EZ width, IS/OS 
      thickness, ONL thickness, CMTs and macular cube volume/thickness. Furthermore, a 
      step-wise multiple regression analysis indicated that the IS/OS severity grade 
      was more strongly associated with the BCVA (beta = 0.659, P < 0.001), FS (beta = 
      -0.820, P < 0.001), MS (beta = -0.820, P < 0.001) and MD (beta = -0.674, P < 0.001) 
      than any other quantitative parameters. The intraclass correlation coefficient 
      between two graders indicated substantial correlation (kappa = 0.70). DISCUSSION: The 
      qualitative grading of OCT based on the severity of the IS/OS layer was simple 
      and strongly correlated with the central retinal sensitivity in patients with RP. 
      It may be useful to assess the central visual function in patients with RP, 
      although there is some variation in severity within the same severity grade.
FAU - Hara, Aiko
AU  - Hara A
AD  - Department of Ophthalmology, Hirosaki University Graduate School of Medicine, 
      Hirosaki, Japan.
FAU - Nakazawa, Mitsuru
AU  - Nakazawa M
AUID- ORCID: 0000-0001-6095-5712
AD  - Department of Ophthalmology, Hirosaki University Graduate School of Medicine, 
      Hirosaki, Japan.
FAU - Saito, Masaaki
AU  - Saito M
AD  - Department of Ophthalmology, Hirosaki University Graduate School of Medicine, 
      Hirosaki, Japan.
FAU - Suzuki, Yukihiko
AU  - Suzuki Y
AD  - Department of Ophthalmology, Hirosaki University Graduate School of Medicine, 
      Hirosaki, Japan.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20200511
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Female
MH  - Fundus Oculi
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
MH  - Retina/*diagnostic imaging/pathology/*physiopathology
MH  - Retinitis Pigmentosa/*diagnostic imaging/*physiopathology
MH  - *Tomography, Optical Coherence
MH  - Young Adult
PMC - PMC7213731
COIS- Mitsuru Nakazawa received research funds from Alcon (Tokyo, Japan), Novartis 
      (Tokyo, Japan), Santen (Osaka, Japan), AMO (Tokyo, Japan), HOYA (Tokyo, Japan) 
      and Pfizer (Tokyo, Japan). The funders had no role in study design, data 
      collection and analysis, decision to publish or preparation of the manuscript. 
      This does not alter our adherence to PLOS ONE policies on sharing data and 
      materials.
EDAT- 2020/05/12 06:00
MHDA- 2020/07/29 06:00
PMCR- 2020/05/11
CRDT- 2020/05/12 06:00
PHST- 2020/02/09 00:00 [received]
PHST- 2020/04/19 00:00 [accepted]
PHST- 2020/05/12 06:00 [entrez]
PHST- 2020/05/12 06:00 [pubmed]
PHST- 2020/07/29 06:00 [medline]
PHST- 2020/05/11 00:00 [pmc-release]
AID - PONE-D-20-03802 [pii]
AID - 10.1371/journal.pone.0232700 [doi]
PST - epublish
SO  - PLoS One. 2020 May 11;15(5):e0232700. doi: 10.1371/journal.pone.0232700. 
      eCollection 2020.